ENSG00000275066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612223 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding protein_coding 5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 1.9056292 1.3106724 2.0169775 0.2430502 0.20034695 0.6180575 0.36114167 0.27896667 0.26786667 -0.011100000 9.844127e-01 5.724463e-16 FALSE TRUE
ENST00000614196 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding protein_coding 5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.4123447 0.6459614 0.5418160 0.3393232 0.09114904 -0.2494236 0.07859583 0.14856667 0.07223333 -0.076333333 9.776489e-01 5.724463e-16 FALSE FALSE
ENST00000616179 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding protein_coding 5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.4494168 0.3295632 0.7110871 0.3295632 0.57833357 1.0864932 0.07493333 0.06516667 0.08776667 0.022600000 8.487696e-01 5.724463e-16 FALSE TRUE
MSTRG.14217.10 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.4117547 0.2950434 0.0000000 0.2950434 0.00000000 -4.9309428 0.07275000 0.04596667 0.00000000 -0.045966667 8.157294e-01 5.724463e-16 FALSE TRUE
MSTRG.14217.12 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.1318446 0.1550459 0.0000000 0.1550459 0.00000000 -4.0447954 0.02447500 0.05243333 0.00000000 -0.052433333 8.467030e-01 5.724463e-16 FALSE TRUE
MSTRG.14217.13 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.3908423 0.0000000 1.8024212 0.0000000 0.09821910 7.5017745 0.05174167 0.00000000 0.23770000 0.237700000 5.724463e-16 5.724463e-16 FALSE TRUE
MSTRG.14217.5 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.6194614 0.3330835 0.4058489 0.1693855 0.40584887 0.2774997 0.10415833 0.05963333 0.04990000 -0.009733333 7.546931e-01 5.724463e-16 FALSE TRUE
MSTRG.14217.6 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.4702485 0.1972622 0.8387599 0.1972622 0.48283787 2.0338998 0.08441250 0.03900000 0.11213333 0.073133333 7.522619e-01 5.724463e-16 TRUE TRUE
MSTRG.14217.7 ENSG00000275066 HEK293_OSMI2_6hA HEK293_TMG_6hB SYNRG protein_coding   5.631061 4.811643 7.598032 1.006907 0.4274112 0.6579986 0.2598070 1.1742027 0.3132441 0.4417064 0.31324409 -1.8732202 0.04420833 0.22256667 0.04640000 -0.176166667 2.329186e-01 5.724463e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000275066 E001 25.3568169 0.0148738458 0.048309628 0.17573657 17 37514807 37515368 562 - 1.324 1.499 0.608
ENSG00000275066 E002 13.9505150 0.0414601606 0.157337113 0.37272393 17 37515369 37515444 76 - 1.082 1.251 0.602
ENSG00000275066 E003 11.7692722 0.0360316912 0.071683759 0.22818791 17 37515445 37515568 124 - 0.979 1.204 0.816
ENSG00000275066 E004 63.6575809 0.0009498671 0.765646209 0.87606261 17 37515569 37517186 1618 - 1.810 1.796 -0.046
ENSG00000275066 E005 16.1057172 0.0087085360 0.034396768 0.13996517 17 37517187 37517342 156 - 1.305 1.096 -0.740
ENSG00000275066 E006 20.8105114 0.1026512282 0.553161052 0.73850737 17 37517343 37517522 180 - 1.380 1.271 -0.379
ENSG00000275066 E007 9.9099344 0.0510543254 0.843457138 0.92134327 17 37517523 37517580 58 - 1.026 1.041 0.055
ENSG00000275066 E008 18.5880206 0.0092690772 0.406894983 0.63368980 17 37517581 37517829 249 - 1.324 1.244 -0.278
ENSG00000275066 E009 33.4277429 0.0012397456 0.285179113 0.52576610 17 37517830 37518400 571 - 1.560 1.495 -0.223
ENSG00000275066 E010 9.7001230 0.0036880220 0.693101528 0.83113930 17 37518401 37518460 60 - 1.037 0.994 -0.158
ENSG00000275066 E011 35.7684420 0.0011508192 0.430252338 0.65128840 17 37518461 37518687 227 - 1.543 1.590 0.162
ENSG00000275066 E012 28.4707178 0.0016070116 0.220413681 0.45404860 17 37518688 37518768 81 - 1.422 1.505 0.285
ENSG00000275066 E013 21.6854893 0.0049299038 0.172476127 0.39378686 17 37518769 37518821 53 - 1.293 1.405 0.390
ENSG00000275066 E014 27.5040562 0.0014622836 0.011032837 0.06250224 17 37518822 37518886 65 - 1.368 1.538 0.587
ENSG00000275066 E015 43.1041025 0.0010044915 0.004182523 0.03017497 17 37518887 37519009 123 - 1.570 1.724 0.523
ENSG00000275066 E016 34.8068985 0.0013947186 0.682600381 0.82434213 17 37519010 37519071 62 - 1.539 1.565 0.088
ENSG00000275066 E017 21.1591785 0.0016658896 0.047437565 0.17360176 17 37520179 37520214 36 - 1.267 1.416 0.518
ENSG00000275066 E018 44.3787919 0.0009508946 0.253863199 0.49225848 17 37520538 37520648 111 - 1.628 1.689 0.206
ENSG00000275066 E019 1.1021233 0.0153787590 0.143037150   17 37529783 37529851 69 - 0.194 0.453 1.705
ENSG00000275066 E020 43.4656463 0.0010021055 0.130589444 0.33271459 17 37535979 37536085 107 - 1.605 1.686 0.277
ENSG00000275066 E021 38.3012796 0.0010792750 0.087404208 0.25899921 17 37536086 37536127 42 - 1.543 1.641 0.335
ENSG00000275066 E022 0.9113432 0.0169378554 0.623379434   17 37536128 37537478 1351 - 0.328 0.240 -0.616
ENSG00000275066 E023 49.3895319 0.0007634035 0.114559592 0.30675244 17 37538324 37538420 97 - 1.662 1.742 0.270
ENSG00000275066 E024 37.8306847 0.0065924480 0.058390533 0.19916557 17 37539192 37539245 54 - 1.525 1.657 0.450
ENSG00000275066 E025 47.3909271 0.0016918628 0.404312263 0.63177697 17 37540380 37540480 101 - 1.662 1.708 0.157
ENSG00000275066 E026 35.9750930 0.0011320624 0.573751227 0.75282619 17 37540481 37540543 63 - 1.580 1.547 -0.110
ENSG00000275066 E027 1.5703160 0.1294948051 0.238435308 0.47483849 17 37540626 37541971 1346 - 0.508 0.242 -1.575
ENSG00000275066 E028 97.4427305 0.0004275078 0.825982571 0.91147698 17 37541972 37542427 456 - 1.986 1.994 0.028
ENSG00000275066 E029 11.4218033 0.0027044695 0.742678601 0.86208208 17 37542428 37542430 3 - 1.100 1.068 -0.116
ENSG00000275066 E030 29.6043819 0.0022778876 0.693961804 0.83163949 17 37542431 37542565 135 - 1.487 1.463 -0.083
ENSG00000275066 E031 73.7746478 0.0006718646 0.823280229 0.90982307 17 37553115 37553415 301 - 1.864 1.873 0.033
ENSG00000275066 E032 107.2608166 0.0006573004 0.634598992 0.79329779 17 37553416 37553986 571 - 2.020 2.038 0.060
ENSG00000275066 E033 30.5356577 0.0014390942 0.721011826 0.84880829 17 37553987 37554059 73 - 1.486 1.510 0.080
ENSG00000275066 E034 0.0000000       17 37557140 37557203 64 -      
ENSG00000275066 E035 23.4428579 0.0015231274 0.462946411 0.67510732 17 37561195 37561257 63 - 1.357 1.410 0.184
ENSG00000275066 E036 37.4299190 0.0010212587 0.917465195 0.96093926 17 37561471 37561589 119 - 1.580 1.586 0.023
ENSG00000275066 E037 0.6592102 0.1591655420 0.791348037   17 37566849 37568790 1942 - 0.196 0.239 0.359
ENSG00000275066 E038 38.6545132 0.0011701077 0.333317993 0.57192428 17 37568791 37568924 134 - 1.620 1.565 -0.186
ENSG00000275066 E039 56.1797100 0.0008660165 0.026872869 0.11792024 17 37570637 37570885 249 - 1.798 1.692 -0.358
ENSG00000275066 E040 28.9902448 0.0092712359 0.192690462 0.42037082 17 37571791 37571832 42 - 1.518 1.419 -0.341
ENSG00000275066 E041 44.7179697 0.0009572656 0.356332795 0.59282213 17 37571833 37571987 155 - 1.678 1.630 -0.163
ENSG00000275066 E042 25.6562621 0.0025332539 0.640026815 0.79691527 17 37576341 37576418 78 - 1.407 1.440 0.113
ENSG00000275066 E043 0.0000000       17 37576419 37576480 62 -      
ENSG00000275066 E044 23.0746736 0.0024578747 0.819908748 0.90801964 17 37577380 37577446 67 - 1.368 1.384 0.058
ENSG00000275066 E045 35.0160430 0.0010107653 0.187651909 0.41395646 17 37577447 37577613 167 - 1.583 1.505 -0.268
ENSG00000275066 E046 27.1409919 0.0014206840 0.006038575 0.03991472 17 37579132 37579434 303 - 1.517 1.328 -0.655
ENSG00000275066 E047 0.8864051 0.0172671820 0.615895850   17 37584322 37584647 326 - 0.328 0.239 -0.619
ENSG00000275066 E048 32.6080579 0.0010590928 0.004811392 0.03359586 17 37584648 37584759 112 - 1.592 1.416 -0.606
ENSG00000275066 E049 21.0471345 0.0017300001 0.055031593 0.19141076 17 37585325 37585341 17 - 1.393 1.245 -0.516
ENSG00000275066 E050 33.6175855 0.0012406682 0.058718553 0.19989898 17 37585342 37585430 89 - 1.580 1.463 -0.402
ENSG00000275066 E051 36.5852025 0.0015099082 0.058843886 0.20015327 17 37586419 37586549 131 - 1.614 1.500 -0.391
ENSG00000275066 E052 26.9828842 0.0015608387 0.018870801 0.09199077 17 37596223 37596341 119 - 1.506 1.343 -0.563
ENSG00000275066 E053 5.7651427 0.0052365451 0.393639901 0.62323779 17 37596342 37596344 3 - 0.875 0.763 -0.439
ENSG00000275066 E054 8.6591127 0.0040119058 0.084844695 0.25432792 17 37600363 37600403 41 - 1.059 0.861 -0.738
ENSG00000275066 E055 0.1426347 0.0322263560 0.634748945   17 37600404 37600988 585 - 0.108 0.000 -8.993
ENSG00000275066 E056 8.4548354 0.0036783456 0.172507324 0.39381249 17 37609279 37609367 89 - 1.037 0.882 -0.577
ENSG00000275066 E057 4.2442254 0.0081429286 0.520704164 0.71539652 17 37609368 37609472 105 - 0.764 0.670 -0.384