ENSG00000257267

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399070 ENSG00000257267 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF271P transcribed_unitary_pseudogene processed_transcript 33.03586 12.43813 48.15684 1.732175 3.258918 1.952111 5.093400 1.565138 8.559861 0.1706278 0.1117027 2.443794 0.1412500 0.1272667 0.1791000 0.05183333 0.30421606 0.003974952 FALSE TRUE
ENST00000638208 ENSG00000257267 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF271P transcribed_unitary_pseudogene processed_transcript 33.03586 12.43813 48.15684 1.732175 3.258918 1.952111 6.232877 1.620452 12.747448 0.3255260 1.1112769 2.967996 0.1651875 0.1327667 0.2640333 0.13126667 0.05394784 0.003974952 FALSE TRUE
MSTRG.15688.10 ENSG00000257267 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF271P transcribed_unitary_pseudogene   33.03586 12.43813 48.15684 1.732175 3.258918 1.952111 8.679963 2.192033 13.407724 0.3841793 0.5629599 2.607232 0.2494875 0.1741667 0.2802000 0.10603333 0.04363812 0.003974952 FALSE FALSE
MSTRG.15688.8 ENSG00000257267 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF271P transcribed_unitary_pseudogene   33.03586 12.43813 48.15684 1.732175 3.258918 1.952111 9.631828 4.669865 10.824475 1.0241959 2.3688768 1.211090 0.3249250 0.3667000 0.2201667 -0.14653333 0.30944692 0.003974952   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000257267 E001 0.3393995 0.0270040994 9.581814e-01   18 35290282 35290290 9 + 0.129 0.000 -8.430
ENSG00000257267 E002 0.3393995 0.0270040994 9.581814e-01   18 35290291 35290293 3 + 0.129 0.000 -10.156
ENSG00000257267 E003 1.3824187 0.0134991286 3.941290e-01   18 35290294 35290313 20 + 0.376 0.205 -1.188
ENSG00000257267 E004 1.8892032 0.0158048418 6.402853e-01 7.970884e-01 18 35290314 35290314 1 + 0.434 0.344 -0.508
ENSG00000257267 E005 12.4410880 0.0033260803 1.444237e-01 3.540322e-01 18 35290315 35290323 9 + 1.019 1.174 0.557
ENSG00000257267 E006 107.2652962 0.0007514833 2.269962e-07 7.705211e-06 18 35290324 35290383 60 + 1.908 2.107 0.666
ENSG00000257267 E007 122.8049523 0.0003675152 1.850502e-07 6.436318e-06 18 35290384 35290391 8 + 1.970 2.154 0.614
ENSG00000257267 E008 1.3995344 0.2743643133 9.546694e-01 9.792534e-01 18 35290392 35290397 6 + 0.338 0.347 0.054
ENSG00000257267 E009 7.4735291 0.0042216795 7.016195e-02 2.251102e-01 18 35290398 35291009 612 + 0.802 1.028 0.859
ENSG00000257267 E010 132.0402975 0.0003929270 5.890648e-06 1.328509e-04 18 35291010 35291073 64 + 2.009 2.164 0.522
ENSG00000257267 E011 237.2561673 0.0006001005 5.448433e-05 8.966501e-04 18 35291074 35291232 159 + 2.273 2.383 0.364
ENSG00000257267 E012 634.1573061 0.0001686913 2.608124e-07 8.718886e-06 18 35305976 35307023 1048 + 2.743 2.668 -0.251
ENSG00000257267 E013 500.2688285 0.0001963637 1.476575e-26 8.829452e-24 18 35307024 35308549 1526 + 2.663 2.464 -0.662
ENSG00000257267 E014 233.0084910 0.0003219891 3.376344e-03 2.562315e-02 18 35308550 35310766 2217 + 2.308 2.228 -0.267
ENSG00000257267 E015 11.6270307 0.0034488152 2.793851e-08 1.185854e-06 18 35322388 35322501 114 + 0.825 1.380 2.016
ENSG00000257267 E016 1.4582786 0.0122249616 1.471586e-01 3.582516e-01 18 35324980 35325013 34 + 0.270 0.534 1.489
ENSG00000257267 E017 2.6782134 0.0098023183 1.507743e-03 1.367041e-02 18 35325044 35325141 98 + 0.343 0.848 2.327
ENSG00000257267 E018 14.2590880 0.0051199420 2.699501e-13 3.089200e-11 18 35326797 35327063 267 + 0.836 1.519 2.451
ENSG00000257267 E019 8.5482224 0.0328889018 7.796597e-03 4.836681e-02 18 35327064 35328075 1012 + 0.793 1.156 1.353
ENSG00000257267 E020 1.9813710 0.0112394617 1.239942e-03 1.171725e-02 18 35328076 35328128 53 + 0.227 0.767 2.815
ENSG00000257267 E021 5.0902513 0.0063307765 1.219558e-04 1.761581e-03 18 35328129 35328390 262 + 0.533 1.053 2.095
ENSG00000257267 E022 1.5893344 0.0124267573 2.178375e-01 4.508472e-01 18 35339805 35339890 86 + 0.308 0.534 1.225
ENSG00000257267 E023 12.6970295 0.0030222802 1.503830e-16 2.812609e-14 18 35343737 35344476 740 + 0.738 1.519 2.841