ENSG00000285533

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000648185 ENSG00000285533 HEK293_OSMI2_6hA HEK293_TMG_6hB RELA-DT lncRNA lncRNA 4.392081 6.93361 1.516595 1.092617 0.1520908 -2.185369 0.1603108 0.1097093 0.183935 0.1097093 0.1305458 0.6960387 0.05060000 0.02263333 0.1301 0.10746667 0.59910486 0.04429819 TRUE FALSE
ENST00000690937 ENSG00000285533 HEK293_OSMI2_6hA HEK293_TMG_6hB RELA-DT lncRNA lncRNA 4.392081 6.93361 1.516595 1.092617 0.1520908 -2.185369 0.2095450 0.8752331 0.000000 0.7030097 0.0000000 -6.4679856 0.04009167 0.10463333 0.0000 -0.10463333 0.63465568 0.04429819 TRUE FALSE
ENST00000691526 ENSG00000285533 HEK293_OSMI2_6hA HEK293_TMG_6hB RELA-DT lncRNA lncRNA 4.392081 6.93361 1.516595 1.092617 0.1520908 -2.185369 0.3872538 0.8058595 0.000000 0.4244870 0.0000000 -6.3502489 0.07707083 0.10360000 0.0000 -0.10360000 0.04429819 0.04429819   FALSE
MSTRG.5732.4 ENSG00000285533 HEK293_OSMI2_6hA HEK293_TMG_6hB RELA-DT lncRNA   4.392081 6.93361 1.516595 1.092617 0.1520908 -2.185369 2.8969163 4.1616726 1.119241 0.2854223 0.2789379 -1.8852724 0.66478333 0.62696667 0.7204 0.09343333 0.85401752 0.04429819   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000285533 E001 0.6783511 0.019387492 0.792908169   11 65663001 65663002 2 + 0.000 0.175 8.845
ENSG00000285533 E002 0.6783511 0.019387492 0.792908169   11 65663003 65663005 3 + 0.000 0.175 9.850
ENSG00000285533 E003 0.6783511 0.019387492 0.792908169   11 65663006 65663006 1 + 0.000 0.175 9.850
ENSG00000285533 E004 10.7115810 0.004188243 0.015613043 0.08040561 11 65663007 65663067 61 + 0.546 0.951 1.660
ENSG00000285533 E005 10.3779786 0.005752068 0.020084572 0.09617703 11 65663068 65663071 4 + 0.546 0.939 1.614
ENSG00000285533 E006 10.3779786 0.005752068 0.020084572 0.09617703 11 65663072 65663077 6 + 0.546 0.939 1.614
ENSG00000285533 E007 15.4041526 0.004432945 0.125633151 0.32485965 11 65663078 65663126 49 + 0.887 1.080 0.718
ENSG00000285533 E008 13.8278405 0.003480138 0.418391795 0.64240957 11 65663127 65663148 22 + 0.931 1.028 0.359
ENSG00000285533 E009 2.3620213 0.009641114 0.981220390 0.99238171 11 65663149 65663268 120 + 0.427 0.417 -0.055
ENSG00000285533 E010 6.0960666 0.005913892 0.332459898 0.57122530 11 65663269 65663426 158 + 0.546 0.718 0.750
ENSG00000285533 E011 14.8176763 0.035704982 0.861779551 0.93128170 11 65663427 65663683 257 + 1.009 1.034 0.092
ENSG00000285533 E012 9.7321502 0.066769765 0.003931489 0.02876221 11 65663684 65665420 1737 + 1.233 0.782 -1.669
ENSG00000285533 E013 28.3736581 0.001477235 0.107120949 0.29420062 11 65665421 65665543 123 + 1.417 1.279 -0.480
ENSG00000285533 E014 23.3203017 0.006208462 0.271245314 0.51122047 11 65666131 65666217 87 + 1.307 1.194 -0.398
ENSG00000285533 E015 5.2808054 0.005193531 0.201337404 0.43137899 11 65666218 65667304 1087 + 0.427 0.675 1.155
ENSG00000285533 E016 28.9226687 0.002239043 0.069682454 0.22414826 11 65671423 65671718 296 + 1.431 1.277 -0.535