ENSG00000272693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.29939.2 ENSG00000272693 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   4.242309 4.151228 4.45445 0.05276755 0.4501121 0.1014731 0.5369299 0.8963158 0.0000000 0.50075977 0.00000000 -6.5019420 0.1265375 0.21526667 0.0000000 -0.21526667 0.3275062 0.0286384   FALSE
MSTRG.29939.4 ENSG00000272693 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   4.242309 4.151228 4.45445 0.05276755 0.4501121 0.1014731 0.7463593 0.4710332 1.0062017 0.29938814 0.05812905 1.0789786 0.1715500 0.11406667 0.2285333 0.11446667 0.6624672 0.0286384   FALSE
MSTRG.29939.5 ENSG00000272693 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   4.242309 4.151228 4.45445 0.05276755 0.4501121 0.1014731 0.9499329 0.8570439 1.7140638 0.05768644 0.15819069 0.9916362 0.2215875 0.20676667 0.3864667 0.17970000 0.0286384 0.0286384   FALSE
MSTRG.29939.6 ENSG00000272693 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   4.242309 4.151228 4.45445 0.05276755 0.4501121 0.1014731 0.6926423 0.4144103 0.7583524 0.23340065 0.43530984 0.8563083 0.1571000 0.09883333 0.1587000 0.05986667 0.9664213 0.0286384   FALSE
MSTRG.29939.7 ENSG00000272693 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   4.242309 4.151228 4.45445 0.05276755 0.4501121 0.1014731 0.9190313 1.2950493 0.5362677 0.10207279 0.31764955 -1.2564243 0.2201917 0.31266667 0.1219000 -0.19076667 0.5429200 0.0286384   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000272693 E001 0.3040503 0.027442404 0.192858824   7 65647010 65648041 1032 - 0.217 0.000 -12.859
ENSG00000272693 E002 0.3040503 0.027442404 0.192858824   7 65648335 65648420 86 - 0.217 0.000 -12.859
ENSG00000272693 E003 0.1426347 0.032649190 0.471694052   7 65648845 65648981 137 - 0.122 0.000 -11.859
ENSG00000272693 E004 0.1308682 0.032602958 0.509193663   7 65649418 65649550 133 - 0.000 0.121 11.797
ENSG00000272693 E005 0.1308682 0.032602958 0.509193663   7 65671151 65671239 89 - 0.000 0.121 11.797
ENSG00000272693 E006 1.0172733 0.052681343 0.679368984   7 65695878 65695946 69 - 0.361 0.291 -0.441
ENSG00000272693 E007 4.2017761 0.007093693 0.954138509 0.97897120 7 65697862 65699818 1957 - 0.717 0.714 -0.010
ENSG00000272693 E008 3.6554533 0.035386843 0.752108210 0.86798780 7 65715686 65715848 163 - 0.689 0.656 -0.139
ENSG00000272693 E009 1.6065227 0.016735029 0.188486710 0.41505711 7 65721932 65721942 11 - 0.515 0.293 -1.238
ENSG00000272693 E010 9.6364004 0.004284639 0.193978570 0.42210093 7 65721943 65722124 182 - 1.091 0.970 -0.442
ENSG00000272693 E011 9.2258228 0.003777770 0.023509310 0.10757839 7 65722125 65722288 164 - 1.113 0.889 -0.829
ENSG00000272693 E012 17.8164140 0.003615506 0.180533348 0.40465943 7 65726771 65726944 174 - 1.330 1.239 -0.317
ENSG00000272693 E013 12.7452653 0.003014443 0.718844710 0.84747005 7 65727055 65727108 54 - 1.155 1.131 -0.084
ENSG00000272693 E014 8.9007266 0.004161170 0.753622870 0.86892094 7 65750883 65750953 71 - 0.974 1.014 0.147
ENSG00000272693 E015 4.9058501 0.007329073 0.080680845 0.24618196 7 65762931 65763017 87 - 0.627 0.871 0.990
ENSG00000272693 E016 7.7740385 0.114415112 0.069689421 0.22415323 7 65763413 65763506 94 - 0.758 1.067 1.172
ENSG00000272693 E017 3.0998699 0.236415136 0.417925579 0.64208381 7 65770467 65770472 6 - 0.464 0.707 1.099
ENSG00000272693 E018 8.0145882 0.005746056 0.004687522 0.03294496 7 65770473 65770810 338 - 0.743 1.077 1.271