ENSG00000269556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507237 ENSG00000269556 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM185A protein_coding protein_coding 25.33393 33.80319 14.22352 2.772961 0.1849475 -1.248293 2.433918 2.350787 1.903643 0.2062913 0.08615339 -0.302946 0.1033833 0.0700000 0.1337667 0.06376667 0.01678162 0.01678162 FALSE  
ENST00000600449 ENSG00000269556 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM185A protein_coding protein_coding 25.33393 33.80319 14.22352 2.772961 0.1849475 -1.248293 16.493374 22.238671 8.930566 2.1829296 0.51625522 -1.315281 0.6476333 0.6561333 0.6272333 -0.02890000 0.88286184 0.01678162 FALSE  
ENST00000611119 ENSG00000269556 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM185A protein_coding protein_coding 25.33393 33.80319 14.22352 2.772961 0.1849475 -1.248293 3.319391 5.181733 1.345601 0.5040626 0.41280186 -1.937283 0.1216708 0.1529000 0.0954000 -0.05750000 0.53779486 0.01678162 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000269556 E001 0.3751086 0.0250541754 0.6707768258   X 149596556 149596556 1 - 0.000 0.141 8.446
ENSG00000269556 E002 242.3231600 0.0002282744 0.0003930196 0.004662831 X 149596557 149597964 1408 - 2.256 2.347 0.305
ENSG00000269556 E003 94.7015161 0.0032282161 0.6167567086 0.781550383 X 149597965 149598255 291 - 1.907 1.932 0.084
ENSG00000269556 E004 114.9339298 0.0015180447 0.9708337131 0.987244872 X 149599554 149599677 124 - 2.007 2.007 0.001
ENSG00000269556 E005 62.8182609 0.0008307268 0.7316713138 0.855282715 X 149600303 149600304 2 - 1.760 1.743 -0.055
ENSG00000269556 E006 157.1837559 0.0005689909 0.9656000415 0.984706088 X 149600305 149600479 175 - 2.138 2.140 0.008
ENSG00000269556 E007 10.5685678 0.0464462479 0.5755300309 0.754007610 X 149600480 149602220 1741 - 1.054 0.983 -0.261
ENSG00000269556 E008 18.9226400 0.0022955232 0.0399624520 0.154612099 X 149603709 149603986 278 - 1.357 1.182 -0.613
ENSG00000269556 E009 161.8507504 0.0004548992 0.0400953826 0.154960473 X 149603987 149604066 80 - 2.100 2.167 0.223
ENSG00000269556 E010 84.3247785 0.0041259243 0.0700924685 0.224981350 X 149604067 149604070 4 - 1.799 1.895 0.326
ENSG00000269556 E011 3.1471055 0.0653712229 0.9915231593 0.997530975 X 149605155 149605201 47 - 0.569 0.570 0.004
ENSG00000269556 E012 2.3906114 0.1634350765 0.1388481792 0.345752285 X 149606731 149606809 79 - 0.682 0.378 -1.457
ENSG00000269556 E013 1.1583601 0.3786774030 0.1851760058   X 149608454 149608626 173 - 0.502 0.201 -1.889
ENSG00000269556 E014 183.6577213 0.0002621895 0.4729601739 0.682132544 X 149608627 149608691 65 - 2.190 2.211 0.071
ENSG00000269556 E015 254.2668232 0.0003221045 0.2142109348 0.446612692 X 149608692 149608829 138 - 2.367 2.338 -0.098
ENSG00000269556 E016 117.3810037 0.0004585197 0.0145767088 0.076521188 X 149608830 149608834 5 - 2.073 1.986 -0.291
ENSG00000269556 E017 214.4202673 0.0002452896 0.0085034242 0.051620077 X 149611287 149611463 177 - 2.321 2.254 -0.225
ENSG00000269556 E018 129.5236621 0.0003501713 0.3673042973 0.601823081 X 149631543 149631912 370 - 2.079 2.049 -0.101