ENSG00000285967

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000647750 ENSG00000285967 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL-DT lncRNA lncRNA 3.229226 3.30993 3.505369 0.5625611 0.092796 0.08252309 0.2833440 0.1685408 0.4136145 0.04395619 0.05639401 1.246498 0.08738333 0.05486667 0.1173333 0.06246667 4.081160e-01 1.503451e-09 TRUE FALSE
ENST00000647824 ENSG00000285967 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL-DT lncRNA lncRNA 3.229226 3.30993 3.505369 0.5625611 0.092796 0.08252309 0.4263384 1.1813821 0.0000000 0.28435345 0.00000000 -6.896492 0.16561667 0.36760000 0.0000000 -0.36760000 5.881959e-07 1.503451e-09 TRUE FALSE
ENST00000649921 ENSG00000285967 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL-DT lncRNA lncRNA 3.229226 3.30993 3.505369 0.5625611 0.092796 0.08252309 1.7566206 0.8712483 3.0917543 0.05268991 0.03952735 1.815464 0.52943750 0.28170000 0.8826667 0.60096667 1.503451e-09 1.503451e-09 FALSE FALSE
MSTRG.26080.6 ENSG00000285967 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL-DT lncRNA   3.229226 3.30993 3.505369 0.5625611 0.092796 0.08252309 0.7039018 1.0887591 0.0000000 0.63734761 0.00000000 -6.779731 0.19818750 0.29576667 0.0000000 -0.29576667 2.976413e-01 1.503451e-09 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000285967 E001 9.682082 0.961751701 3.041600e-01 5.447518e-01 5 36864425 36865843 1419 - 1.175 0.812 -1.345
ENSG00000285967 E002 2.122861 0.949852730 3.071536e-01 5.477678e-01 5 36865844 36866026 183 - 0.620 0.306 -1.630
ENSG00000285967 E003 33.978407 0.024362864 3.958484e-01 6.250678e-01 5 36871364 36871918 555 - 1.638 1.451 -0.639
ENSG00000285967 E004 38.449930 0.001232647 3.451350e-01 5.827039e-01 5 36871919 36872642 724 - 1.684 1.527 -0.536
ENSG00000285967 E005 95.908149 0.174636200 6.657918e-01 8.135353e-01 5 36872643 36875670 3028 - 2.107 1.820 -0.965
ENSG00000285967 E006 14.810509 0.011138656 2.554063e-01 4.940417e-01 5 36875671 36875791 121 - 1.306 1.084 -0.786
ENSG00000285967 E007 12.498952 0.003144314 4.598394e-02 1.700076e-01 5 36875792 36875843 52 - 1.095 1.178 0.297
ENSG00000285967 E008 37.658590 0.001402393 5.871235e-07 1.786865e-05 5 36875844 36876158 315 - 1.507 1.672 0.563
ENSG00000285967 E009 52.390136 0.006412916 6.943492e-08 2.678094e-06 5 36876159 36876700 542 - 1.627 1.821 0.656