ENSG00000257337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000546793 ENSG00000257337 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 2.65664 3.601916 1.295069 0.6212132 0.2436683 -1.468638 0.94960506 1.4181816 0.41812922 0.14799368 0.09110069 -1.7380612 0.35584583 0.4064667 0.34493333 -0.061533333 0.862611148 0.000706381 FALSE TRUE
ENST00000551890 ENSG00000257337 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 2.65664 3.601916 1.295069 0.6212132 0.2436683 -1.468638 0.16308460 0.1280963 0.08540713 0.07252879 0.04331517 -0.5335054 0.05648750 0.0320000 0.05556667 0.023566667 0.876633773 0.000706381   FALSE
ENST00000607643 ENSG00000257337 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 2.65664 3.601916 1.295069 0.6212132 0.2436683 -1.468638 0.17490648 0.1492782 0.02947268 0.01880581 0.02947268 -2.0126220 0.06254583 0.0438000 0.03603333 -0.007766667 0.807926468 0.000706381   FALSE
ENST00000657514 ENSG00000257337 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 2.65664 3.601916 1.295069 0.6212132 0.2436683 -1.468638 0.07462507 0.0000000 0.31142492 0.00000000 0.17186137 5.0064099 0.03741250 0.0000000 0.21186667 0.211866667 0.000706381 0.000706381 TRUE FALSE
ENST00000688419 ENSG00000257337 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 2.65664 3.601916 1.295069 0.6212132 0.2436683 -1.468638 0.88132062 1.2119942 0.13604680 0.23464327 0.06932373 -3.0647347 0.31392500 0.3334667 0.13423333 -0.199233333 0.447097976 0.000706381   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000257337 E001 0.5339515 1.081494702 1.274613e-01   12 53012884 53014595 1712 - 0.479 0.000 -14.222
ENSG00000257337 E002 0.3559677 0.694334608 8.937158e-02   12 53014596 53014943 348 - 0.364 0.000 -16.077
ENSG00000257337 E003 0.0000000       12 53018779 53018959 181 -      
ENSG00000257337 E004 0.0000000       12 53038953 53038957 5 -      
ENSG00000257337 E005 0.0000000       12 53038958 53038961 4 -      
ENSG00000257337 E006 0.0000000       12 53038962 53038962 1 -      
ENSG00000257337 E007 0.0000000       12 53038963 53038966 4 -      
ENSG00000257337 E008 0.6082027 0.772074616 1.000000e+00   12 53038967 53038968 2 - 0.000 0.189 13.564
ENSG00000257337 E009 0.6082027 0.772074616 1.000000e+00   12 53038969 53038970 2 - 0.000 0.189 13.564
ENSG00000257337 E010 0.6082027 0.772074616 1.000000e+00   12 53038971 53038972 2 - 0.000 0.189 13.564
ENSG00000257337 E011 0.6082027 0.772074616 1.000000e+00   12 53038973 53038985 13 - 0.000 0.189 13.564
ENSG00000257337 E012 0.6082027 0.772074616 1.000000e+00   12 53038986 53038996 11 - 0.000 0.189 13.564
ENSG00000257337 E013 0.8699390 0.038558428 2.912326e-01   12 53038997 53039019 23 - 0.000 0.261 14.579
ENSG00000257337 E014 1.5786500 0.031973320 8.916812e-02 0.2622492645 12 53039020 53039106 87 - 0.000 0.396 15.267
ENSG00000257337 E015 0.8395791 0.017028805 2.824826e-01   12 53039107 53039109 3 - 0.000 0.261 14.598
ENSG00000257337 E016 6.5738692 0.007210300 3.788431e-05 0.0006583384 12 53039110 53039717 608 - 1.155 0.648 -1.945
ENSG00000257337 E017 0.0000000       12 53039718 53039728 11 -      
ENSG00000257337 E018 1.5857662 0.916982391 5.474397e-01 0.7344360196 12 53039729 53039873 145 - 0.643 0.243 -2.177
ENSG00000257337 E019 4.0547808 0.148948798 1.651802e-02 0.0837055143 12 53039874 53040263 390 - 0.973 0.469 -2.110
ENSG00000257337 E020 1.5973290 0.015329457 1.697450e-01 0.3901549865 12 53042705 53042884 180 - 0.548 0.298 -1.361
ENSG00000257337 E021 2.2330585 0.011162240 8.359506e-01 0.9171285042 12 53042885 53043097 213 - 0.462 0.423 -0.205
ENSG00000257337 E022 2.1917400 0.010603341 3.972410e-01 0.6261198779 12 53043098 53043147 50 - 0.548 0.395 -0.774
ENSG00000257337 E023 16.3686538 0.002297826 4.845620e-01 0.6902363622 12 53043189 53044014 826 - 1.093 1.161 0.244
ENSG00000257337 E024 30.3043717 0.010401544 4.604693e-01 0.6734822082 12 53044015 53045064 1050 - 1.364 1.419 0.191
ENSG00000257337 E025 9.3051425 0.004482611 7.525660e-01 0.8683011913 12 53045065 53045186 122 - 0.901 0.940 0.148
ENSG00000257337 E026 4.5264745 0.012331173 5.393830e-01 0.7285551255 12 53045187 53045224 38 - 0.734 0.634 -0.422
ENSG00000257337 E027 20.6874020 0.001797014 4.539224e-01 0.6686889444 12 53045225 53045586 362 - 1.192 1.258 0.231
ENSG00000257337 E028 11.5967079 0.002870896 8.438956e-01 0.9215398689 12 53045587 53045599 13 - 0.994 1.016 0.080
ENSG00000257337 E029 15.1770578 0.002869023 9.605432e-01 0.9821321192 12 53045600 53045653 54 - 1.115 1.119 0.016
ENSG00000257337 E030 0.4644705 0.024441170 5.975460e-01   12 53045654 53045960 307 - 0.000 0.174 13.971
ENSG00000257337 E031 12.4971944 0.003126475 8.431481e-01 0.9212477138 12 53045961 53046007 47 - 1.021 1.043 0.079
ENSG00000257337 E032 14.8549752 0.002722381 5.805977e-01 0.7575610655 12 53046008 53046061 54 - 1.070 1.125 0.197
ENSG00000257337 E033 0.9332605 0.307238083 6.234359e-01   12 53046847 53046852 6 - 0.351 0.220 -0.917
ENSG00000257337 E034 7.5720084 0.004879509 1.725832e-01 0.3939009147 12 53046853 53047095 243 - 0.681 0.880 0.794
ENSG00000257337 E035 0.3032425 0.027442404 1.000000e+00   12 53047904 53047947 44 - 0.000 0.123 13.460
ENSG00000257337 E036 1.1305778 0.255201611 7.540701e-01   12 53053104 53053395 292 - 0.212 0.320 0.796
ENSG00000257337 E037 12.9575621 0.033544708 5.792435e-01 0.7566409741 12 53053396 53053574 179 - 1.017 1.079 0.226
ENSG00000257337 E038 5.7546597 0.013266128 1.219980e-01 0.3190323130 12 53054321 53054450 130 - 0.548 0.806 1.094