ENSG00000255468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000531602 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 0.4355131 0.7562341 0.00000000 0.3034179 0.00000000 -6.259713 0.07143750 0.08103333 0.00000000 -0.08103333 0.02031942 0.02031942 FALSE  
ENST00000580881 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 0.4799495 0.7677087 0.29526903 0.2961976 0.12577869 -1.349149 0.09724583 0.09326667 0.15083333 0.05756667 0.83834701 0.02031942    
ENST00000649789 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 0.3972208 0.7936401 0.37445443 0.2631897 0.12021779 -1.063737 0.08737500 0.11393333 0.18196667 0.06803333 0.73775347 0.02031942 FALSE  
MSTRG.5771.1 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA   5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 1.9338934 2.7016774 0.93248064 0.4674119 0.10169836 -1.524651 0.39421250 0.31706667 0.46470000 0.14763333 0.16797016 0.02031942 FALSE  
MSTRG.5771.2 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA   5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 1.2788655 2.5396858 0.04421079 0.8714841 0.04421079 -5.555596 0.18789583 0.27463333 0.02606667 -0.24856667 0.05832942 0.02031942 TRUE  
MSTRG.5771.3 ENSG00000255468 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA   5.398765 8.555895 2.004949 1.492629 0.2079674 -2.087861 0.6688699 0.9969486 0.35853379 0.1273881 0.07996897 -1.450121 0.13640833 0.12013333 0.17643333 0.05630000 0.62752938 0.02031942    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000255468 E001 0.9518539 0.016055504 1.00000000   11 66347738 66347784 47 + 0.233 0.238 0.038
ENSG00000255468 E002 2.0284189 0.010527479 0.92114466 0.96280973 11 66347785 66347802 18 + 0.385 0.416 0.172
ENSG00000255468 E003 25.4012244 0.034674088 0.01295343 0.07026738 11 66347803 66347949 147 + 0.982 1.343 1.290
ENSG00000255468 E004 34.7583544 0.010926997 0.04753312 0.17386526 11 66347950 66348070 121 + 1.258 1.460 0.703
ENSG00000255468 E005 7.0186239 0.007722936 0.23824862 0.47460522 11 66348071 66348214 144 + 0.909 0.755 -0.600
ENSG00000255468 E006 4.8445674 0.005890770 0.33972519 0.57774594 11 66348215 66348284 70 + 0.777 0.640 -0.567
ENSG00000255468 E007 3.5105904 0.008207205 0.08149833 0.24782957 11 66348285 66348348 64 + 0.777 0.504 -1.183
ENSG00000255468 E008 4.7204241 0.006230369 0.06786338 0.22029557 11 66349335 66349470 136 + 0.870 0.609 -1.063
ENSG00000255468 E009 1.3867724 0.012996869 0.22160664   11 66351197 66351374 178 + 0.496 0.273 -1.285
ENSG00000255468 E010 22.2028326 0.021179299 0.29934908 0.53974472 11 66353455 66353615 161 + 1.118 1.261 0.508
ENSG00000255468 E011 0.3503582 0.032189821 0.23841603   11 66353616 66353619 4 + 0.234 0.059 -2.285
ENSG00000255468 E012 1.2966026 0.052082831 0.76113957   11 66358201 66358224 24 + 0.233 0.306 0.529
ENSG00000255468 E013 1.8692839 0.045590027 0.13561409 0.34073667 11 66358225 66358322 98 + 0.585 0.308 -1.467
ENSG00000255468 E014 0.8571428 0.017525946 0.02978274   11 66358323 66358335 13 + 0.496 0.112 -2.867
ENSG00000255468 E015 6.5211953 0.126718319 0.81108388 0.90293160 11 66360163 66360650 488 + 0.717 0.780 0.252
ENSG00000255468 E016 12.4955505 0.154880304 0.99763973 1.00000000 11 66360651 66360744 94 + 1.030 1.017 -0.047
ENSG00000255468 E017 70.5170840 0.001065994 0.07574299 0.23625498 11 66363269 66364190 922 + 1.779 1.717 -0.208
ENSG00000255468 E018 14.4503143 0.015704779 0.98587830 0.99477027 11 66364525 66364804 280 + 1.066 1.088 0.077