ENSG00000276550

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614571 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 2.8476283 3.0160080 3.9789890 1.1326595 0.3565732 0.3986073 0.17672917 0.13763333 0.23850000 0.10086667 0.29213208 0.02120836   FALSE
ENST00000615156 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 1.5686518 1.8927333 2.3985993 0.6671060 0.2711204 0.3401210 0.09380833 0.08463333 0.14323333 0.05860000 0.17230862 0.02120836 TRUE FALSE
ENST00000619021 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 0.5033143 1.2983477 0.2221560 0.7666557 0.2221560 -2.4945796 0.03515000 0.08113333 0.01383333 -0.06730000 0.68726006 0.02120836 TRUE TRUE
ENST00000690192 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 3.4166228 4.0620690 2.0892785 0.8259097 0.4355962 -0.9558685 0.21590000 0.20266667 0.12526667 -0.07740000 0.59603562 0.02120836 TRUE TRUE
MSTRG.10313.12 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 0.8902691 0.7822366 1.4096215 0.4032291 0.1865741 0.8415031 0.05020000 0.03180000 0.08410000 0.05230000 0.08132964 0.02120836 TRUE TRUE
MSTRG.10313.13 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 2.0503962 1.9659092 2.8046231 0.5549510 0.2239070 0.5104251 0.12666667 0.09193333 0.16856667 0.07663333 0.05301620 0.02120836 TRUE TRUE
MSTRG.10313.16 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 1.9873238 3.3593232 1.0464041 1.0584382 0.1213222 -1.6732970 0.12207917 0.15190000 0.06303333 -0.08886667 0.02307535 0.02120836 TRUE TRUE
MSTRG.10313.3 ENSG00000276550 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 21.76618 16.68969 6.49429 0.3164378 -0.382929 0.8541102 1.3014334 0.5966041 0.4130419 0.3049111 -1.1123175 0.05621667 0.05920000 0.03616667 -0.02303333 0.80765740 0.02120836 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000276550 E001 0.0000000       15 22494841 22494847 7 +      
ENSG00000276550 E002 0.0000000       15 22494848 22494855 8 +      
ENSG00000276550 E003 0.1426347 0.0344797744 2.744925e-01   15 22494856 22494863 8 + 0.161 0.000 -10.817
ENSG00000276550 E004 0.4873834 0.0299473334 1.000000e+00   15 22494864 22494870 7 + 0.161 0.166 0.050
ENSG00000276550 E005 0.8433510 0.0249934051 2.502813e-01   15 22494871 22494872 2 + 0.371 0.166 -1.539
ENSG00000276550 E006 1.2892282 0.0138381533 3.696589e-01   15 22494873 22494874 2 + 0.447 0.285 -0.954
ENSG00000276550 E007 5.6310881 0.0165903713 6.321766e-01 0.791789185 15 22494875 22494899 25 + 0.836 0.769 -0.262
ENSG00000276550 E008 10.2422127 0.0811467407 5.789186e-01 0.756462901 15 22494900 22494955 56 + 1.077 0.995 -0.299
ENSG00000276550 E009 10.2719524 0.0946623914 7.001222e-01 0.835712779 15 22495570 22495672 103 + 1.062 1.006 -0.204
ENSG00000276550 E010 5.5582265 0.0351934272 6.201782e-01 0.783952411 15 22516876 22516908 33 + 0.742 0.817 0.298
ENSG00000276550 E011 4.3824408 0.0063046768 3.612345e-01 0.596709660 15 22516909 22516990 82 + 0.617 0.751 0.561
ENSG00000276550 E012 21.1770272 0.0133414968 3.415258e-02 0.139259823 15 22534068 22534243 176 + 1.434 1.244 -0.661
ENSG00000276550 E013 32.6867566 0.0153156482 1.353229e-01 0.340256698 15 22537438 22537608 171 + 1.575 1.456 -0.411
ENSG00000276550 E014 8.2698188 0.1641599114 8.165586e-01 0.906184338 15 22537993 22538096 104 + 0.970 0.921 -0.181
ENSG00000276550 E015 0.0000000       15 22539090 22539096 7 +      
ENSG00000276550 E016 2.3002016 0.1261443868 8.835691e-01 0.943144328 15 22539097 22539247 151 + 0.516 0.488 -0.137
ENSG00000276550 E017 5.0663042 0.0549674222 9.650952e-01 0.984473401 15 22541995 22542209 215 + 0.775 0.776 0.007
ENSG00000276550 E018 19.1082813 0.0071974569 2.019776e-02 0.096585587 15 22542483 22542615 133 + 1.410 1.204 -0.720
ENSG00000276550 E019 39.2007513 0.0075066042 1.618719e-03 0.014456454 15 22542723 22542850 128 + 1.711 1.499 -0.725
ENSG00000276550 E020 38.6527436 0.0076711387 1.148361e-02 0.064326303 15 22542943 22543138 196 + 1.679 1.512 -0.570
ENSG00000276550 E021 20.9028195 0.0074681211 1.064361e-01 0.293063907 15 22545767 22545900 134 + 1.417 1.273 -0.503
ENSG00000276550 E022 20.8493088 0.0185900090 5.087694e-02 0.181748432 15 22546430 22546600 171 + 1.445 1.249 -0.681
ENSG00000276550 E023 7.8558511 0.0054574855 5.514725e-01 0.737318485 15 22546678 22546820 143 + 0.979 0.900 -0.298
ENSG00000276550 E024 5.0221212 0.1656515227 5.296784e-01 0.721830954 15 22546938 22547089 152 + 0.712 0.771 0.238
ENSG00000276550 E025 0.2617363 0.2999873221 4.946277e-01   15 22547852 22547880 29 + 0.000 0.161 11.547
ENSG00000276550 E026 23.5210394 0.0014373323 8.901868e-01 0.946779651 15 22547881 22548072 192 + 1.379 1.362 -0.057
ENSG00000276550 E027 38.1616188 0.0011250585 9.467109e-01 0.975654846 15 22554385 22554572 188 + 1.573 1.562 -0.036
ENSG00000276550 E028 27.0863893 0.0023326783 2.519439e-01 0.489994861 15 22556012 22556204 193 + 1.370 1.446 0.263
ENSG00000276550 E029 8.0678215 0.0068790345 5.777017e-01 0.755596466 15 22556910 22556912 3 + 0.979 0.913 -0.248
ENSG00000276550 E030 42.8630125 0.0008564351 4.168098e-01 0.641228072 15 22556913 22557092 180 + 1.593 1.633 0.136
ENSG00000276550 E031 60.8627581 0.0008093324 5.934763e-01 0.765984397 15 22559789 22559970 182 + 1.754 1.774 0.069
ENSG00000276550 E032 47.5190081 0.0059200466 9.305002e-01 0.967235622 15 22560788 22560935 148 + 1.657 1.661 0.011
ENSG00000276550 E033 16.7460821 0.0021228903 3.626487e-01 0.597876822 15 22560936 22560997 62 + 1.278 1.193 -0.298
ENSG00000276550 E034 17.4411218 0.0251712364 9.673797e-03 0.056719834 15 22560998 22561059 62 + 1.418 1.105 -1.103
ENSG00000276550 E035 14.7343990 0.0027236285 8.289175e-05 0.001279488 15 22561060 22561121 62 + 1.370 1.012 -1.274
ENSG00000276550 E036 14.9511121 0.0027289055 8.096213e-01 0.901928262 15 22561122 22561183 62 + 1.199 1.173 -0.091
ENSG00000276550 E037 18.9153950 0.0018144898 6.366159e-01 0.794771875 15 22561184 22561257 74 + 1.257 1.291 0.119
ENSG00000276550 E038 61.9887921 0.0007737424 6.653851e-01 0.813301689 15 22561258 22561433 176 + 1.767 1.782 0.052
ENSG00000276550 E039 42.7478225 0.0011030704 4.178027e-01 0.641985466 15 22561434 22561454 21 + 1.649 1.599 -0.170
ENSG00000276550 E040 64.8979710 0.0006732063 9.956848e-01 0.999439563 15 22561559 22561789 231 + 1.802 1.795 -0.024
ENSG00000276550 E041 14.9554391 0.0241852899 1.978837e-01 0.427007530 15 22561790 22561895 106 + 1.268 1.114 -0.546
ENSG00000276550 E042 15.7642488 0.0365319811 1.125350e-01 0.303382146 15 22561896 22561934 39 + 1.317 1.117 -0.708
ENSG00000276550 E043 4.6275617 0.0062524943 6.105466e-01 0.777328887 15 22562643 22562731 89 + 0.774 0.694 -0.325
ENSG00000276550 E044 40.6724929 0.0108995708 2.350387e-01 0.470939771 15 22562949 22563087 139 + 1.550 1.626 0.259
ENSG00000276550 E045 51.6398259 0.0008004393 1.117023e-01 0.301901749 15 22564389 22564532 144 + 1.649 1.725 0.259
ENSG00000276550 E046 26.6720322 0.0019756537 1.958569e-01 0.424399132 15 22566305 22566362 58 + 1.353 1.442 0.309
ENSG00000276550 E047 65.2098311 0.0006685657 9.041160e-03 0.054010901 15 22569149 22569291 143 + 1.718 1.835 0.397
ENSG00000276550 E048 111.9656015 0.0004689694 4.075309e-02 0.156671607 15 22572929 22573181 253 + 1.985 2.053 0.226
ENSG00000276550 E049 82.6420271 0.0055183330 2.287716e-01 0.463780096 15 22573279 22573402 124 + 1.851 1.919 0.230
ENSG00000276550 E050 54.5752985 0.0121379307 2.152549e-01 0.447816208 15 22573403 22573415 13 + 1.652 1.750 0.332
ENSG00000276550 E051 54.8740698 0.0064445836 2.714395e-01 0.511342534 15 22573975 22574073 99 + 1.672 1.746 0.252
ENSG00000276550 E052 0.5283420 0.1483558822 3.024387e-01   15 22574660 22574712 53 + 0.280 0.091 -1.963
ENSG00000276550 E053 0.5365243 0.0213253040 9.806157e-01   15 22576115 22576205 91 + 0.161 0.166 0.049
ENSG00000276550 E054 2.9594187 0.0101850180 2.549568e-02 0.113732561 15 22576759 22577158 400 + 0.774 0.419 -1.603
ENSG00000276550 E055 20.4494480 0.0020025067 1.198696e-01 0.315655449 15 22577159 22577332 174 + 1.223 1.344 0.423
ENSG00000276550 E056 7.9108488 0.1719336972 8.694265e-01 0.935556717 15 22577430 22577555 126 + 0.934 0.933 -0.004
ENSG00000276550 E057 0.3447487 0.0393226794 4.382987e-01   15 22579348 22579477 130 + 0.000 0.166 12.301
ENSG00000276550 E058 19.4906016 0.1592698568 7.003443e-01 0.835854489 15 22579584 22579678 95 + 1.375 1.240 -0.471
ENSG00000276550 E059 24.3930731 0.0977812284 3.615420e-01 0.596938831 15 22579679 22579723 45 + 1.501 1.313 -0.651
ENSG00000276550 E060 0.1723744 0.0326491905 8.034254e-01   15 22579724 22579813 90 + 0.000 0.091 11.365
ENSG00000276550 E061 36.8852030 0.1373249410 4.127073e-01 0.638154160 15 22587344 22587391 48 + 1.678 1.479 -0.679
ENSG00000276550 E062 11.2357225 0.0056091573 5.303700e-02 0.186826453 15 22587392 22587876 485 + 1.186 0.982 -0.741
ENSG00000276550 E063 53.6450462 0.0007175578 3.614621e-01 0.596899719 15 22589680 22589942 263 + 1.687 1.727 0.138
ENSG00000276550 E064 298.5494804 0.0014952881 1.325355e-03 0.012350514 15 22589943 22590820 878 + 2.406 2.477 0.235