ENSG00000268043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000611443 ENSG00000268043 HEK293_OSMI2_6hA HEK293_TMG_6hB NBPF12 protein_coding protein_coding 7.713386 9.702546 7.107407 0.6370087 0.06450759 -0.4484977 0.5694409 0.6317160 0.6349255 0.04844507 0.31346782 0.007197634 0.07555833 0.06506667 0.08996667 0.0249 0.992833615 0.008590756 FALSE TRUE
MSTRG.2037.1 ENSG00000268043 HEK293_OSMI2_6hA HEK293_TMG_6hB NBPF12 protein_coding   7.713386 9.702546 7.107407 0.6370087 0.06450759 -0.4484977 0.4732197 0.3256692 0.8762130 0.06091926 0.24195141 1.400613207 0.06330417 0.03303333 0.12323333 0.0902 0.060214824 0.008590756 FALSE TRUE
MSTRG.2037.12 ENSG00000268043 HEK293_OSMI2_6hA HEK293_TMG_6hB NBPF12 protein_coding   7.713386 9.702546 7.107407 0.6370087 0.06450759 -0.4484977 0.3429692 0.1990101 0.5709817 0.13990632 0.07367484 1.474919686 0.04438333 0.01913333 0.08043333 0.0613 0.166471441 0.008590756 TRUE TRUE
MSTRG.2037.18 ENSG00000268043 HEK293_OSMI2_6hA HEK293_TMG_6hB NBPF12 protein_coding   7.713386 9.702546 7.107407 0.6370087 0.06450759 -0.4484977 5.3773443 7.4641286 4.0544679 0.25051645 0.13434090 -0.878838891 0.69404167 0.77253333 0.57023333 -0.2023 0.008590756 0.008590756 FALSE TRUE
MSTRG.2037.7 ENSG00000268043 HEK293_OSMI2_6hA HEK293_TMG_6hB NBPF12 protein_coding   7.713386 9.702546 7.107407 0.6370087 0.06450759 -0.4484977 0.4212134 0.4275321 0.3771244 0.21389695 0.08981478 -0.176591655 0.05172500 0.04196667 0.05286667 0.0109 0.893249393 0.008590756 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000268043 E001 10.9867960 0.2175526119 0.927911808 0.966004838 1 146938611 146938743 133 + 1.108 1.054 -0.196
ENSG00000268043 E002 5.3067454 0.0858820639 0.234108004 0.469873346 1 146938744 146938794 51 + 0.900 0.716 -0.726
ENSG00000268043 E003 4.7811798 0.0746940067 0.243254122 0.480311425 1 146938795 146938808 14 + 0.858 0.690 -0.672
ENSG00000268043 E004 3.5063069 0.0872410259 0.270585691 0.510528773 1 146938809 146938815 7 + 0.759 0.578 -0.769
ENSG00000268043 E005 2.6657323 0.1850473225 0.477828159 0.685661570 1 146938816 146938819 4 + 0.663 0.503 -0.722
ENSG00000268043 E006 2.4933579 0.2537244969 0.436722413 0.656233224 1 146938820 146938821 2 + 0.661 0.460 -0.923
ENSG00000268043 E007 2.4933579 0.2537244969 0.436722413 0.656233224 1 146938822 146938825 4 + 0.661 0.460 -0.923
ENSG00000268043 E008 2.1893076 0.2963641575 0.681564368 0.823634139 1 146938826 146938838 13 + 0.586 0.459 -0.602
ENSG00000268043 E009 2.2010741 0.3015374951 0.538558552 0.728013667 1 146938839 146938864 26 + 0.623 0.420 -0.975
ENSG00000268043 E010 3.1950544 0.3079139140 0.920787726 0.962626254 1 146938865 146938982 118 + 0.689 0.577 -0.484
ENSG00000268043 E011 2.8321896 0.2634409966 0.745272288 0.863855790 1 146938983 146939012 30 + 0.658 0.519 -0.627
ENSG00000268043 E012 6.9042831 0.2381820060 0.665886398 0.813605046 1 146943291 146943562 272 + 0.992 0.817 -0.665
ENSG00000268043 E013 0.8737811 0.2763282454 0.397275922   1 146946555 146946558 4 + 0.388 0.192 -1.380
ENSG00000268043 E014 1.5939689 0.2705560510 0.207124074 0.438359836 1 146946559 146946607 49 + 0.587 0.260 -1.801
ENSG00000268043 E015 0.3503582 0.0281629937 0.744299318   1 146949314 146949323 10 + 0.137 0.107 -0.407
ENSG00000268043 E016 1.6340496 0.1242210724 0.275783506 0.515868238 1 146949324 146949391 68 + 0.511 0.326 -1.009
ENSG00000268043 E017 1.1522030 0.1510731684 0.390562357   1 146949392 146949422 31 + 0.398 0.265 -0.839
ENSG00000268043 E018 2.9206212 0.0176748472 0.792006258 0.891608190 1 146951108 146951275 168 + 0.599 0.609 0.044
ENSG00000268043 E019 1.1834906 0.2775260656 0.491602549   1 146951276 146951347 72 + 0.398 0.314 -0.501
ENSG00000268043 E020 2.4393948 0.0149087171 0.717367369 0.846504063 1 146951348 146951489 142 + 0.556 0.545 -0.050
ENSG00000268043 E021 2.3135838 0.0996540892 0.032586012 0.134922695 1 146951814 146952037 224 + 0.675 0.329 -1.721
ENSG00000268043 E022 1.0296370 0.0471320133 0.173834432   1 146959859 146959970 112 + 0.137 0.426 2.164
ENSG00000268043 E023 0.0000000       1 146959971 146960006 36 +      
ENSG00000268043 E024 3.1016551 0.0077170224 0.246700857 0.484396804 1 146960109 146960318 210 + 0.456 0.692 1.079
ENSG00000268043 E025 5.7269239 0.0056707671 0.273297411 0.513159372 1 146962161 146962263 103 + 0.864 0.781 -0.324
ENSG00000268043 E026 16.4264729 0.0026774095 0.004556642 0.032244737 1 146963095 146963309 215 + 1.331 1.159 -0.605
ENSG00000268043 E027 13.2586633 0.0121115146 0.004246796 0.030531016 1 146964357 146964429 73 + 1.267 1.043 -0.799
ENSG00000268043 E028 11.4321977 0.0238946607 0.091935701 0.267284931 1 146964893 146965104 212 + 1.157 1.035 -0.440
ENSG00000268043 E029 11.0732684 0.0029646598 0.079479011 0.243797554 1 146966464 146966673 210 + 1.134 1.023 -0.406
ENSG00000268043 E030 9.8162582 0.0132644162 0.077910518 0.240626215 1 146968448 146968550 103 + 1.108 0.962 -0.537
ENSG00000268043 E031 8.8654630 0.0036100347 0.018293973 0.090006009 1 146969382 146969596 215 + 1.097 0.903 -0.716
ENSG00000268043 E032 14.0699731 0.0028824615 0.004689496 0.032956104 1 146970647 146970719 73 + 1.275 1.087 -0.669
ENSG00000268043 E033 24.3209003 0.0024193285 0.000947709 0.009483959 1 146971183 146971394 212 + 1.487 1.320 -0.579
ENSG00000268043 E034 11.0796627 0.0033812072 0.198405646 0.427619388 1 146972751 146972960 210 + 1.110 1.045 -0.237
ENSG00000268043 E035 1.6494340 0.0188281601 0.496760912 0.698733533 1 146974739 146974790 52 + 0.456 0.380 -0.410
ENSG00000268043 E036 1.1847758 0.0164313621 0.345614569   1 146974791 146974841 51 + 0.396 0.265 -0.823
ENSG00000268043 E037 8.4194878 0.0649710562 0.232867041 0.468451172 1 146975677 146975891 215 + 1.012 0.926 -0.321
ENSG00000268043 E038 9.7171585 0.0381622238 0.088840885 0.261644827 1 146976929 146977001 73 + 1.098 0.952 -0.533
ENSG00000268043 E039 15.5878128 0.0162227815 0.231358382 0.466699641 1 146977466 146977671 206 + 1.239 1.188 -0.178
ENSG00000268043 E040 6.6202219 0.0047557576 0.555230365 0.739942606 1 146978959 146979010 52 + 0.886 0.872 -0.052
ENSG00000268043 E041 6.8335703 0.0348283296 0.074585692 0.233955781 1 146982928 146982980 53 + 0.981 0.801 -0.688
ENSG00000268043 E042 5.4702632 0.0480014871 0.091695349 0.266847761 1 146982981 146983011 31 + 0.908 0.715 -0.763
ENSG00000268043 E043 6.1743762 0.1979280270 0.218422053 0.451523271 1 146983012 146983091 80 + 0.971 0.735 -0.913
ENSG00000268043 E044 5.6135628 0.1269770716 0.133697820 0.337610256 1 146984134 146984185 52 + 0.911 0.720 -0.751
ENSG00000268043 E045 17.0428029 0.0522893479 0.558767768 0.742390557 1 146984813 146984985 173 + 1.231 1.263 0.111
ENSG00000268043 E046 29.7336139 0.0494216549 0.757095833 0.870918689 1 146985705 146985756 52 + 1.447 1.501 0.186
ENSG00000268043 E047 25.2601661 0.0517854203 0.431979372 0.652739020 1 146986352 146986524 173 + 1.418 1.404 -0.047
ENSG00000268043 E048 1.4462518 0.0125962362 0.063960138 0.211592754 1 146987234 146987285 52 + 0.137 0.511 2.593
ENSG00000268043 E049 10.0064584 0.0032248613 0.347350109 0.584842421 1 146987954 146988126 173 + 0.944 1.106 0.593
ENSG00000268043 E050 59.8856570 0.0006705666 0.027283453 0.119131959 1 146988841 146988949 109 + 1.676 1.845 0.570
ENSG00000268043 E051 160.9372363 0.0027814427 0.366296953 0.600946696 1 146989574 146989746 173 + 2.144 2.244 0.336
ENSG00000268043 E052 53.1489113 0.0101557946 0.367485775 0.601989581 1 146990466 146990517 52 + 1.655 1.779 0.420
ENSG00000268043 E053 31.5047878 0.0369324727 0.246028470 0.483669346 1 146991113 146991285 173 + 1.388 1.581 0.664
ENSG00000268043 E054 3.3609385 0.1924060796 0.381417261 0.613413736 1 146991995 146992046 52 + 0.461 0.742 1.258
ENSG00000268043 E055 2.8332118 0.0103826448 0.326382400 0.565571743 1 146992712 146992884 173 + 0.456 0.666 0.971
ENSG00000268043 E056 0.6120945 0.0198826567 0.561817682   1 146993599 146993707 109 + 0.137 0.265 1.174
ENSG00000268043 E057 170.9360099 1.2333505806 0.308199825 0.548827168 1 146994332 146996202 1871 + 1.983 2.351 1.230