ENSG00000281357

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000625713 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA lncRNA 2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.1323449 0.09351337 0.2010437 0.05086290 0.02989231 1.0277247 0.05306667 0.04513333 0.08250000 0.03736667 0.72804835 0.04152335 TRUE  
ENST00000629389 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA lncRNA 2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.8412903 0.49630006 0.3654584 0.29136533 0.27265912 -0.4313394 0.32232917 0.24796667 0.16150000 -0.08646667 0.92602849 0.04152335    
ENST00000630823 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA lncRNA 2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.2281283 0.52170996 0.0000000 0.52170996 0.00000000 -5.7325676 0.09042917 0.29373333 0.00000000 -0.29373333 0.91173035 0.04152335    
ENST00000661720 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA lncRNA 2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.1247447 0.07257494 0.2519028 0.05388740 0.08227544 1.6652558 0.05067083 0.04523333 0.09876667 0.05353333 0.64896094 0.04152335    
ENST00000690875 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA lncRNA 2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.1879196 0.02318757 0.2639684 0.01213965 0.06775001 3.0452945 0.07064583 0.01376667 0.10573333 0.09196667 0.04152335 0.04152335    
MSTRG.26559.2 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA   2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.8743431 0.48207763 1.2903220 0.25745950 0.30365569 1.4019112 0.33537083 0.24763333 0.51290000 0.26526667 0.65929487 0.04152335    
MSTRG.26559.8 ENSG00000281357 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3-AS1 lncRNA   2.587622 1.882891 2.467367 0.217955 0.1892054 0.3882166 0.1076801 0.15981031 0.0000000 0.08213298 0.00000000 -4.0858522 0.04340000 0.08780000 0.00000000 -0.08780000 0.20223599 0.04152335 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000281357 E001 0.8569551 0.029646605 0.665550662   5 91380349 91380378 30 + 0.222 0.287 0.491
ENSG00000281357 E002 1.6007256 0.013240889 0.982874099 0.99321636 5 91380379 91380396 18 + 0.426 0.408 -0.098
ENSG00000281357 E003 1.7315937 0.015220452 0.788960829 0.88986598 5 91380397 91380405 9 + 0.426 0.458 0.163
ENSG00000281357 E004 9.6532241 0.003404118 0.164485058 0.38335226 5 91380406 91380514 109 + 0.970 1.087 0.427
ENSG00000281357 E005 10.1366863 0.003271189 0.834755885 0.91641239 5 91380515 91380581 67 + 1.055 1.052 -0.008
ENSG00000281357 E006 15.9376967 0.003460674 0.944686659 0.97468352 5 91380582 91380704 123 + 1.239 1.220 -0.067
ENSG00000281357 E007 14.0415150 0.013389603 0.038800305 0.15162887 5 91380705 91380849 145 + 1.090 1.257 0.596
ENSG00000281357 E008 10.2596777 0.005539351 0.001769463 0.01549545 5 91380850 91380924 75 + 0.884 1.177 1.073
ENSG00000281357 E009 7.6219561 0.012548909 0.407333676 0.63396056 5 91418709 91418771 63 + 0.903 0.974 0.266
ENSG00000281357 E010 1.3867724 0.012871535 0.324627832   5 91418772 91418854 83 + 0.301 0.458 0.903
ENSG00000281357 E011 11.7659991 0.085548371 0.008103721 0.04980577 5 91418855 91420370 1516 + 1.274 0.859 -1.517
ENSG00000281357 E012 5.0789463 0.048472291 0.706711320 0.83974725 5 91420371 91420715 345 + 0.824 0.752 -0.285
ENSG00000281357 E013 1.1848460 0.015515392 0.476424246   5 91422778 91422965 188 + 0.426 0.286 -0.835
ENSG00000281357 E014 0.5117739 0.024441170 0.564217979   5 91438940 91439085 146 + 0.222 0.118 -1.098
ENSG00000281357 E015 0.0000000       5 91470013 91470151 139 +      
ENSG00000281357 E016 2.7513353 0.008857116 0.025785828 0.11463651 5 91470838 91470887 50 + 0.727 0.352 -1.797
ENSG00000281357 E017 3.5429591 0.097818915 0.005796616 0.03872841 5 91470888 91471872 985 + 0.850 0.290 -2.677
ENSG00000281357 E018 0.8265952 0.017590584 0.664351533   5 91495264 91495497 234 + 0.222 0.287 0.489
ENSG00000281357 E019 0.6897577 0.098670426 0.327396446   5 91495498 91496988 1491 + 0.303 0.118 -1.689
ENSG00000281357 E020 0.6791589 0.020511314 0.999716586   5 91547915 91548799 885 + 0.222 0.211 -0.093
ENSG00000281357 E021 0.6316833 0.023801722 0.308253455   5 91596441 91596551 111 + 0.301 0.118 -1.686
ENSG00000281357 E022 1.1120522 0.030726734 0.262469964   5 91610697 91612566 1870 + 0.426 0.211 -1.414