ENSG00000257103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000433627 ENSG00000257103 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM14A protein_coding protein_coding 58.90772 28.94989 100.5138 5.87978 2.5118 1.795409 7.384786 3.0624786 14.68033 0.8736213 1.4899824 2.257392 0.14561667 0.1030667 0.1456667 0.042600000 5.262705e-01 1.695201e-15 FALSE TRUE
ENST00000544216 ENSG00000257103 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM14A protein_coding protein_coding 58.90772 28.94989 100.5138 5.87978 2.5118 1.795409 22.438586 13.6760420 31.90207 2.9553064 0.9687563 1.221397 0.41095000 0.4695667 0.3172667 -0.152300000 3.051131e-04 1.695201e-15 FALSE TRUE
ENST00000585887 ENSG00000257103 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM14A protein_coding non_stop_decay 58.90772 28.94989 100.5138 5.87978 2.5118 1.795409 17.483733 9.5421535 32.11561 2.1742135 1.2117620 1.749826 0.28901667 0.3286667 0.3200000 -0.008666667 9.849556e-01 1.695201e-15 FALSE FALSE
ENST00000586157 ENSG00000257103 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM14A protein_coding protein_coding 58.90772 28.94989 100.5138 5.87978 2.5118 1.795409 6.539948 0.8230573 16.21951 0.1312435 1.0708520 4.284060 0.07363333 0.0294000 0.1610333 0.131633333 1.695201e-15 1.695201e-15 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000257103 E001 0.1723744 0.0602592095 1.926807e-01   19 34172283 34172433 151 + 0.000 0.179 9.519
ENSG00000257103 E002 7.8252406 0.1038545379 5.125202e-01 7.098649e-01 19 34172434 34172503 70 + 0.876 0.961 0.322
ENSG00000257103 E003 18.4846437 0.0588872447 2.786079e-01 5.186879e-01 19 34172504 34172524 21 + 1.206 1.336 0.458
ENSG00000257103 E004 54.6998513 0.0160240371 8.286490e-03 5.064006e-02 19 34172525 34172567 43 + 1.634 1.849 0.729
ENSG00000257103 E005 119.8349665 0.0032366497 1.539281e-01 3.679329e-01 19 34172568 34172657 90 + 2.024 2.098 0.248
ENSG00000257103 E006 309.4548769 0.0001859883 5.319829e-02 1.872612e-01 19 34172658 34172763 106 + 2.464 2.428 -0.119
ENSG00000257103 E007 496.4929683 0.0001437046 4.165357e-07 1.319973e-05 19 34194478 34194641 164 + 2.680 2.597 -0.276
ENSG00000257103 E008 0.7499275 0.0174932161 6.023245e-01   19 34195219 34195320 102 + 0.208 0.305 0.731
ENSG00000257103 E009 280.0177654 0.0002407454 9.279538e-05 1.405028e-03 19 34196634 34196666 33 + 2.432 2.345 -0.292
ENSG00000257103 E010 359.0166268 0.0001706634 2.611172e-02 1.156742e-01 19 34196667 34196763 97 + 2.529 2.490 -0.129
ENSG00000257103 E011 3.2795599 0.0073995107 9.665732e-01 9.851777e-01 19 34208196 34208928 733 + 0.609 0.608 -0.007
ENSG00000257103 E012 413.6952786 0.0004486234 3.255852e-01 5.647963e-01 19 34208929 34209051 123 + 2.571 2.598 0.089
ENSG00000257103 E013 493.0271074 0.0001508039 1.266576e-01 3.265032e-01 19 34215124 34215300 177 + 2.645 2.678 0.112
ENSG00000257103 E014 279.6619709 0.0002773304 5.813819e-01 7.580776e-01 19 34215596 34215657 62 + 2.403 2.424 0.068
ENSG00000257103 E015 102.2555112 0.0004454750 9.973622e-02 2.812885e-01 19 34215658 34215661 4 + 1.956 2.026 0.235
ENSG00000257103 E016 341.9809476 0.0001957904 5.875049e-01 7.619910e-01 19 34219391 34219573 183 + 2.498 2.494 -0.014
ENSG00000257103 E017 156.9149358 0.0003479589 6.111159e-02 2.052641e-01 19 34219706 34219708 3 + 2.174 2.121 -0.175
ENSG00000257103 E018 487.3502967 0.0001475632 1.850115e-02 9.072472e-02 19 34219709 34219877 169 + 2.658 2.624 -0.115
ENSG00000257103 E019 1.0129490 0.1424981551 3.004772e-01   19 34221350 34221506 157 + 0.207 0.407 1.343
ENSG00000257103 E020 538.3079342 0.0001284967 1.576960e-01 3.732566e-01 19 34221507 34221738 232 + 2.683 2.714 0.103
ENSG00000257103 E021 1.9470173 0.4779235146 5.583572e-01 7.421005e-01 19 34221739 34221779 41 + 0.379 0.564 0.938
ENSG00000257103 E022 71.9032543 0.0006903867 2.746386e-01 5.146136e-01 19 34226408 34226464 57 + 1.839 1.796 -0.146
ENSG00000257103 E023 144.2743904 0.0022347404 4.027800e-02 1.554328e-01 19 34227365 34227368 4 + 2.099 2.184 0.284
ENSG00000257103 E024 1256.6158835 0.0007867803 8.094209e-03 4.976506e-02 19 34227369 34229288 1920 + 3.045 3.091 0.150