ENSG00000261236

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000569669 ENSG00000261236 HEK293_OSMI2_6hA HEK293_TMG_6hB BOP1 protein_coding protein_coding 131.3365 211.0206 55.40184 38.97805 2.092302 -1.929186 123.873035 200.616592 48.903465 38.4644029 2.24388823 -2.0362093 0.92734583 0.9474667 0.8822 -0.06526667 2.713183e-02 8.789391e-11 FALSE  
MSTRG.32250.1 ENSG00000261236 HEK293_OSMI2_6hA HEK293_TMG_6hB BOP1 protein_coding   131.3365 211.0206 55.40184 38.97805 2.092302 -1.929186 4.361277 5.754497 4.814124 0.7787397 0.05326335 -0.2569276 0.04310417 0.0279000 0.0871 0.05920000 8.789391e-11 8.789391e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000261236 E001 47.208060 6.264573e-02 1.935883e-04 2.605051e-03 8 144261983 144262044 62 - 1.928 1.427 -1.702
ENSG00000261236 E002 1031.773247 1.555348e-04 7.561784e-07 2.228292e-05 8 144262045 144262317 273 - 2.950 2.884 -0.222
ENSG00000261236 E003 1142.280344 2.481335e-04 2.055148e-02 9.786373e-02 8 144262396 144262503 108 - 2.964 2.934 -0.098
ENSG00000261236 E004 658.391495 1.605788e-04 8.650716e-01 9.332003e-01 8 144262588 144262615 28 - 2.698 2.702 0.014
ENSG00000261236 E005 721.116628 1.032212e-04 9.477338e-01 9.761862e-01 8 144262616 144262672 57 - 2.736 2.743 0.021
ENSG00000261236 E006 3.303582 3.763363e-02 7.863099e-01 8.882987e-01 8 144262673 144262788 116 - 0.494 0.546 0.250
ENSG00000261236 E007 1625.098309 7.014518e-04 4.346354e-06 1.019490e-04 8 144262853 144263141 289 - 3.021 3.102 0.270
ENSG00000261236 E008 3.950407 1.140987e-01 8.741236e-02 2.590053e-01 8 144263142 144263220 79 - 0.232 0.660 2.337
ENSG00000261236 E009 1187.668440 3.676840e-03 1.106682e-03 1.071800e-02 8 144263221 144263401 181 - 2.861 2.968 0.358
ENSG00000261236 E010 30.351667 5.093542e-02 4.224836e-02 1.605519e-01 8 144263402 144263477 76 - 1.588 1.315 -0.941
ENSG00000261236 E011 1165.253862 8.527447e-04 3.650804e-02 1.456197e-01 8 144263478 144263610 133 - 2.907 2.952 0.152
ENSG00000261236 E012 988.315570 8.885578e-05 9.343379e-02 2.700885e-01 8 144263692 144263761 70 - 2.850 2.882 0.108
ENSG00000261236 E013 1103.738222 7.370706e-05 1.051306e-01 2.908746e-01 8 144263831 144263911 81 - 2.901 2.931 0.101
ENSG00000261236 E014 1445.797364 3.780733e-04 3.472313e-02 1.408591e-01 8 144263981 144264142 162 - 3.009 3.045 0.119
ENSG00000261236 E015 1137.851798 2.267033e-04 3.567121e-01 5.931056e-01 8 144264225 144264341 117 - 2.920 2.939 0.063
ENSG00000261236 E016 921.473179 1.959311e-04 7.085765e-01 8.408810e-01 8 144264342 144264437 96 - 2.845 2.845 0.000
ENSG00000261236 E017 565.643860 1.296237e-04 3.562694e-01 5.927632e-01 8 144264515 144264543 29 - 2.644 2.633 -0.037
ENSG00000261236 E018 783.999233 1.000572e-04 7.887804e-01 8.897756e-01 8 144264544 144264616 73 - 2.774 2.777 0.009
ENSG00000261236 E019 1005.827514 2.001136e-04 5.562870e-01 7.407124e-01 8 144264714 144264831 118 - 2.872 2.886 0.048
ENSG00000261236 E020 676.601702 2.136397e-03 1.772769e-01 4.001448e-01 8 144264917 144264933 17 - 2.741 2.702 -0.128
ENSG00000261236 E021 1106.493223 1.606572e-04 1.105213e-02 6.258647e-02 8 144264934 144265071 138 - 2.952 2.920 -0.104
ENSG00000261236 E022 5.872464 2.155799e-01 7.936216e-01 8.924505e-01 8 144265072 144265459 388 - 0.768 0.723 -0.181
ENSG00000261236 E023 6.990915 7.765493e-02 6.407097e-01 7.973856e-01 8 144265583 144266086 504 - 0.866 0.780 -0.336
ENSG00000261236 E024 1002.141956 4.683958e-04 3.941032e-05 6.795746e-04 8 144276224 144276304 81 - 2.936 2.869 -0.225
ENSG00000261236 E025 1.958766 4.341921e-02 9.033030e-01 9.535338e-01 8 144281684 144281933 250 - 0.382 0.416 0.188
ENSG00000261236 E026 1257.382087 1.012215e-04 5.635555e-06 1.279474e-04 8 144289095 144289304 210 - 3.025 2.973 -0.175
ENSG00000261236 E027 431.784701 8.860382e-04 6.472120e-01 8.016007e-01 8 144291272 144291438 167 - 2.502 2.520 0.063