ENSG00000259343

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000559277 ENSG00000259343 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.367873 3.774899 1.626179 0.2637359 0.1860077 -1.209924 1.12245175 1.23580393 0.66896992 0.05561715 0.02905740 -0.8756575 0.32894583 0.32863333 0.41953333 0.09090000 0.728632124 0.000995094   FALSE
ENST00000560973 ENSG00000259343 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.367873 3.774899 1.626179 0.2637359 0.1860077 -1.209924 0.02491578 0.00000000 0.12184184 0.00000000 0.04446886 3.7207364 0.01155000 0.00000000 0.07056667 0.07056667 0.000995094 0.000995094 FALSE FALSE
ENST00000669758 ENSG00000259343 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.367873 3.774899 1.626179 0.2637359 0.1860077 -1.209924 0.03565012 0.00000000 0.13204588 0.00000000 0.07804611 3.8282851 0.01758750 0.00000000 0.08980000 0.08980000 0.166319919 0.000995094   FALSE
ENST00000687585 ENSG00000259343 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.367873 3.774899 1.626179 0.2637359 0.1860077 -1.209924 1.58698291 2.10992284 0.48217271 0.30372867 0.24714039 -2.1067752 0.44543750 0.55280000 0.27000000 -0.28280000 0.626301327 0.000995094   FALSE
MSTRG.11366.4 ENSG00000259343 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   3.367873 3.774899 1.626179 0.2637359 0.1860077 -1.209924 0.16406944 0.07214749 0.03643634 0.04121632 0.03643634 -0.8229622 0.05490417 0.02056667 0.02276667 0.00220000 0.977009823 0.000995094   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000259343 E001 0.1426347 0.032649190 0.152274484   15 81324338 81324341 4 + 0.191 0.000 -12.174
ENSG00000259343 E002 0.1426347 0.032649190 0.152274484   15 81324342 81324342 1 + 0.191 0.000 -14.470
ENSG00000259343 E003 0.2735028 0.027442404 0.424781695   15 81324343 81324367 25 + 0.191 0.075 -1.562
ENSG00000259343 E004 0.2735028 0.027442404 0.424781695   15 81324368 81324376 9 + 0.191 0.075 -1.562
ENSG00000259343 E005 9.1864003 0.025093718 0.164399059 0.38325703 15 81324377 81324437 61 + 1.081 0.916 -0.611
ENSG00000259343 E006 9.4492341 0.005562072 0.276978519 0.51700161 15 81324438 81324443 6 + 1.062 0.939 -0.454
ENSG00000259343 E007 14.9863769 0.002351055 0.628348788 0.78949450 15 81324444 81324487 44 + 1.187 1.139 -0.174
ENSG00000259343 E008 15.3266137 0.002191583 0.953596053 0.97870735 15 81324488 81324508 21 + 1.155 1.157 0.005
ENSG00000259343 E009 13.6827892 0.002410563 0.662960831 0.81172312 15 81324509 81324509 1 + 1.082 1.121 0.141
ENSG00000259343 E010 13.7832975 0.002376281 0.619896404 0.78375696 15 81324510 81324513 4 + 1.082 1.127 0.163
ENSG00000259343 E011 19.0457200 0.002027536 0.796618133 0.89434235 15 81324514 81324561 48 + 1.232 1.249 0.059
ENSG00000259343 E012 0.0000000       15 81324568 81324812 245 +      
ENSG00000259343 E013 0.2922838 0.027632114 0.420800289   15 81331911 81332023 113 + 0.191 0.075 -1.563
ENSG00000259343 E014 12.8827906 0.066499093 0.233446080 0.46910478 15 81332345 81332346 2 + 0.985 1.118 0.485
ENSG00000259343 E015 26.2865738 0.001884373 0.063745686 0.21113008 15 81332347 81332455 109 + 1.272 1.409 0.476
ENSG00000259343 E016 20.0721899 0.045549753 0.131138328 0.33362752 15 81332456 81332541 86 + 1.146 1.301 0.547
ENSG00000259343 E017 0.1308682 0.033615294 1.000000000   15 81341150 81341219 70 + 0.000 0.075 11.155
ENSG00000259343 E018 26.8785116 0.014000506 0.567762639 0.74861794 15 81341562 81341708 147 + 1.352 1.404 0.181
ENSG00000259343 E019 3.6789007 0.008492497 0.123247899 0.32089918 15 81341709 81342732 1024 + 0.777 0.538 -1.025
ENSG00000259343 E020 30.7266165 0.001977524 0.377292951 0.61011736 15 81342733 81343379 647 + 1.395 1.454 0.205
ENSG00000259343 E021 1.7300004 0.143893385 0.002119534 0.01787041 15 81358336 81358503 168 + 0.775 0.139 -3.719
ENSG00000259343 E022 0.9534696 0.016766403 0.003523270   15 81361919 81362036 118 + 0.576 0.075 -3.878
ENSG00000259343 E023 0.1308682 0.033615294 1.000000000   15 81362037 81362937 901 + 0.000 0.075 11.155
ENSG00000259343 E024 0.8108349 0.019387492 0.012131873   15 81380209 81380254 46 + 0.507 0.075 -3.557
ENSG00000259343 E025 0.0000000       15 81380255 81380260 6 +      
ENSG00000259343 E026 0.8211734 0.301725394 0.501165117   15 81388105 81388864 760 + 0.322 0.197 -0.938
ENSG00000259343 E027 0.3040503 0.027442404 0.036004856   15 81388865 81388991 127 + 0.324 0.000 -15.369
ENSG00000259343 E028 1.3271501 0.054370945 1.000000000   15 81388992 81389899 908 + 0.324 0.329 0.035
ENSG00000259343 E029 2.8758882 0.024572922 0.376975779 0.60983404 15 81393078 81395536 2459 + 0.636 0.488 -0.681
ENSG00000259343 E030 1.9292814 0.174308248 0.050672142 0.18125696 15 81409115 81410015 901 + 0.688 0.289 -2.037
ENSG00000259343 E031 0.1723744 0.037995506 1.000000000   15 81410517 81410602 86 + 0.000 0.075 11.151
ENSG00000259343 E032 0.1723744 0.037995506 1.000000000   15 81410605 81410695 91 + 0.000 0.075 11.151
ENSG00000259343 E033 0.0000000       15 81410696 81410750 55 +      
ENSG00000259343 E034 0.3447487 0.484081555 1.000000000   15 81410751 81411267 517 + 0.000 0.141 11.671
ENSG00000259343 E035 0.1614157 0.037346877 0.150891928   15 81418984 81419182 199 + 0.191 0.000 -14.457
ENSG00000259343 E036 0.0000000       15 81419183 81420357 1175 +      
ENSG00000259343 E037 0.0000000       15 81422749 81423883 1135 +      
ENSG00000259343 E038 0.1426347 0.032649190 0.152274484   15 81442905 81443291 387 + 0.191 0.000 -14.470
ENSG00000259343 E039 0.1308682 0.033615294 1.000000000   15 81516503 81518200 1698 + 0.000 0.075 11.155