ENSG00000267248

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586143 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA retained_intron 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.15666651 0.02229290 0.18771102 0.02229290 0.15208699 2.61410414 0.09532500 0.01106667 0.11956667 0.10850000 0.63011777 0.01621711   FALSE
ENST00000590744 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.08753180 0.10793546 0.02175706 0.10793546 0.02175706 -1.89284825 0.05537500 0.05363333 0.01356667 -0.04006667 1.00000000 0.01621711   FALSE
ENST00000658811 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.34431559 0.60908515 0.04544098 0.08189164 0.04544098 -3.48111312 0.20056667 0.29066667 0.03313333 -0.25753333 0.05352980 0.01621711   FALSE
ENST00000659112 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.16602872 0.11718262 0.11874682 0.04038604 0.02204880 0.01763522 0.10605000 0.05756667 0.08293333 0.02536667 0.88476431 0.01621711   FALSE
ENST00000661874 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.02749110 0.00000000 0.14638912 0.00000000 0.14638912 3.96706824 0.01770000 0.00000000 0.10366667 0.10366667 0.83308550 0.01621711   FALSE
ENST00000662447 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.08486295 0.08087152 0.18727910 0.08087152 0.18727910 1.11833796 0.05232917 0.04013333 0.11666667 0.07653333 0.98185955 0.01621711   FALSE
ENST00000663798 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.05633201 0.19449875 0.05576752 0.03889069 0.05576752 -1.63664484 0.03166250 0.09250000 0.03473333 -0.05776667 0.57982101 0.01621711   FALSE
ENST00000667343 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.18374996 0.19153231 0.34085085 0.11056450 0.20586848 0.79984668 0.11890417 0.09210000 0.24636667 0.15426667 0.88960544 0.01621711   FALSE
ENST00000668564 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.07326511 0.23192973 0.00000000 0.07103918 0.00000000 -4.59651615 0.04209583 0.11033333 0.00000000 -0.11033333 0.01621711 0.01621711   FALSE
ENST00000670169 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.20266404 0.21654273 0.25035961 0.14281531 0.13030343 0.20072247 0.12194583 0.10750000 0.17950000 0.07200000 0.93986338 0.01621711   FALSE
ENST00000686977 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.10156414 0.07884779 0.02628891 0.04701149 0.02628891 -1.29180728 0.06252917 0.03796667 0.01860000 -0.01936667 0.85079097 0.01621711   FALSE
ENST00000688989 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.03343326 0.00000000 0.08241530 0.00000000 0.08241530 3.20813179 0.02195000 0.00000000 0.05133333 0.05133333 0.78304161 0.01621711   FALSE
ENST00000692235 ENSG00000267248 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 1.63885 2.085272 1.463006 0.07168652 0.07217821 -0.5083742 0.03313919 0.20768932 0.00000000 0.20768932 0.00000000 -4.44419869 0.01635417 0.09320000 0.00000000 -0.09320000 0.93215959 0.01621711   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000267248 E001 0.0000000       17 60122642 60122651 10 -      
ENSG00000267248 E002 0.4702677 0.024376962 0.249512521   17 60122652 60123568 917 - 0.272 0.093 -1.864
ENSG00000267248 E003 0.0000000       17 60126478 60126526 49 -      
ENSG00000267248 E004 0.0000000       17 60126527 60126529 3 -      
ENSG00000267248 E005 0.0000000       17 60126530 60126530 1 -      
ENSG00000267248 E006 0.0000000       17 60126531 60126532 2 -      
ENSG00000267248 E007 0.0000000       17 60126533 60126534 2 -      
ENSG00000267248 E008 0.0000000       17 60126535 60126538 4 -      
ENSG00000267248 E009 0.0000000       17 60126539 60126539 1 -      
ENSG00000267248 E010 0.0000000       17 60126540 60126541 2 -      
ENSG00000267248 E011 0.0000000       17 60126542 60126548 7 -      
ENSG00000267248 E012 0.3206185 0.027082427 0.073662060   17 60126549 60126558 10 - 0.272 0.000 -10.816
ENSG00000267248 E013 1.1591001 0.086026205 0.812324546   17 60126559 60126604 46 - 0.362 0.337 -0.146
ENSG00000267248 E014 1.9691272 0.010998388 0.728558382 0.85335318 17 60126605 60126624 20 - 0.501 0.464 -0.184
ENSG00000267248 E015 11.9361433 0.003204725 0.787602462 0.88913896 17 60126625 60126865 241 - 1.058 1.113 0.200
ENSG00000267248 E016 1.6178413 0.012854472 0.694873957 0.83222080 17 60128402 60128535 134 - 0.437 0.387 -0.272
ENSG00000267248 E017 0.8569551 0.019752707 0.779030488   17 60128536 60128540 5 - 0.272 0.235 -0.272
ENSG00000267248 E018 2.9312724 0.010924385 0.361281895 0.59675309 17 60128541 60128659 119 - 0.651 0.531 -0.537
ENSG00000267248 E019 2.2862635 0.011998926 0.018175592 0.08959749 17 60128956 60128992 37 - 0.157 0.614 2.842
ENSG00000267248 E020 3.6435858 0.012255504 0.007086345 0.04501644 17 60128993 60129090 98 - 0.271 0.763 2.466
ENSG00000267248 E021 2.7646225 0.076300820 0.331113879 0.56998522 17 60130794 60130951 158 - 0.650 0.501 -0.678
ENSG00000267248 E022 3.2856237 0.160631734 0.406006788 0.63306178 17 60132056 60132435 380 - 0.695 0.562 -0.580
ENSG00000267248 E023 8.4869513 0.003658377 0.629317000 0.79004884 17 60132436 60132512 77 - 0.900 0.984 0.312
ENSG00000267248 E024 1.0539778 0.016777136 0.046059171   17 60134622 60134755 134 - 0.501 0.170 -2.180
ENSG00000267248 E025 13.8394594 0.003034729 0.091336743 0.26614686 17 60134756 60134841 86 - 1.221 1.105 -0.414
ENSG00000267248 E026 6.5998997 0.023675964 0.051206753 0.18259495 17 60134842 60134851 10 - 0.988 0.763 -0.865
ENSG00000267248 E027 5.6060916 0.010432684 0.218642274 0.45177605 17 60134852 60134853 2 - 0.877 0.744 -0.521
ENSG00000267248 E028 6.7026054 0.005897264 0.482775725 0.68893837 17 60134854 60134869 16 - 0.901 0.844 -0.217
ENSG00000267248 E029 13.7173165 0.002847477 0.802008516 0.89752589 17 60134870 60135085 216 - 1.119 1.172 0.190
ENSG00000267248 E030 3.6530145 0.007625809 0.004709944 0.03306064 17 60135086 60135096 11 - 0.272 0.780 2.533
ENSG00000267248 E031 21.7718839 0.286596332 0.158229448 0.37410756 17 60135097 60135743 647 - 1.151 1.414 0.924