ENSG00000254087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420292 ENSG00000254087 HEK293_OSMI2_6hA HEK293_TMG_6hB LYN protein_coding processed_transcript 7.811619 3.730973 7.896949 0.530816 0.2913022 1.079708 1.110284 0.0000000 1.5884536 0.0000000 0.2695207 7.32053309 0.1072792 0.00000000 0.2042333 0.2042333 7.108107e-08 7.108107e-08 FALSE FALSE
ENST00000519728 ENSG00000254087 HEK293_OSMI2_6hA HEK293_TMG_6hB LYN protein_coding protein_coding 7.811619 3.730973 7.896949 0.530816 0.2913022 1.079708 2.885265 2.7191216 2.4861541 0.6256605 0.3230365 -0.12872968 0.4535708 0.70803333 0.3132333 -0.3948000 6.004926e-03 7.108107e-08 FALSE TRUE
ENST00000520050 ENSG00000254087 HEK293_OSMI2_6hA HEK293_TMG_6hB LYN protein_coding protein_coding 7.811619 3.730973 7.896949 0.530816 0.2913022 1.079708 2.274121 0.1416943 2.9440919 0.1416943 0.3557208 4.28347613 0.2193625 0.05256667 0.3705333 0.3179667 1.184959e-01 7.108107e-08 FALSE FALSE
ENST00000520220 ENSG00000254087 HEK293_OSMI2_6hA HEK293_TMG_6hB LYN protein_coding protein_coding 7.811619 3.730973 7.896949 0.530816 0.2913022 1.079708 1.541949 0.8701572 0.8782493 0.1140421 0.2477335 0.01320349 0.2197833 0.23940000 0.1120333 -0.1273667 3.007424e-01 7.108107e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000254087 E001 19.6404832 0.0026866009 4.330049e-01 0.6534919975 8 55879835 55880103 269 + 1.277 1.341 0.222
ENSG00000254087 E002 0.0000000       8 55940234 55940327 94 +      
ENSG00000254087 E003 28.3012139 0.0013333722 2.479744e-01 0.4858301513 8 55941855 55941928 74 + 1.507 1.434 -0.250
ENSG00000254087 E004 25.7247142 0.0014394442 1.620764e-03 0.0144681989 8 55941929 55941991 63 + 1.529 1.316 -0.735
ENSG00000254087 E005 34.3490844 0.0011577468 3.535139e-02 0.1424946908 8 55946448 55946493 46 + 1.608 1.485 -0.421
ENSG00000254087 E006 48.9365065 0.0012393491 6.584402e-03 0.0426283015 8 55947618 55947723 106 + 1.767 1.632 -0.459
ENSG00000254087 E007 47.4252320 0.0011332904 1.306390e-01 0.3327909813 8 55950459 55950557 99 + 1.727 1.653 -0.253
ENSG00000254087 E008 50.6401988 0.0008667673 9.500060e-02 0.2729624863 8 55950681 55950784 104 + 1.754 1.674 -0.272
ENSG00000254087 E009 61.2013526 0.0013354939 2.282921e-01 0.4632428072 8 55951966 55952115 150 + 1.819 1.764 -0.185
ENSG00000254087 E010 64.8185875 0.0006151250 9.699226e-01 0.9867974659 8 55953832 55953984 153 + 1.817 1.819 0.009
ENSG00000254087 E011 0.1308682 0.0326491905 5.275397e-01   8 55955096 55955293 198 + 0.000 0.116 8.605
ENSG00000254087 E012 68.8464467 0.0008244136 6.402180e-01 0.7970331298 8 55966715 55966897 183 + 1.832 1.854 0.074
ENSG00000254087 E013 49.2229299 0.0009639091 4.619318e-01 0.6744511159 8 55969717 55969793 77 + 1.719 1.685 -0.116
ENSG00000254087 E014 60.1516787 0.0006484190 4.979862e-01 0.6994707513 8 55998346 55998499 154 + 1.767 1.799 0.107
ENSG00000254087 E015 54.3298618 0.0009517732 1.596282e-01 0.3762357107 8 55999418 55999549 132 + 1.702 1.770 0.231
ENSG00000254087 E016 297.6405299 0.0003873671 5.774386e-06 0.0001306453 8 56009908 56014169 4262 + 2.427 2.510 0.278