ENSG00000262919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440428 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding protein_coding 97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 11.623958 19.014364 5.345354 1.335886 2.92112708 -1.8287945 0.13766250 0.1490000 0.12550000 -0.02350000 9.126593e-01 5.115607e-45 FALSE TRUE
ENST00000576892 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding protein_coding 97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 52.671762 78.780998 16.820798 16.301223 0.43898736 -2.2269272 0.52097083 0.5746000 0.41726667 -0.15733333 5.944153e-03 5.115607e-45 FALSE TRUE
ENST00000620088 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding nonsense_mediated_decay 97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 13.768066 19.542108 4.708390 4.107340 2.47482716 -2.0509576 0.12407083 0.1422667 0.12173333 -0.02053333 9.121370e-01 5.115607e-45 FALSE TRUE
MSTRG.35066.3 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding   97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 4.033117 4.465364 3.857584 2.304633 0.07656731 -0.2105725 0.04383333 0.0278000 0.09583333 0.06803333 6.322094e-01 5.115607e-45 FALSE TRUE
MSTRG.35066.7 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding   97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 2.697918 0.000000 7.236130 0.000000 0.97391655 9.5010668 0.04384583 0.0000000 0.17700000 0.17700000 5.115607e-45 5.115607e-45 FALSE TRUE
MSTRG.35066.9 ENSG00000262919 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNQ protein_coding   97.13338 136.3876 40.52112 26.94613 2.119566 -1.750716 6.229092 8.600927 0.000000 5.072878 0.00000000 -9.7500248 0.04862917 0.0519000 0.00000000 -0.05190000 3.950820e-01 5.115607e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000262919 E001 9.2648205 0.0044442350 5.920087e-04 0.0065084933 X 153587925 153587926 2 - 0.367 0.976 2.668
ENSG00000262919 E002 9.6997389 0.0038327807 8.086965e-03 0.0497257218 X 153587927 153587928 2 - 0.564 0.983 1.694
ENSG00000262919 E003 18.9618458 0.0018096833 2.031304e-02 0.0969811897 X 153587929 153587931 3 - 0.984 1.241 0.924
ENSG00000262919 E004 183.4721005 0.0008094164 9.298993e-02 0.2692924660 X 153587932 153587998 67 - 2.209 2.149 -0.201
ENSG00000262919 E005 230.4452389 0.0007877734 1.062309e-03 0.0103889683 X 153587999 153588028 30 - 2.341 2.238 -0.343
ENSG00000262919 E006 268.7667335 0.0012322712 9.897864e-04 0.0098339163 X 153588029 153588054 26 - 2.408 2.303 -0.349
ENSG00000262919 E007 351.5686810 0.0001984813 6.732737e-04 0.0072109838 X 153588055 153588097 43 - 2.507 2.428 -0.263
ENSG00000262919 E008 529.6721334 0.0001687517 4.212883e-01 0.6445851999 X 153588098 153588162 65 - 2.634 2.618 -0.051
ENSG00000262919 E009 1055.1232390 0.0001378233 9.963996e-01 0.9998911117 X 153588163 153588394 232 - 2.921 2.921 -0.001
ENSG00000262919 E010 344.5816797 0.0001665985 8.641493e-01 0.9327207948 X 153588395 153588454 60 - 2.433 2.437 0.014
ENSG00000262919 E011 542.4249755 0.0004007599 8.764826e-03 0.0527788490 X 153592506 153592574 69 - 2.587 2.642 0.183
ENSG00000262919 E012 380.8049923 0.0002630880 4.122454e-03 0.0298519295 X 153592575 153592611 37 - 2.422 2.491 0.231
ENSG00000262919 E013 588.0944161 0.0001281855 3.643679e-01 0.5993089020 X 153592612 153592703 92 - 2.654 2.670 0.055
ENSG00000262919 E014 420.7584942 0.0001422504 5.236911e-01 0.7175980544 X 153592704 153592733 30 - 2.511 2.525 0.046
ENSG00000262919 E015 747.8629706 0.0001286973 2.462277e-01 0.4838425776 X 153594547 153594679 133 - 2.786 2.766 -0.064
ENSG00000262919 E016 727.9634891 0.0013278799 6.761660e-01 0.8203034181 X 153596004 153596187 184 - 2.766 2.754 -0.039
ENSG00000262919 E017 10.5951579 0.0898338181 1.249265e-02 0.0684085968 X 153597422 153597706 285 - 1.284 0.836 -1.638
ENSG00000262919 E018 9.2337903 0.0130187216 3.963599e-01 0.6254101869 X 153598291 153598356 66 - 1.013 0.896 -0.438
ENSG00000262919 E019 180.0582559 0.0002572774 7.226940e-02 0.2293431703 X 153598962 153598965 4 - 2.105 2.167 0.208
ENSG00000262919 E020 317.4757318 0.0010937697 4.466064e-05 0.0007559458 X 153598966 153599179 214 - 2.294 2.420 0.421
ENSG00000262919 E021 0.3032425 0.0274424043 1.000000e+00   X 153599907 153600045 139 - 0.001 0.118 7.872