ENSG00000281649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000625218 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 1.02912855 0.1201090 3.000716 0.12010904 0.73555983 4.5323133 0.083395833 0.02413333 0.15016667 0.126033333 0.210813293 0.003185331   FALSE
ENST00000625445 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 1.72451906 1.3399686 2.607420 0.28081307 0.07506388 0.9552193 0.212333333 0.32443333 0.13076667 -0.193666667 0.003185331 0.003185331   FALSE
ENST00000627197 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 1.16668681 0.8469282 2.957599 0.61792147 0.10274599 1.7920499 0.089383333 0.20390000 0.14826667 -0.055633333 0.939550028 0.003185331 FALSE FALSE
ENST00000628924 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 0.78087925 0.2439523 1.548369 0.02527811 0.13017221 2.6174070 0.064541667 0.06350000 0.07746667 0.013966667 0.847391332 0.003185331   FALSE
ENST00000631093 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 1.54013819 0.5326060 2.174538 0.53260598 0.37342666 2.0093517 0.133383333 0.10703333 0.10816667 0.001133333 0.609844090 0.003185331 FALSE FALSE
ENST00000657640 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 0.02707503 0.2166002 0.000000 0.21660022 0.00000000 -4.5020774 0.008470833 0.06776667 0.00000000 -0.067766667 0.711736325 0.003185331   FALSE
ENST00000664382 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA lncRNA 11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 0.35427815 0.0000000 0.000000 0.00000000 0.00000000 0.0000000 0.097116667 0.00000000 0.00000000 0.000000000   0.003185331   FALSE
MSTRG.32657.2 ENSG00000281649 HEK293_OSMI2_6hA HEK293_TMG_6hB EBLN3P lncRNA   11.40302 4.0562 19.95875 0.5147826 0.5015147 2.295991 2.72084169 0.1739645 4.398162 0.17396453 0.25443870 4.5826777 0.157758333 0.03496667 0.22023333 0.185266667 0.157583787 0.003185331   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000281649 E001 0.0000000       9 37079645 37079744 100 +      
ENSG00000281649 E002 0.0000000       9 37079840 37079851 12 +      
ENSG00000281649 E003 0.0000000       9 37079852 37079852 1 +      
ENSG00000281649 E004 0.0000000       9 37079853 37079853 1 +      
ENSG00000281649 E005 0.0000000       9 37079854 37079856 3 +      
ENSG00000281649 E006 0.0000000       9 37079857 37079858 2 +      
ENSG00000281649 E007 0.1614157 0.0324907325 1.000000e+00   9 37079859 37079873 15 + 0.066 0.000 -7.946
ENSG00000281649 E008 0.1614157 0.0324907325 1.000000e+00   9 37079874 37079879 6 + 0.066 0.000 -9.240
ENSG00000281649 E009 1.2928691 0.0136968632 5.691347e-01   9 37079880 37079905 26 + 0.330 0.215 -0.834
ENSG00000281649 E010 1.2928691 0.0136968632 5.691347e-01   9 37079906 37079907 2 + 0.330 0.215 -0.834
ENSG00000281649 E011 1.8821887 0.0383496736 2.824800e-01 5.228889e-01 9 37079908 37079913 6 + 0.445 0.215 -1.477
ENSG00000281649 E012 1.8821887 0.0383496736 2.824800e-01 5.228889e-01 9 37079914 37079916 3 + 0.445 0.215 -1.477
ENSG00000281649 E013 2.6682732 0.0263082223 1.063391e-01 2.928944e-01 9 37079917 37079928 12 + 0.556 0.215 -2.020
ENSG00000281649 E014 5.6966956 0.0054543712 1.445221e-01 3.541941e-01 9 37079929 37079934 6 + 0.793 0.551 -1.027
ENSG00000281649 E015 5.6966956 0.0054543712 1.445221e-01 3.541941e-01 9 37079935 37079936 2 + 0.793 0.551 -1.027
ENSG00000281649 E016 10.5930010 0.0062345733 4.219275e-01 6.451104e-01 9 37079937 37079956 20 + 1.005 0.904 -0.377
ENSG00000281649 E017 29.8601470 0.0017768562 2.140885e-01 4.464660e-01 9 37079957 37080030 74 + 1.427 1.331 -0.334
ENSG00000281649 E018 19.7491802 0.0023081368 2.859703e-01 5.266306e-01 9 37080031 37080034 4 + 1.258 1.158 -0.352
ENSG00000281649 E019 16.8766318 0.0022525535 9.031648e-02 2.643440e-01 9 37080035 37080038 4 + 1.204 1.024 -0.646
ENSG00000281649 E020 43.3058410 0.0009651422 8.911768e-01 9.472472e-01 9 37080039 37080341 303 + 1.563 1.557 -0.018
ENSG00000281649 E021 17.7746567 0.0296460432 9.709768e-01 9.873372e-01 9 37080342 37080357 16 + 1.188 1.192 0.014
ENSG00000281649 E022 60.2707250 0.0011401930 6.105955e-01 7.773416e-01 9 37080358 37080536 179 + 1.703 1.677 -0.085
ENSG00000281649 E023 5.3877894 0.0093869114 2.311403e-02 1.063131e-01 9 37080537 37080858 322 + 0.782 0.358 -1.984
ENSG00000281649 E024 12.9916819 0.0099226377 6.431967e-03 4.183439e-02 9 37080859 37081594 736 + 1.120 0.739 -1.443
ENSG00000281649 E025 2.8310939 0.0797235386 7.752165e-01 8.818735e-01 9 37081595 37081865 271 + 0.535 0.466 -0.337
ENSG00000281649 E026 34.5730736 0.0624734806 8.088880e-01 9.015232e-01 9 37081866 37084198 2333 + 1.466 1.451 -0.052
ENSG00000281649 E027 6.4082775 0.1572785797 4.441182e-01 6.614866e-01 9 37084199 37084292 94 + 0.737 0.944 0.806
ENSG00000281649 E028 38.0108912 0.0013899870 1.662570e-01 3.855718e-01 9 37084990 37086667 1678 + 1.522 1.424 -0.336
ENSG00000281649 E029 935.5813798 0.0002470231 6.882781e-01 8.279898e-01 9 37086668 37089800 3133 + 2.880 2.886 0.019
ENSG00000281649 E030 66.6585022 0.0026506985 1.792301e-08 7.950225e-07 9 37089801 37090928 1128 + 1.661 1.950 0.974
ENSG00000281649 E031 0.2852693 0.2499533249 1.000000e+00   9 37123185 37123227 43 + 0.121 0.000 -9.686