ENSG00000281706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000628328 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.8970167 0.83473588 1.1601228 0.22754578 0.2609579 0.4700877 0.19740000 0.20560000 0.21856667 0.01296667 0.97913900 0.04329861   FALSE
ENST00000662411 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.3192312 0.07059046 0.5186293 0.07059046 0.2833212 2.7135754 0.06354583 0.01553333 0.09483333 0.07930000 0.69097054 0.04329861   FALSE
ENST00000686567 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.1063980 0.00000000 0.3031732 0.00000000 0.1593020 4.9688890 0.02386250 0.00000000 0.05803333 0.05803333 0.34973342 0.04329861 FALSE FALSE
ENST00000687535 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.2645183 0.38588158 0.0000000 0.27680006 0.0000000 -5.3069970 0.06186667 0.09893333 0.00000000 -0.09893333 0.04329861 0.04329861 FALSE FALSE
ENST00000687781 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.4221882 0.51710072 0.1136932 0.34292987 0.1136932 -2.0913129 0.10547500 0.14013333 0.02726667 -0.11286667 0.70513347 0.04329861   FALSE
ENST00000689802 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.8681974 1.01319841 0.6830956 0.13080223 0.1346832 -0.5619596 0.20939167 0.25020000 0.12950000 -0.12070000 0.05924395 0.04329861   FALSE
ENST00000693575 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA lncRNA 4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.5478463 0.40199774 1.0056732 0.21170937 0.1254453 1.3017279 0.12477083 0.09743333 0.20470000 0.10726667 0.70947636 0.04329861   FALSE
MSTRG.27860.14 ENSG00000281706 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01012 lncRNA   4.388195 4.016887 5.185385 0.2727695 0.6270872 0.3675658 0.3519912 0.22245678 0.8571248 0.12004594 0.2407654 1.8992772 0.07785417 0.05220000 0.16210000 0.10990000 0.39931792 0.04329861   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000281706 E001 0.7616940 0.044046429 0.207455982   6 27694027 27694034 8 + 0.350 0.126 -1.886
ENSG00000281706 E002 1.1064427 0.274517294 0.774538448   6 27694035 27694038 4 + 0.346 0.306 -0.255
ENSG00000281706 E003 1.2490774 0.356160266 0.651505199   6 27694039 27694042 4 + 0.399 0.306 -0.557
ENSG00000281706 E004 1.3917120 0.448120149 0.587238241 0.76178109 6 27694043 27694044 2 + 0.446 0.307 -0.801
ENSG00000281706 E005 1.3917120 0.448120149 0.587238241 0.76178109 6 27694045 27694045 1 + 0.446 0.307 -0.801
ENSG00000281706 E006 1.8148640 0.082579872 0.706399788 0.83958855 6 27694046 27694052 7 + 0.499 0.426 -0.369
ENSG00000281706 E007 2.6250787 0.146344345 0.664457858 0.81268889 6 27694053 27694057 5 + 0.608 0.524 -0.383
ENSG00000281706 E008 2.7559469 0.120977978 0.808700887 0.90141518 6 27694058 27694059 2 + 0.608 0.563 -0.203
ENSG00000281706 E009 4.1268887 0.007123133 0.829389728 0.91346066 6 27694060 27694067 8 + 0.728 0.700 -0.115
ENSG00000281706 E010 4.2992631 0.007816135 0.984956657 0.99430447 6 27694068 27694072 5 + 0.728 0.729 0.001
ENSG00000281706 E011 7.1560128 0.010129638 0.293950770 0.53459703 6 27694073 27694078 6 + 0.858 0.986 0.482
ENSG00000281706 E012 8.6485227 0.005996809 0.159202498 0.37556080 6 27694079 27694084 6 + 0.911 1.068 0.584
ENSG00000281706 E013 29.2763809 0.004584602 0.022307202 0.10362553 6 27694085 27694226 142 + 1.401 1.555 0.526
ENSG00000281706 E014 34.3158174 0.001731591 0.005838874 0.03894180 6 27694227 27694506 280 + 1.620 1.464 -0.534
ENSG00000281706 E015 0.6494192 0.021186744 0.351440348   6 27694507 27695137 631 + 0.286 0.126 -1.475
ENSG00000281706 E016 3.9131256 0.009674044 0.523372268 0.71736952 6 27699597 27699667 71 + 0.729 0.638 -0.379
ENSG00000281706 E017 30.3745119 0.001263636 0.006285819 0.04113114 6 27702314 27702417 104 + 1.408 1.578 0.583
ENSG00000281706 E018 1.5798331 0.229405656 0.671514260 0.81725814 6 27702418 27702713 296 + 0.350 0.440 0.501
ENSG00000281706 E019 2.5272089 0.009354221 0.271498824 0.51137716 6 27706639 27707338 700 + 0.457 0.638 0.840
ENSG00000281706 E020 1.7666826 0.011144763 0.023802772 0.10849952 6 27707339 27707416 78 + 0.210 0.603 2.275
ENSG00000281706 E021 5.3288528 0.005040030 0.506077650 0.70500492 6 27707417 27709157 1741 + 0.839 0.755 -0.334
ENSG00000281706 E022 20.6881559 0.010282947 0.555313580 0.73998328 6 27710124 27710225 102 + 1.314 1.373 0.205
ENSG00000281706 E023 41.8964593 0.025654283 0.471488754 0.68120021 6 27710681 27710853 173 + 1.597 1.661 0.219
ENSG00000281706 E024 25.0791598 0.020017376 0.177557849 0.40052204 6 27710854 27710889 36 + 1.341 1.470 0.447
ENSG00000281706 E025 16.7444824 0.031284508 0.353905661 0.59075185 6 27710890 27711089 200 + 1.282 1.194 -0.308
ENSG00000281706 E026 17.8416544 0.004233321 0.151424423 0.36440922 6 27711090 27711230 141 + 1.327 1.214 -0.396
ENSG00000281706 E027 4.4862076 0.030302405 0.019447550 0.09400396 6 27711231 27711354 124 + 0.893 0.523 -1.546
ENSG00000281706 E028 57.7373010 0.001228162 0.021030857 0.09944378 6 27713004 27713706 703 + 1.813 1.715 -0.332