ENSG00000275052

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000611717 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding protein_coding 17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 1.0798983 0.2072849 2.195139 0.15121092 0.4552462 3.343210 0.11014167 0.04183333 0.05896667 0.01713333 0.834766903 0.004189987 FALSE TRUE
ENST00000612688 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding processed_transcript 17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 0.9380681 0.3961941 1.584395 0.04385066 0.1423798 1.972768 0.08268333 0.08506667 0.04236667 -0.04270000 0.242222300 0.004189987 TRUE FALSE
ENST00000616288 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding protein_coding 17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 5.6819082 1.1629288 14.595469 0.25587183 0.6485798 3.638321 0.24139167 0.23196667 0.38890000 0.15693333 0.004189987 0.004189987 FALSE TRUE
ENST00000616407 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding protein_coding 17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 2.7430758 1.0862428 4.571518 0.35180474 0.6000614 2.063258 0.14030417 0.20210000 0.12153333 -0.08056667 0.391131423 0.004189987 FALSE TRUE
MSTRG.18430.3 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding   17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 0.1462322 0.3720109 0.000000 0.21072842 0.0000000 -5.255542 0.03148750 0.06076667 0.00000000 -0.06076667 0.026389999 0.004189987 FALSE TRUE
MSTRG.18430.8 ENSG00000275052 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP4R3B protein_coding   17.00695 5.022773 37.49869 1.11869 0.6095075 2.8978 4.0942856 1.5299344 10.159841 0.55426307 0.7729566 2.723356 0.28687917 0.28400000 0.27060000 -0.01340000 0.995100197 0.004189987 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000275052 E001 13.7249148 0.605685577 3.422573e-01 5.799789e-01 2 55547292 55547450 159 - 0.944 1.294 1.261
ENSG00000275052 E002 41.5090416 0.832600241 2.174246e-01 4.502946e-01 2 55547451 55547732 282 - 1.356 1.845 1.670
ENSG00000275052 E003 50.9158113 0.852198856 1.695323e-01 3.899268e-01 2 55547733 55548377 645 - 1.428 1.960 1.808
ENSG00000275052 E004 347.2599340 1.796820050 4.983100e-01 6.996768e-01 2 55548378 55549569 1192 - 2.316 2.610 0.982
ENSG00000275052 E005 47.6159758 0.868986360 3.307630e-01 5.697119e-01 2 55549570 55549612 43 - 1.467 1.750 0.964
ENSG00000275052 E006 188.6083055 1.581869558 4.808128e-01 6.876337e-01 2 55549613 55550006 394 - 2.059 2.322 0.878
ENSG00000275052 E007 169.1223883 0.013908351 1.177914e-01 3.122065e-01 2 55558775 55558968 194 - 2.032 2.198 0.554
ENSG00000275052 E008 176.0890083 0.008529507 3.130559e-01 5.533452e-01 2 55564313 55564470 158 - 2.070 2.096 0.088
ENSG00000275052 E009 80.7311770 0.015910881 9.898937e-02 2.800324e-01 2 55564471 55564476 6 - 1.747 1.692 -0.185
ENSG00000275052 E010 80.3859885 0.009313626 4.363716e-03 3.116969e-02 2 55564477 55564497 21 - 1.753 1.614 -0.472
ENSG00000275052 E011 175.8172957 0.012242875 5.573640e-02 1.930241e-01 2 55564902 55565041 140 - 2.078 2.032 -0.157
ENSG00000275052 E012 1.1965423 0.015151094 3.425257e-01   2 55568029 55568193 165 - 0.207 0.433 1.491
ENSG00000275052 E013 173.1108441 0.020471272 2.805257e-01 5.207323e-01 2 55568194 55568363 170 - 2.067 2.055 -0.042
ENSG00000275052 E014 155.5263985 0.012923815 9.147197e-03 5.448374e-02 2 55573619 55573777 159 - 2.031 1.931 -0.336
ENSG00000275052 E015 99.4634423 0.007664473 7.431486e-02 2.333786e-01 2 55577315 55577356 42 - 1.833 1.801 -0.110
ENSG00000275052 E016 75.6682992 0.003435802 2.004353e-01 4.302652e-01 2 55578247 55578342 96 - 1.714 1.711 -0.010
ENSG00000275052 E017 123.5108732 0.011686146 2.063889e-02 9.814512e-02 2 55579679 55579781 103 - 1.931 1.853 -0.264
ENSG00000275052 E018 139.7093266 0.013559181 1.323486e-02 7.138708e-02 2 55581567 55581698 132 - 1.986 1.891 -0.322
ENSG00000275052 E019 119.3200527 0.020804090 7.545249e-03 4.723722e-02 2 55585051 55585167 117 - 1.924 1.772 -0.513
ENSG00000275052 E020 128.4621466 0.013119305 1.231109e-02 6.768449e-02 2 55586618 55586734 117 - 1.950 1.845 -0.355
ENSG00000275052 E021 107.3079839 0.006525123 1.101677e-02 6.244385e-02 2 55588879 55588956 78 - 1.871 1.784 -0.294
ENSG00000275052 E022 2.4700803 0.164859495 3.056644e-01 5.462997e-01 2 55591505 55591568 64 - 0.386 0.646 1.256
ENSG00000275052 E023 178.1017792 0.011097840 2.665750e-04 3.391307e-03 2 55598416 55598697 282 - 2.096 1.938 -0.533
ENSG00000275052 E024 53.0257127 0.005764899 3.545399e-02 1.427634e-01 2 55598698 55598703 6 - 1.571 1.478 -0.319
ENSG00000275052 E025 183.0502086 0.012150393 1.974989e-03 1.690176e-02 2 55598704 55599039 336 - 2.104 1.983 -0.405
ENSG00000275052 E026 105.6595949 0.013842742 2.488271e-03 2.025722e-02 2 55603978 55604076 99 - 1.871 1.718 -0.517
ENSG00000275052 E027 60.9262212 0.027164267 1.428871e-01 3.518017e-01 2 55614176 55615450 1275 - 1.586 1.799 0.721
ENSG00000275052 E028 93.3320578 0.011299070 7.414406e-03 4.662606e-02 2 55615451 55615506 56 - 1.816 1.688 -0.433
ENSG00000275052 E029 13.2495894 0.398275191 3.155608e-03 2.434004e-02 2 55616518 55616617 100 - 0.717 1.620 3.273
ENSG00000275052 E030 211.4489001 0.003044522 1.417688e-07 5.080312e-06 2 55617144 55617978 835 - 2.108 2.386 0.928
ENSG00000275052 E031 0.7796672 0.040571895 2.129870e-02   2 55617979 55618065 87 - 0.095 0.552 3.398
ENSG00000275052 E032 3.1663101 0.214065600 1.372564e-01 3.433342e-01 2 55618066 55618094 29 - 0.439 0.786 1.545
ENSG00000275052 E033 13.8879581 0.029510518 3.194433e-06 7.832633e-05 2 55618095 55618750 656 - 0.868 1.490 2.229
ENSG00000275052 E034 5.6674989 0.067988857 7.407806e-01 8.609176e-01 2 55618751 55619758 1008 - 0.659 0.786 0.519