ENSG00000259673

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000670822 ENSG00000259673 HEK293_OSMI2_6hA HEK293_TMG_6hB IQCH-AS1 lncRNA lncRNA 5.89039 7.266321 2.593385 0.4248356 0.4328973 -1.48282 0.2153095 0.1391429 0.3100472 0.01190315 0.04618831 1.101589 0.05914167 0.0191000 0.12743333 0.10833333 0.00115471 0.00115471   FALSE
MSTRG.11099.10 ENSG00000259673 HEK293_OSMI2_6hA HEK293_TMG_6hB IQCH-AS1 lncRNA   5.89039 7.266321 2.593385 0.4248356 0.4328973 -1.48282 0.5918736 0.8947042 0.2294464 0.13936425 0.09390574 -1.917743 0.09224167 0.1219667 0.08383333 -0.03813333 0.74852519 0.00115471   FALSE
MSTRG.11099.11 ENSG00000259673 HEK293_OSMI2_6hA HEK293_TMG_6hB IQCH-AS1 lncRNA   5.89039 7.266321 2.593385 0.4248356 0.4328973 -1.48282 3.5676496 4.3944680 1.2650720 0.23476261 0.13324439 -1.788389 0.58733750 0.6096000 0.50280000 -0.10680000 0.72053428 0.00115471 FALSE FALSE
MSTRG.11099.12 ENSG00000259673 HEK293_OSMI2_6hA HEK293_TMG_6hB IQCH-AS1 lncRNA   5.89039 7.266321 2.593385 0.4248356 0.4328973 -1.48282 1.0378020 1.5311789 0.2893141 0.37473345 0.05320093 -2.364302 0.15725833 0.2061000 0.11573333 -0.09036667 0.55617385 0.00115471   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000259673 E001 0.0000000       15 67290636 67291044 409 -      
ENSG00000259673 E002 0.0000000       15 67403619 67403625 7 -      
ENSG00000259673 E003 18.3396965 0.0033793494 8.822809e-21 2.853935e-18 15 67403626 67406595 2970 - 1.661 0.912 -2.643
ENSG00000259673 E004 12.2966318 0.0061835342 6.357610e-24 2.894553e-21 15 67406596 67408076 1481 - 1.592 0.614 -3.612
ENSG00000259673 E005 4.0663820 0.0064992324 4.044198e-12 3.748897e-10 15 67408077 67408475 399 - 1.177 0.210 -4.493
ENSG00000259673 E006 0.3206185 0.0274424043 1.803976e-02   15 67413503 67413538 36 - 0.369 0.000 -13.935
ENSG00000259673 E007 1.2128502 0.3348867307 5.898732e-01   15 67418886 67421208 2323 - 0.369 0.257 -0.725
ENSG00000259673 E008 0.8397668 0.0177011425 1.000000e+00   15 67421209 67421334 126 - 0.222 0.210 -0.100
ENSG00000259673 E009 3.1041985 0.0486351568 1.919456e-02 9.313097e-02 15 67421335 67421498 164 - 0.845 0.431 -1.819
ENSG00000259673 E010 2.0822098 0.0223044356 2.308610e-03 1.910600e-02 15 67430321 67430400 80 - 0.802 0.286 -2.520
ENSG00000259673 E011 0.9991572 0.2816830810 1.440332e-01   15 67430401 67431837 1437 - 0.478 0.169 -2.079
ENSG00000259673 E012 0.3393995 0.0255780090 1.789372e-02   15 67454387 67454435 49 - 0.369 0.000 -13.949
ENSG00000259673 E013 5.2066627 0.0051781210 6.144455e-04 6.707144e-03 15 67459692 67459975 284 - 1.042 0.580 -1.840
ENSG00000259673 E014 1.1603853 0.0147267448 1.528157e-01   15 67466494 67466711 218 - 0.478 0.210 -1.686
ENSG00000259673 E015 0.3337900 0.0317556462 2.929271e-01   15 67466712 67466757 46 - 0.222 0.063 -2.101
ENSG00000259673 E016 0.0000000       15 67466962 67467054 93 -      
ENSG00000259673 E017 0.0000000       15 67514920 67514922 3 -      
ENSG00000259673 E018 57.9999014 0.0007430530 6.468067e-05 1.038404e-03 15 67514923 67515066 144 - 1.463 1.704 0.822
ENSG00000259673 E019 2.1567095 0.6297418475 2.798760e-01 5.199633e-01 15 67518386 67518999 614 - 0.642 0.356 -1.413
ENSG00000259673 E020 87.8816189 0.0005998298 1.437046e-07 5.139920e-06 15 67519000 67519102 103 - 1.634 1.883 0.841
ENSG00000259673 E021 3.8678203 0.1261815169 8.776282e-01 9.400577e-01 15 67519729 67519849 121 - 0.568 0.602 0.154
ENSG00000259673 E022 0.5059767 0.0217538133 6.574930e-01   15 67520006 67520101 96 - 0.000 0.167 10.070
ENSG00000259673 E023 0.0000000       15 67520192 67520265 74 -      
ENSG00000259673 E024 1.9762095 0.0118353593 3.065262e-03 2.380754e-02 15 67520779 67520988 210 - 0.754 0.250 -2.586
ENSG00000259673 E025 1.2260217 0.5626449904 9.437580e-01   15 67521005 67521062 58 - 0.223 0.297 0.553
ENSG00000259673 E026 15.8997004 0.0023210887 2.340783e-04 3.046822e-03 15 67521494 67521518 25 - 0.700 1.185 1.837
ENSG00000259673 E027 43.5227035 0.0437955306 2.811353e-04 3.540470e-03 15 67521519 67521545 27 - 1.154 1.598 1.542
ENSG00000259673 E028 71.4221836 0.0148389213 1.071562e-02 6.117564e-02 15 67521546 67523282 1737 - 1.594 1.783 0.640