ENSG00000259803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562855 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding protein_coding 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 1.1805196 1.2327548 0.41713079 0.09809608 0.15954572 -1.5407919 0.28636250 0.27370000 0.16026667 -0.11343333 0.614248372 0.001689306 FALSE TRUE
ENST00000562916 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding retained_intron 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.9211509 1.1821147 0.90808210 0.65189879 0.14341689 -0.3768280 0.21578750 0.20293333 0.37403333 0.17110000 0.759998411 0.001689306 FALSE FALSE
ENST00000563595 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding retained_intron 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.1700322 0.1679122 0.00000000 0.16791223 0.00000000 -4.1530938 0.05012083 0.05496667 0.00000000 -0.05496667 0.982157085 0.001689306 FALSE FALSE
ENST00000568161 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding retained_intron 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.1426592 0.0000000 0.31549968 0.00000000 0.19370290 5.0245842 0.04884167 0.00000000 0.14220000 0.14220000 0.249807983 0.001689306   FALSE
ENST00000603735 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding retained_intron 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.4160704 0.3618602 0.29173142 0.20886003 0.29173142 -0.3014954 0.09184583 0.06510000 0.10936667 0.04426667 0.800642252 0.001689306   FALSE
ENST00000614943 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding protein_coding 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.6995584 0.7991452 0.20934509 0.24032175 0.20934509 -1.8831963 0.15165000 0.15856667 0.07566667 -0.08290000 0.500331897 0.001689306 FALSE TRUE
ENST00000682282 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding protein_coding 4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.2663995 0.3087367 0.22547170 0.16158990 0.13502679 -0.4368116 0.06028750 0.06760000 0.09240000 0.02480000 0.974254683 0.001689306 FALSE TRUE
MSTRG.13251.6 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding   4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.1644884 0.5230550 0.00000000 0.12283767 0.00000000 -5.7362126 0.03545000 0.12020000 0.00000000 -0.12020000 0.001689306 0.001689306 FALSE FALSE
MSTRG.13251.7 ENSG00000259803 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A31 protein_coding   4.232266 4.853052 2.49476 1.142066 0.2244457 -0.9571895 0.2605749 0.2774729 0.09023958 0.19964054 0.09023958 -1.5199738 0.05694583 0.05690000 0.03260000 -0.02430000 0.899126878 0.001689306 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000259803 E001 26.8428434 0.001377230 0.080996414 0.24679968 16 89195761 89196148 388 - 1.240 1.386 0.510
ENSG00000259803 E002 9.2834509 0.003594865 0.388445259 0.61920439 16 89196149 89196150 2 - 0.824 0.951 0.487
ENSG00000259803 E003 15.3135636 0.003206131 0.088422410 0.26086024 16 89196151 89196305 155 - 0.963 1.158 0.711
ENSG00000259803 E004 0.1723744 5.199785661 0.686771703   16 89196347 89196386 40 - 0.001 0.069 7.028
ENSG00000259803 E005 14.0074484 0.033901422 0.466042203 0.67727808 16 89197298 89197409 112 - 1.167 1.064 -0.371
ENSG00000259803 E006 30.8104618 0.001629327 0.970122009 0.98690526 16 89198122 89198336 215 - 1.418 1.412 -0.020
ENSG00000259803 E007 29.4751016 0.005016435 0.667934364 0.81488683 16 89198442 89198550 109 - 1.361 1.402 0.140
ENSG00000259803 E008 30.7872819 0.001751147 0.662030548 0.81111041 16 89198652 89198797 146 - 1.448 1.414 -0.118
ENSG00000259803 E009 9.2699219 0.004152589 0.514115787 0.71105226 16 89198798 89198837 40 - 0.863 0.958 0.361
ENSG00000259803 E010 5.3683475 0.056956837 0.904410195 0.95416264 16 89198838 89198867 30 - 0.678 0.755 0.319
ENSG00000259803 E011 13.8194215 0.003251365 0.443038435 0.66076423 16 89199023 89199104 82 - 1.019 1.110 0.332
ENSG00000259803 E012 15.4941763 0.002564031 0.484757920 0.69035157 16 89199105 89199191 87 - 1.190 1.121 -0.244
ENSG00000259803 E013 6.6096247 0.208434479 1.000000000 1.00000000 16 89199412 89199412 1 - 0.725 0.817 0.367
ENSG00000259803 E014 25.1364709 0.001503058 0.485978411 0.69122022 16 89199413 89199567 155 - 1.284 1.342 0.202
ENSG00000259803 E015 7.2217370 0.074896923 0.627097532 0.78860499 16 89199568 89199655 88 - 0.859 0.833 -0.100
ENSG00000259803 E016 15.3058676 0.002546797 0.348579804 0.58602459 16 89199713 89199771 59 - 1.207 1.116 -0.325
ENSG00000259803 E017 12.1656026 0.045609426 0.902608729 0.95313175 16 89199772 89199816 45 - 1.062 1.043 -0.070
ENSG00000259803 E018 15.6765155 0.003251439 0.001943957 0.01669171 16 89199817 89200318 502 - 1.350 1.070 -0.993
ENSG00000259803 E019 5.2147629 0.635906075 0.720430590 0.84848300 16 89200473 89200477 5 - 0.714 0.723 0.037
ENSG00000259803 E020 14.9676436 0.039716492 0.233378142 0.46901610 16 89200478 89200695 218 - 1.220 1.095 -0.446
ENSG00000259803 E021 7.2535640 0.029037228 0.134747527 0.33929732 16 89201262 89201486 225 - 0.617 0.888 1.100
ENSG00000259803 E022 4.7167200 0.016616069 0.212498993 0.44464836 16 89201487 89201590 104 - 0.823 0.635 -0.773
ENSG00000259803 E023 4.0377487 0.007465237 0.175444431 0.39774408 16 89201591 89201666 76 - 0.781 0.581 -0.842