ENSG00000276256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.33726.10 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 0.2857405 0.8401006 0.4173151 0.58295026 0.29870490 -0.9923333 0.03873750 0.15436667 0.02300000 -0.131366667 0.8269587348 3.35768e-05    
MSTRG.33726.11 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 2.1278671 1.3963065 2.3110310 0.71221111 0.27476563 0.7228548 0.17992917 0.20526667 0.12846667 -0.076800000 1.0000000000 3.35768e-05    
MSTRG.33726.13 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 2.0525181 1.0249902 2.8164748 0.51606815 0.30118253 1.4493866 0.17005417 0.14833333 0.15840000 0.010066667 0.9500941048 3.35768e-05    
MSTRG.33726.2 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 1.1194242 0.2248369 2.3486974 0.12172455 0.18149941 3.3282594 0.08321667 0.03446667 0.13300000 0.098533333 0.2338653062 3.35768e-05 FALSE  
MSTRG.33726.3 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 1.4737078 0.9236995 2.6884169 0.15226269 0.04514691 1.5310830 0.11931250 0.15046667 0.15106667 0.000600000 0.9929737420 3.35768e-05 FALSE  
MSTRG.33726.4 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 1.0523783 0.4228240 1.8121527 0.04097496 0.43577874 2.0737914 0.08762500 0.06656667 0.10213333 0.035566667 0.7750373348 3.35768e-05    
MSTRG.33726.6 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 1.0178675 0.5073823 1.5380552 0.26182983 0.35174842 1.5811544 0.08762500 0.09010000 0.08446667 -0.005633333 0.9493964547 3.35768e-05 FALSE  
MSTRG.33726.9 ENSG00000276256 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   11.99228 6.385006 17.87271 0.6988542 0.8686721 1.483547 1.2224078 0.0000000 1.6759721 0.00000000 0.44080121 7.3974369 0.08485417 0.00000000 0.09546667 0.095466667 0.0000335768 3.35768e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000276256 E001 0.0000000       GL000195.1 1367 1367 1 -      
ENSG00000276256 E002 0.1779838 0.0405698381 1.0000000000   GL000195.1 1368 1498 131 - 0.089 0.000 -8.145
ENSG00000276256 E003 0.0000000       GL000195.1 1647 1768 122 -      
ENSG00000276256 E004 0.3206185 0.0274424043 0.4880280854   GL000195.1 1769 2027 259 - 0.162 0.000 -11.257
ENSG00000276256 E005 0.1426347 0.0319124334 1.0000000000   GL000195.1 2719 2966 248 - 0.089 0.000 -10.324
ENSG00000276256 E006 0.0000000       GL000195.1 13772 13951 180 -      
ENSG00000276256 E007 4.0314088 0.0314448289 0.1912075453 0.418388361 GL000195.1 19565 19683 119 - 0.743 0.518 -0.982
ENSG00000276256 E008 11.6235956 0.0038346568 0.0004646124 0.005351819 GL000195.1 20004 20186 183 - 1.178 0.782 -1.476
ENSG00000276256 E009 0.9528494 0.0225269434 1.0000000000   GL000195.1 28554 28609 56 - 0.280 0.283 0.020
ENSG00000276256 E010 4.1153825 0.0101217534 0.5853112859 0.760501439 GL000195.1 42939 43125 187 - 0.665 0.747 0.337
ENSG00000276256 E011 14.3383709 0.0025229933 0.1177482815 0.312111607 GL000195.1 43126 43200 75 - 1.114 1.255 0.499
ENSG00000276256 E012 15.6913396 0.0026314313 0.1706511987 0.391343393 GL000195.1 43201 44671 1471 - 1.158 1.276 0.420
ENSG00000276256 E013 11.5976255 0.0031132877 0.1286470288 0.329700019 GL000195.1 44672 44923 252 - 1.122 0.967 -0.568
ENSG00000276256 E014 1.3679914 0.0225490842 0.0452261077   GL000195.1 46540 46557 18 - 0.225 0.574 2.018
ENSG00000276256 E015 9.9263020 0.0349072704 0.0015274610 0.013801440 GL000195.1 46558 46741 184 - 0.850 1.240 1.429
ENSG00000276256 E016 7.6699505 0.0218609437 0.0044169904 0.031469482 GL000195.1 46742 46801 60 - 0.775 1.125 1.314
ENSG00000276256 E017 21.1942404 0.0620819319 0.3173478936 0.557315553 GL000195.1 48196 48386 191 - 1.346 1.269 -0.269
ENSG00000276256 E018 60.0516585 0.0007786013 0.0573400572 0.196811863 GL000195.1 48955 49119 165 - 1.791 1.715 -0.255
ENSG00000276256 E019 1.5081547 0.2750120731 0.5708155310 0.750878054 GL000195.1 49120 49164 45 - 0.329 0.462 0.743
ENSG00000276256 E020 5.6873614 0.0966504720 0.7933593119 0.892343394 GL000195.1 74121 74180 60 - 0.803 0.838 0.140
ENSG00000276256 E021 1.9338954 0.0106234744 0.0812210197 0.247300712 GL000195.1 74181 74272 92 - 0.329 0.624 1.501
ENSG00000276256 E022 7.2967036 0.0817703452 0.8573449269 0.929011844 GL000195.1 84144 84251 108 - 0.869 0.930 0.231
ENSG00000276256 E023 23.0551967 0.0024223837 0.3384139073 0.576590099 GL000195.1 86518 86710 193 - 1.386 1.317 -0.242