ENSG00000266865

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000578883 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.06676421 0.00000000 0.38471281 0.000000000 0.20856167 5.30273142 0.02037500 0.0000 0.10800000 0.108000000 4.177900e-01 1.783494e-08   FALSE
ENST00000580190 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.17604339 0.00000000 0.90378280 0.000000000 0.09492051 6.51377939 0.05633750 0.0000 0.25933333 0.259333333 1.783494e-08 1.783494e-08 FALSE TRUE
ENST00000687724 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.41806804 0.43103351 0.30879206 0.043734875 0.04724339 -0.46827259 0.18362500 0.2548 0.08950000 -0.165300000 2.392779e-02 1.783494e-08 TRUE FALSE
ENST00000690641 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.23391626 0.21467696 0.42984322 0.072394427 0.06405260 0.96913719 0.09791667 0.1286 0.12303333 -0.005566667 9.983741e-01 1.783494e-08 TRUE FALSE
ENST00000691618 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.16752858 0.00000000 0.12665097 0.000000000 0.09891589 3.77242384 0.07522083 0.0000 0.03580000 0.035800000 6.134799e-01 1.783494e-08 TRUE FALSE
MSTRG.14097.10 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.57961774 0.61870973 0.52469347 0.054604203 0.14847122 -0.23368204 0.25203750 0.3664 0.15440000 -0.212000000 1.455836e-01 1.783494e-08   FALSE
MSTRG.14097.14 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.14751664 0.02965539 0.05468311 0.016501484 0.05468311 0.70587202 0.06417500 0.0174 0.01553333 -0.001866667 9.385272e-01 1.783494e-08 TRUE FALSE
MSTRG.14097.3 ENSG00000266865 HEK293_OSMI2_6hA HEK293_TMG_6hB transcribed_unprocessed_pseudogene   2.359429 1.686351 3.468827 0.03823017 0.1126692 1.036166 0.27921151 0.27307315 0.29009321 0.007041444 0.15183826 0.08423577 0.12128333 0.1619 0.08536667 -0.076533333 7.286842e-01 1.783494e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000266865 E001 0.0000000       17 31007813 31007944 132 +      
ENSG00000266865 E002 0.1779838 0.030994522 0.57734543   17 31007945 31008069 125 + 0.112 0.000 -9.138
ENSG00000266865 E003 4.2495044 0.006789059 0.94640571 0.97552675 17 31008070 31008496 427 + 0.710 0.719 0.038
ENSG00000266865 E004 2.9904485 0.053262695 0.71626631 0.84578073 17 31008497 31008534 38 + 0.564 0.622 0.258
ENSG00000266865 E005 2.9656981 0.019710569 0.94156677 0.97301058 17 31008535 31008571 37 + 0.597 0.583 -0.065
ENSG00000266865 E006 2.3645623 0.012212969 0.85439181 0.92726330 17 31008572 31008575 4 + 0.526 0.494 -0.153
ENSG00000266865 E007 2.5071969 0.010074947 0.67952139 0.82242728 17 31008576 31008578 3 + 0.563 0.494 -0.323
ENSG00000266865 E008 3.1442294 0.008285463 0.86783605 0.93478109 17 31008579 31008604 26 + 0.596 0.621 0.110
ENSG00000266865 E009 5.3175797 0.005789078 0.86833069 0.93504322 17 31008605 31008641 37 + 0.779 0.799 0.080
ENSG00000266865 E010 6.2708910 0.008551731 0.09544273 0.27377154 17 31008642 31008662 21 + 0.734 0.945 0.819
ENSG00000266865 E011 6.5855401 0.006269602 0.29849805 0.53893575 17 31008663 31008673 11 + 0.800 0.926 0.486
ENSG00000266865 E012 9.5836345 0.057639308 0.68290327 0.82450114 17 31008674 31008753 80 + 0.986 1.034 0.175
ENSG00000266865 E013 11.2810622 0.011050029 0.76784719 0.87733144 17 31008754 31008803 50 + 1.088 1.054 -0.123
ENSG00000266865 E014 0.0000000       17 31012921 31012956 36 +      
ENSG00000266865 E015 1.3332076 0.014130919 0.04784177   17 31016895 31017003 109 + 0.486 0.131 -2.547
ENSG00000266865 E016 2.3019895 0.010254571 0.38963664 0.62019518 17 31021049 31021162 114 + 0.442 0.583 0.679
ENSG00000266865 E017 19.4979906 0.002071245 0.22225747 0.45617747 17 31021910 31022042 133 + 1.347 1.254 -0.324
ENSG00000266865 E018 11.5024907 0.072345398 0.43681842 0.65630780 17 31022043 31023605 1563 + 1.136 1.049 -0.315
ENSG00000266865 E019 5.4399599 0.005458594 0.61514146 0.78036732 17 31023606 31023631 26 + 0.839 0.774 -0.254
ENSG00000266865 E020 10.6597917 0.003609738 0.89155369 0.94742050 17 31023632 31023760 129 + 1.065 1.051 -0.050
ENSG00000266865 E021 9.6054179 0.036760783 0.38725315 0.61833140 17 31023761 31024340 580 + 1.066 0.962 -0.382
ENSG00000266865 E022 2.2131954 0.010044396 0.84247434 0.92087356 17 31024341 31024376 36 + 0.526 0.494 -0.156
ENSG00000266865 E023 18.5785875 0.013090106 0.79476783 0.89320717 17 31024377 31024426 50 + 1.305 1.284 -0.075
ENSG00000266865 E024 0.2922838 0.027777663 0.89626655   17 31029389 31029471 83 + 0.112 0.131 0.258
ENSG00000266865 E025 6.0236477 0.008340978 0.07401176 0.23280111 17 31031560 31031682 123 + 0.734 0.959 0.874
ENSG00000266865 E026 0.5283420 0.136322464 0.71682063   17 31031881 31031946 66 + 0.203 0.132 -0.747
ENSG00000266865 E027 12.8622510 0.028969062 0.05446167 0.19016652 17 31032426 31032506 81 + 1.029 1.257 0.815
ENSG00000266865 E028 5.1930114 0.006079239 0.37317113 0.60666119 17 31033295 31033365 71 + 0.839 0.719 -0.476
ENSG00000266865 E029 16.4451808 0.041478979 0.42661283 0.64850680 17 31033924 31034285 362 + 1.197 1.291 0.331
ENSG00000266865 E030 28.3344266 0.003011911 0.59141476 0.76466606 17 31034286 31035654 1369 + 1.476 1.439 -0.129
ENSG00000266865 E031 0.1426347 0.033572667 0.57632057   17 31045407 31045409 3 + 0.112 0.000 -11.219
ENSG00000266865 E032 1.6206897 0.026604459 0.01780264 0.08836693 17 31045410 31045549 140 + 0.563 0.131 -2.909
ENSG00000266865 E033 0.1779838 0.030994522 0.57734543   17 31045550 31045937 388 + 0.112 0.000 -11.223
ENSG00000266865 E034 0.9662812 0.101602647 0.02186555   17 31071912 31072049 138 + 0.443 0.000 -13.431
ENSG00000266865 E035 0.1308682 0.031135384 0.40975058   17 31091604 31091707 104 + 0.000 0.131 11.028
ENSG00000266865 E036 0.1426347 0.033572667 0.57632057   17 31092876 31093127 252 + 0.112 0.000 -11.219