ENSG00000275895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000610664 ENSG00000275895 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding protein_coding 399.0107 414.5534 280.2541 88.49311 12.09107 -0.5648059 269.8327 293.6547 171.86642 59.79958 6.400888 -0.7727980 0.6684167 0.7125667 0.6137333 -0.09883333 0.01360362 0.01360362 FALSE  
ENST00000619610 ENSG00000275895 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding protein_coding 399.0107 414.5534 280.2541 88.49311 12.09107 -0.5648059 117.7209 112.8493 97.05113 28.51458 5.559275 -0.2175591 0.2998333 0.2657333 0.3460667 0.08033333 0.17506003 0.01360362 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000275895 E001 0.0000000       21 6483714 6484622 909 -      
ENSG00000275895 E002 0.0000000       21 6484623 6484623 1 -      
ENSG00000275895 E003 0.0000000       21 6484624 6484625 2 -      
ENSG00000275895 E004 0.0000000       21 6484626 6484629 4 -      
ENSG00000275895 E005 0.0000000       21 6484630 6484660 31 -      
ENSG00000275895 E006 0.0000000       21 6484661 6484708 48 -      
ENSG00000275895 E007 0.0000000       21 6484709 6484854 146 -      
ENSG00000275895 E008 0.0000000       21 6484855 6484916 62 -      
ENSG00000275895 E009 0.0000000       21 6484917 6485560 644 -      
ENSG00000275895 E010 2.2142929 0.025222058 0.365045406 0.59998748 21 6485561 6486137 577 - 0.551 0.434 -0.575
ENSG00000275895 E011 0.3337900 0.027503601 0.794202088   21 6486138 6486230 93 - 0.135 0.109 -0.355
ENSG00000275895 E012 0.6785387 0.407368914 0.725598587   21 6486322 6486455 134 - 0.135 0.273 1.259
ENSG00000275895 E013 8.1563311 0.051225163 0.478205028 0.68593182 21 6486456 6487106 651 - 0.970 0.935 -0.131
ENSG00000275895 E014 3.7953073 0.017925287 0.551689620 0.73747250 21 6487107 6487205 99 - 0.699 0.648 -0.217
ENSG00000275895 E015 1.8858521 0.013510987 0.742385290 0.86188599 21 6487206 6487362 157 - 0.391 0.477 0.455
ENSG00000275895 E016 1.4396852 0.013720308 0.127073174 0.32715079 21 6487363 6487370 8 - 0.504 0.268 -1.356
ENSG00000275895 E017 2.1068900 0.010319316 0.727024163 0.85244046 21 6487371 6487412 42 - 0.504 0.477 -0.133
ENSG00000275895 E018 0.3150090 0.027442404 0.799294295   21 6487413 6488059 647 - 0.135 0.109 -0.353
ENSG00000275895 E019 11.3287661 0.004795959 0.001909027 0.01646588 21 6489291 6492129 2839 - 1.212 0.980 -0.840
ENSG00000275895 E020 0.0000000       21 6492130 6492130 1 -      
ENSG00000275895 E021 2.0420230 0.159089553 0.024323173 0.11009446 21 6492131 6492197 67 - 0.134 0.641 3.217
ENSG00000275895 E022 0.0000000       21 6492198 6492254 57 -      
ENSG00000275895 E023 0.0000000       21 6492255 6492292 38 -      
ENSG00000275895 E024 0.0000000       21 6492293 6493043 751 -      
ENSG00000275895 E025 1.1434418 0.162724525 0.165556371   21 6493044 6493110 67 - 0.134 0.434 2.241
ENSG00000275895 E026 3.1978935 0.467488288 0.070285919 0.22533670 21 6493111 6495992 2882 - 0.797 0.393 -1.840
ENSG00000275895 E027 7.0624180 0.133462430 0.064949712 0.21379196 21 6495993 6496080 88 - 0.661 1.029 1.435
ENSG00000275895 E028 1.3088171 0.015378759 0.054423186   21 6496081 6496930 850 - 0.504 0.196 -1.939
ENSG00000275895 E029 10.6266907 0.100647067 0.005657118 0.03802378 21 6499129 6499261 133 - 0.752 1.208 1.706