ENSG00000259129

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000555985 ENSG00000259129 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC00648 lncRNA lncRNA 2.518752 2.040471 2.1368 0.1806487 0.5706827 0.06623261 0.4861565 0.27764243 0.4715117 0.05471625 0.0985281 0.7432944 0.21110000 0.13350000 0.28893333 0.15543333 0.74155446 0.03297623   FALSE
MSTRG.9470.1 ENSG00000259129 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC00648 lncRNA   2.518752 2.040471 2.1368 0.1806487 0.5706827 0.06623261 0.2138637 0.17471841 0.5656093 0.09394996 0.2002270 1.6397624 0.08539583 0.09500000 0.25046667 0.15546667 0.56268173 0.03297623   FALSE
MSTRG.9470.2 ENSG00000259129 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC00648 lncRNA   2.518752 2.040471 2.1368 0.1806487 0.5706827 0.06623261 0.5162258 0.06321302 0.6343302 0.06321302 0.2230417 3.1376281 0.21128333 0.02663333 0.29173333 0.26510000 0.03297623 0.03297623   FALSE
MSTRG.9470.5 ENSG00000259129 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC00648 lncRNA   2.518752 2.040471 2.1368 0.1806487 0.5706827 0.06623261 0.1124705 0.00000000 0.1504100 0.00000000 0.1504100 4.0036919 0.03507500 0.00000000 0.06156667 0.06156667 0.83598567 0.03297623   FALSE
MSTRG.9470.9 ENSG00000259129 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC00648 lncRNA   2.518752 2.040471 2.1368 0.1806487 0.5706827 0.06623261 1.0060199 1.48817261 0.2685692 0.13149987 0.2685692 -2.4270961 0.39447500 0.72940000 0.09146667 -0.63793333 0.03932475 0.03297623   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000259129 E001 1.0657443 0.165868344 0.14687827   14 47715466 47715468 3 - 0.432 0.134 -2.233
ENSG00000259129 E002 3.3102950 0.010430943 0.01206915 0.0667237 14 47715469 47715607 139 - 0.771 0.388 -1.763
ENSG00000259129 E003 18.4927463 0.097912041 0.33589876 0.5743215 14 47764954 47766685 1732 - 1.329 1.234 -0.334
ENSG00000259129 E004 3.6396954 0.011166652 0.20073770 0.4306529 14 47766686 47766811 126 - 0.727 0.547 -0.779
ENSG00000259129 E005 4.2009701 0.038044034 0.67004851 0.8163343 14 47766812 47766927 116 - 0.728 0.666 -0.258
ENSG00000259129 E006 2.9121154 0.009082832 0.68787264 0.8277409 14 47766928 47767064 137 - 0.556 0.628 0.325
ENSG00000259129 E007 3.0314047 0.009259389 0.52053286 0.7152846 14 47767065 47767268 204 - 0.556 0.663 0.475
ENSG00000259129 E008 2.1009206 0.011140350 0.95843880 0.9811048 14 47767269 47767599 331 - 0.480 0.500 0.097
ENSG00000259129 E009 1.2852840 0.020277093 0.79782437   14 47767600 47767757 158 - 0.334 0.387 0.318
ENSG00000259129 E010 0.4458772 0.023959831 0.46563125   14 47768831 47768910 80 - 0.110 0.236 1.322
ENSG00000259129 E011 0.0000000       14 47789037 47789069 33 -      
ENSG00000259129 E012 5.4178843 0.006545723 0.27961092 0.5197159 14 47789906 47789943 38 - 0.727 0.875 0.586
ENSG00000259129 E013 2.3111697 0.428967637 0.40354661 0.6311505 14 47794972 47795302 331 - 0.564 0.410 -0.762
ENSG00000259129 E014 7.8060368 0.225129466 0.18903786 0.4157609 14 47900624 47900737 114 - 0.816 1.068 0.946
ENSG00000259129 E015 0.4054685 0.520759399 0.26691866   14 47900738 47900740 3 - 0.000 0.247 10.668
ENSG00000259129 E016 6.3447529 0.111096693 0.20914181 0.4408720 14 47901526 47901739 214 - 0.763 0.979 0.829