ENSG00000272645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000608760 ENSG00000272645 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene retained_intron 15.28189 23.88132 9.770237 5.570139 0.1434344 -1.288545 4.5507559 5.8383010 2.4314776 2.91476193 0.3303398 -1.260263 0.2708958 0.21860000 0.2482333 0.02963333 9.179877e-01 1.740777e-06 FALSE TRUE
ENST00000685304 ENSG00000272645 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 15.28189 23.88132 9.770237 5.570139 0.1434344 -1.288545 1.0578133 0.5080706 1.7638946 0.50807057 0.1841520 1.775700 0.0831875 0.01456667 0.1811000 0.16653333 7.591001e-02 1.740777e-06   FALSE
MSTRG.3119.1 ENSG00000272645 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   15.28189 23.88132 9.770237 5.570139 0.1434344 -1.288545 2.2380991 5.5671296 0.3855211 0.69696736 0.3855211 -3.817696 0.1472667 0.24923333 0.0388000 -0.21043333 1.621313e-01 1.740777e-06 FALSE TRUE
MSTRG.3119.13 ENSG00000272645 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   15.28189 23.88132 9.770237 5.570139 0.1434344 -1.288545 0.6306025 1.1302490 0.0000000 0.05655648 0.0000000 -6.833205 0.0366625 0.05156667 0.0000000 -0.05156667 1.740777e-06 1.740777e-06 FALSE FALSE
MSTRG.3119.4 ENSG00000272645 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   15.28189 23.88132 9.770237 5.570139 0.1434344 -1.288545 0.2786543 1.0777963 0.0000000 0.04112500 0.0000000 -6.765265 0.0161625 0.05036667 0.0000000 -0.05036667 1.326476e-05 1.740777e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000272645 E001 11.9454250 0.046324981 0.0134136251 0.072072120 1 223951394 223951478 85 - 0.646 1.057 1.602
ENSG00000272645 E002 34.3510476 0.003896913 0.0001310071 0.001873202 1 223951479 223951498 20 - 1.126 1.481 1.245
ENSG00000272645 E003 115.7850778 0.147871511 0.0188771777 0.092009039 1 223951499 223951771 273 - 1.649 1.997 1.173
ENSG00000272645 E004 52.0623033 0.001404414 0.0004191514 0.004917211 1 223951772 223951782 11 - 1.399 1.648 0.856
ENSG00000272645 E005 63.7125045 0.002671835 0.0001862866 0.002521380 1 223951783 223951819 37 - 1.484 1.734 0.851
ENSG00000272645 E006 54.3460145 0.014737637 0.0215557169 0.101139871 1 223951820 223951838 19 - 1.471 1.660 0.646
ENSG00000272645 E007 75.7665419 0.140625695 0.1488903903 0.360719767 1 223951839 223951890 52 - 1.638 1.794 0.527
ENSG00000272645 E008 62.2735309 0.039894011 0.0532039209 0.187262798 1 223951891 223951911 21 - 1.541 1.713 0.585
ENSG00000272645 E009 55.9954307 0.105531583 0.2333991300 0.469043731 1 223951912 223951915 4 - 1.556 1.658 0.348
ENSG00000272645 E010 69.3428222 0.175512624 0.3441389018 0.581727790 1 223951916 223951944 29 - 1.682 1.743 0.204
ENSG00000272645 E011 58.0442053 0.118085329 0.4307510917 0.651705061 1 223951945 223951955 11 - 1.626 1.664 0.128
ENSG00000272645 E012 70.1348441 0.155220678 0.3085753311 0.549132742 1 223951956 223951997 42 - 1.669 1.751 0.278
ENSG00000272645 E013 50.0484145 0.041140764 0.4954349431 0.697739736 1 223951998 223952001 4 - 1.564 1.601 0.126
ENSG00000272645 E014 52.2503231 0.064436487 0.4850085413 0.690569501 1 223952002 223952011 10 - 1.585 1.619 0.115
ENSG00000272645 E015 48.2349346 0.004293392 0.3006896174 0.541155911 1 223952012 223952021 10 - 1.521 1.592 0.243
ENSG00000272645 E016 42.5523410 0.001167081 0.5570950331 0.741205868 1 223952022 223952022 1 - 1.494 1.532 0.130
ENSG00000272645 E017 44.1709672 0.001187695 0.4821053421 0.688486952 1 223952023 223952030 8 - 1.504 1.549 0.156
ENSG00000272645 E018 51.1313469 0.067329210 0.5209441198 0.715527869 1 223952031 223952074 44 - 1.585 1.608 0.080
ENSG00000272645 E019 72.6597166 0.199143900 0.3533672589 0.590294095 1 223952075 223952265 191 - 1.706 1.762 0.188
ENSG00000272645 E020 33.1592240 0.045306224 0.2306188591 0.465848943 1 223952266 223952291 26 - 1.328 1.437 0.379
ENSG00000272645 E021 26.7142419 0.045502318 0.8440964631 0.921629225 1 223952292 223952384 93 - 1.313 1.335 0.078
ENSG00000272645 E022 34.5420258 0.082526160 0.4928262320 0.695885896 1 223952385 223952442 58 - 1.365 1.450 0.295
ENSG00000272645 E023 48.7905300 0.164184372 0.7471123511 0.864973179 1 223952443 223952667 225 - 1.548 1.591 0.146
ENSG00000272645 E024 85.4617941 0.243035182 0.3688981335 0.603131623 1 223952668 223952867 200 - 1.751 1.835 0.285
ENSG00000272645 E025 25.6715187 0.039410062 0.8828588701 0.942788486 1 223952868 223952870 3 - 1.328 1.315 -0.045
ENSG00000272645 E026 45.0778360 0.237986165 0.9912406866 0.997378018 1 223952871 223953439 569 - 1.541 1.551 0.036
ENSG00000272645 E027 45.9675589 0.102365468 0.6617000498 0.810911786 1 223954477 223954596 120 - 1.549 1.562 0.044
ENSG00000272645 E028 18.7975466 0.035235114 0.3528764342 0.589915191 1 223954597 223954667 71 - 1.075 1.214 0.496
ENSG00000272645 E029 0.3032425 0.024441170 1.0000000000   1 223955415 223955418 4 - 0.000 0.115 8.130
ENSG00000272645 E030 4.2406612 0.107509912 0.8566707141 0.928644594 1 223955419 223955537 119 - 0.572 0.648 0.334
ENSG00000272645 E031 0.9506365 0.111465930 0.0164899651   1 223958544 223958584 41 - 0.572 0.115 -3.164
ENSG00000272645 E032 2.5130936 0.010171222 0.0552304768 0.191863689 1 223960515 223960584 70 - 0.709 0.374 -1.592
ENSG00000272645 E033 2.1411214 0.147700441 0.4378850926 0.657131195 1 223960585 223960619 35 - 0.568 0.380 -0.951
ENSG00000272645 E034 1.5936384 0.120159659 0.1976288984 0.426616657 1 223960620 223960622 3 - 0.569 0.283 -1.560
ENSG00000272645 E035 2.8605013 0.169602651 0.4068295275 0.633617429 1 223960623 223960700 78 - 0.700 0.453 -1.125
ENSG00000272645 E036 1.2376005 0.056170851 0.8566393664   1 223961064 223961120 57 - 0.227 0.284 0.425
ENSG00000272645 E037 2.0119185 0.010713493 0.0636256398 0.210884654 1 223961121 223961167 47 - 0.647 0.314 -1.693
ENSG00000272645 E038 27.3486751 0.075064578 0.6665286152 0.813997900 1 223961168 223961232 65 - 1.360 1.337 -0.081
ENSG00000272645 E039 72.5775887 0.109198621 0.1555938466 0.370283265 1 223962077 223962273 197 - 1.887 1.716 -0.577
ENSG00000272645 E040 7.2354467 0.539174252 0.8086748647 0.901398004 1 223962475 223962514 40 - 0.725 0.829 0.418
ENSG00000272645 E041 7.8734593 0.119656820 0.8666671126 0.934132250 1 223962515 223962568 54 - 0.710 0.867 0.624
ENSG00000272645 E042 4.0306497 0.413783813 0.4725439940 0.681912601 1 223962569 223962610 42 - 0.572 0.617 0.204
ENSG00000272645 E043 32.2288015 0.097345615 0.2465310988 0.484197844 1 223962611 223962708 98 - 1.528 1.378 -0.516
ENSG00000272645 E044 7.9144028 0.099273450 0.0412204733 0.157917585 1 223962709 223962749 41 - 1.108 0.758 -1.324
ENSG00000272645 E045 18.8381292 0.107033313 0.0263141156 0.116249371 1 223964327 223964455 129 - 1.402 1.121 -0.988
ENSG00000272645 E046 10.5616042 0.216304092 0.1605629387 0.377625922 1 223964456 223964461 6 - 1.111 0.912 -0.731
ENSG00000272645 E047 17.6370953 0.145744818 0.0775087087 0.239872998 1 223964462 223964539 78 - 1.355 1.102 -0.893
ENSG00000272645 E048 19.9591250 0.074800110 0.2859955286 0.526654652 1 223964586 223964703 118 - 1.309 1.184 -0.441
ENSG00000272645 E049 5.1205113 0.110490297 0.9847362920 0.994208682 1 223964704 223964709 6 - 0.646 0.692 0.193
ENSG00000272645 E050 4.6331280 0.083121806 0.8140703669 0.904684338 1 223964710 223964717 8 - 0.574 0.661 0.382
ENSG00000272645 E051 1.1707238 0.122568334 1.0000000000   1 223967182 223967283 102 - 0.228 0.282 0.406
ENSG00000272645 E052 18.8826215 0.014323684 0.2178361222 0.450847181 1 223971574 223971763 190 - 1.292 1.158 -0.472
ENSG00000272645 E053 29.2180092 0.094073940 0.0812943953 0.247417661 1 223973982 223974046 65 - 1.560 1.311 -0.861
ENSG00000272645 E054 32.4549834 0.094568308 0.2303840756 0.465535266 1 223976880 223977031 152 - 1.534 1.378 -0.540
ENSG00000272645 E055 17.2631443 0.002381359 0.4576302812 0.671523322 1 223977032 223977115 84 - 1.079 1.157 0.280
ENSG00000272645 E056 0.0000000       1 223982754 223982757 4 -      
ENSG00000272645 E057 19.7937540 0.014908345 0.5438743812 0.731832458 1 223982758 223982842 85 - 1.260 1.193 -0.239
ENSG00000272645 E058 53.4603479 0.015489625 0.5417175243 0.730313215 1 223982843 223983000 158 - 1.652 1.611 -0.140
ENSG00000272645 E059 40.4099791 0.018477981 0.7699043118 0.878583532 1 223983001 223983190 190 - 1.474 1.505 0.109
ENSG00000272645 E060 9.3139218 0.004264065 0.0033771095 0.025625226 1 223983191 223983193 3 - 1.169 0.820 -1.293
ENSG00000272645 E061 22.8420915 0.042039954 0.0068277271 0.043832651 1 223983194 223983264 71 - 1.504 1.190 -1.094
ENSG00000272645 E062 24.0804475 0.039894021 0.0028724651 0.022643580 1 223983265 223983285 21 - 1.541 1.206 -1.163
ENSG00000272645 E063 22.4071207 0.066582616 0.0167524753 0.084563077 1 223984382 223984440 59 - 1.497 1.183 -1.094
ENSG00000272645 E064 19.2945429 0.019748873 0.0306287959 0.129245674 1 223986575 223986638 64 - 1.387 1.149 -0.835
ENSG00000272645 E065 8.6778796 0.012261425 0.0071497449 0.045324242 1 223986639 223986640 2 - 1.148 0.808 -1.265
ENSG00000272645 E066 17.9421577 0.017018226 0.0005340557 0.005984490 1 223988045 223988154 110 - 1.434 1.081 -1.242
ENSG00000272645 E067 0.0000000       1 223992220 223992239 20 -      
ENSG00000272645 E068 2.9902466 0.271662306 0.3988565852 0.627303913 1 223992240 223992261 22 - 0.577 0.499 -0.364
ENSG00000272645 E069 3.3545841 0.345065780 0.1559245610 0.370784523 1 223992262 223992331 70 - 0.714 0.503 -0.934
ENSG00000272645 E070 15.5818996 0.097836467 0.0294664179 0.125771621 1 223992332 223992514 183 - 1.353 1.030 -1.149
ENSG00000272645 E071 25.0045273 0.064746837 0.0027428570 0.021820406 1 223992515 223992657 143 - 1.584 1.206 -1.312