ENSG00000276644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613252 ENSG00000276644 HEK293_OSMI2_6hA HEK293_TMG_6hB DACH1 protein_coding protein_coding 5.178289 3.156255 8.098637 0.971316 0.2302714 1.356682 4.3977592 3.03330973 6.5740860 0.95612315 0.2301200 1.113342 0.87908750 0.95063333 0.81220000 -0.138433333 0.051587168 0.008670064 FALSE TRUE
ENST00000619232 ENSG00000276644 HEK293_OSMI2_6hA HEK293_TMG_6hB DACH1 protein_coding protein_coding 5.178289 3.156255 8.098637 0.971316 0.2302714 1.356682 0.3743932 0.09312661 0.4281367 0.02904948 0.1351463 2.086965 0.06224583 0.04266667 0.05213333 0.009466667 0.935062021 0.008670064 FALSE TRUE
MSTRG.8862.5 ENSG00000276644 HEK293_OSMI2_6hA HEK293_TMG_6hB DACH1 protein_coding   5.178289 3.156255 8.098637 0.971316 0.2302714 1.356682 0.3706883 0.02981891 1.0748191 0.02981891 0.2653487 4.767857 0.05063750 0.00670000 0.13286667 0.126166667 0.008670064 0.008670064 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000276644 E001 247.021455 0.0070041740 0.004877764 0.03395967 13 71437966 71439945 1980 - 2.320 2.450 0.433
ENSG00000276644 E002 30.085964 0.0191747937 0.814893957 0.90518671 13 71439946 71440069 124 - 1.463 1.461 -0.008
ENSG00000276644 E003 107.053728 0.0114755198 0.064003113 0.21167720 13 71440070 71440692 623 - 2.031 1.942 -0.298
ENSG00000276644 E004 44.206864 0.0138605392 0.424559979 0.64696025 13 71475141 71475209 69 - 1.644 1.585 -0.201
ENSG00000276644 E005 78.524211 0.0006871972 0.464118052 0.67594714 13 71475706 71475849 144 - 1.879 1.868 -0.037
ENSG00000276644 E006 91.347005 0.0006508660 0.341565481 0.57943184 13 71479169 71479316 148 - 1.949 1.932 -0.057
ENSG00000276644 E007 72.732007 0.0005565317 0.172934126 0.39437861 13 71488997 71489148 152 - 1.856 1.816 -0.134
ENSG00000276644 E008 51.848549 0.0008723434 0.517982043 0.71360411 13 71557024 71557158 135 - 1.682 1.734 0.175
ENSG00000276644 E009 44.390895 0.0008384602 0.473521589 0.68245926 13 71559820 71559955 136 - 1.638 1.618 -0.070
ENSG00000276644 E010 49.468156 0.0007279251 0.174383080 0.39637076 13 71572840 71573012 173 - 1.694 1.642 -0.178
ENSG00000276644 E011 2.789156 0.0088060371 0.975562501 0.98958497 13 71573418 71573573 156 - 0.562 0.582 0.089
ENSG00000276644 E012 42.542349 0.0010502249 0.069324648 0.22341202 13 71630556 71630717 162 - 1.644 1.559 -0.290
ENSG00000276644 E013 43.641771 0.0129785189 0.681984185 0.82395971 13 71681795 71681910 116 - 1.616 1.654 0.129
ENSG00000276644 E014 65.074533 0.0173243677 0.573342644 0.75253521 13 71865922 71866425 504 - 1.781 1.824 0.145
ENSG00000276644 E015 4.107936 0.0700731662 0.215016460 0.44758878 13 71866426 71866549 124 - 0.612 0.820 0.857
ENSG00000276644 E016 50.145574 0.0009006076 0.571218257 0.75119253 13 71866550 71867326 777 - 1.688 1.677 -0.037