ENSG00000253729

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314191 ENSG00000253729 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKDC protein_coding protein_coding 101.9213 133.9776 102.1738 47.75095 5.96996 -0.3909325 45.142408 44.72903 61.2088590 13.684695 3.288317 0.4524423 0.45237917 0.36013333 0.5994333 0.23930000 0.0010920350 6.772923e-22 FALSE TRUE
ENST00000521331 ENSG00000253729 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKDC protein_coding retained_intron 101.9213 133.9776 102.1738 47.75095 5.96996 -0.3909325 4.200513 10.71237 0.3143491 5.045644 0.117064 -5.0469322 0.03750833 0.06526667 0.0032000 -0.06206667 0.0004349175 6.772923e-22 FALSE FALSE
ENST00000536429 ENSG00000253729 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKDC protein_coding protein_coding 101.9213 133.9776 102.1738 47.75095 5.96996 -0.3909325 11.539305 24.88325 3.3839112 11.178235 1.788788 -2.8747337 0.10740833 0.17250000 0.0314000 -0.14110000 0.4770168361 6.772923e-22 FALSE TRUE
ENST00000536483 ENSG00000253729 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKDC protein_coding retained_intron 101.9213 133.9776 102.1738 47.75095 5.96996 -0.3909325 33.509981 52.06443 23.2390454 18.959541 1.524339 -1.1634037 0.32369167 0.38103333 0.2281667 -0.15286667 0.0012711175 6.772923e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000253729 E001 1958.7597999 1.091914e-02 1.407507e-12 1.409358e-10 8 47773111 47773734 624 - 3.066 3.460 1.311
ENSG00000253729 E002 1764.4980696 7.304473e-03 7.374313e-14 9.430180e-12 8 47773735 47773986 252 - 3.056 3.397 1.134
ENSG00000253729 E003 1188.3361156 8.961332e-03 2.430991e-09 1.313516e-07 8 47773987 47774133 147 - 2.902 3.215 1.040
ENSG00000253729 E004 1416.1643284 6.196833e-03 1.199159e-10 8.363236e-09 8 47774134 47774377 244 - 3.001 3.278 0.921
ENSG00000253729 E005 847.6322848 4.231134e-03 1.730063e-12 1.704202e-10 8 47776844 47776983 140 - 2.786 3.050 0.880
ENSG00000253729 E006 974.1407454 1.904529e-03 8.665736e-22 3.137828e-19 8 47777686 47777874 189 - 2.855 3.105 0.830
ENSG00000253729 E007 758.8992465 2.301580e-03 3.050929e-15 4.801834e-13 8 47778459 47778536 78 - 2.758 2.989 0.767
ENSG00000253729 E008 894.3104696 9.250591e-04 7.391880e-33 7.607947e-30 8 47778537 47778660 124 - 2.824 3.063 0.792
ENSG00000253729 E009 22.5816893 1.688273e-01 2.705690e-01 5.105177e-01 8 47778661 47778719 59 - 1.475 1.205 -0.943
ENSG00000253729 E010 733.2834882 1.050149e-03 2.978126e-25 1.551394e-22 8 47778728 47778799 72 - 2.745 2.972 0.754
ENSG00000253729 E011 671.4663391 6.375343e-03 6.164711e-06 1.379873e-04 8 47779004 47779093 90 - 2.714 2.929 0.714
ENSG00000253729 E012 8.2297156 1.237114e-01 9.518335e-01 9.778720e-01 8 47779094 47779361 268 - 0.986 0.934 -0.194
ENSG00000253729 E013 698.7534631 1.244147e-03 1.139999e-17 2.475678e-15 8 47782162 47782254 93 - 2.742 2.940 0.662
ENSG00000253729 E014 502.7750512 3.393037e-03 2.185409e-10 1.442412e-08 8 47782378 47782413 36 - 2.587 2.807 0.734
ENSG00000253729 E015 974.6224931 6.854350e-04 9.548152e-33 9.709556e-30 8 47782414 47782598 185 - 2.879 3.091 0.706
ENSG00000253729 E016 1.9933978 1.056006e-02 3.973517e-01 6.262245e-01 8 47782599 47783007 409 - 0.524 0.384 -0.722
ENSG00000253729 E017 589.3386716 1.640143e-04 6.194288e-41 1.107298e-37 8 47783742 47783809 68 - 2.657 2.876 0.728
ENSG00000253729 E018 2.0549024 3.396859e-02 3.896401e-01 6.201952e-01 8 47783810 47784139 330 - 0.393 0.544 0.764
ENSG00000253729 E019 858.0772582 8.214063e-04 1.827857e-25 9.792184e-23 8 47785113 47785317 205 - 2.828 3.030 0.672
ENSG00000253729 E020 570.9460375 2.445832e-03 2.015509e-08 8.830747e-07 8 47788906 47789049 144 - 2.667 2.840 0.577
ENSG00000253729 E021 489.2212348 1.535238e-03 3.887242e-09 1.995596e-07 8 47789151 47789238 88 - 2.608 2.766 0.527
ENSG00000253729 E022 873.6191088 6.931502e-04 4.181002e-19 1.075804e-16 8 47794290 47794501 212 - 2.858 3.020 0.540
ENSG00000253729 E023 655.2308557 2.011031e-03 2.726156e-09 1.450843e-07 8 47798237 47798382 146 - 2.731 2.896 0.549
ENSG00000253729 E024 265.4375643 3.167295e-04 1.007369e-13 1.253292e-11 8 47798383 47798397 15 - 2.331 2.512 0.603
ENSG00000253729 E025 676.5984167 9.833121e-05 8.680760e-28 5.944325e-25 8 47799210 47799390 181 - 2.748 2.912 0.546
ENSG00000253729 E026 684.7659477 1.129827e-04 1.626248e-26 9.656442e-24 8 47800793 47800986 194 - 2.755 2.915 0.534
ENSG00000253729 E027 644.9133726 9.694892e-05 1.995230e-17 4.167725e-15 8 47803306 47803480 175 - 2.745 2.877 0.438
ENSG00000253729 E028 749.0910397 1.031543e-04 2.836836e-04 3.564368e-03 8 47807137 47807326 190 - 2.848 2.906 0.194
ENSG00000253729 E029 711.4261583 1.568548e-03 1.683536e-01 3.883524e-01 8 47817450 47817561 112 - 2.864 2.837 -0.089
ENSG00000253729 E030 584.8548243 1.243851e-03 7.045887e-02 2.256371e-01 8 47819402 47819499 98 - 2.782 2.750 -0.104
ENSG00000253729 E031 290.5358250 2.138736e-04 2.416018e-01 4.783782e-01 8 47819500 47819510 11 - 2.472 2.456 -0.054
ENSG00000253729 E032 691.6304503 9.908396e-05 5.468832e-01 7.340735e-01 8 47820719 47820943 225 - 2.833 2.850 0.057
ENSG00000253729 E033 567.7767074 1.496132e-04 3.772901e-01 6.101174e-01 8 47821604 47821792 189 - 2.745 2.767 0.072
ENSG00000253729 E034 457.4395017 5.145013e-04 8.665578e-01 9.341034e-01 8 47823858 47823996 139 - 2.659 2.663 0.015
ENSG00000253729 E035 490.3091460 5.717920e-04 4.015017e-01 6.295401e-01 8 47826656 47826861 206 - 2.680 2.706 0.086
ENSG00000253729 E036 457.0054153 1.145914e-03 4.311573e-02 1.628749e-01 8 47828168 47828347 180 - 2.680 2.637 -0.144
ENSG00000253729 E037 433.2935287 6.827068e-04 3.961056e-02 1.537340e-01 8 47830605 47830736 132 - 2.655 2.616 -0.129
ENSG00000253729 E038 449.4108162 3.718946e-03 4.296568e-01 6.507685e-01 8 47831814 47831926 113 - 2.668 2.634 -0.112
ENSG00000253729 E039 569.5242328 3.127911e-03 2.101742e-01 4.420496e-01 8 47834196 47834396 201 - 2.774 2.734 -0.135
ENSG00000253729 E040 536.3326825 1.169304e-04 1.559544e-02 8.034902e-02 8 47836338 47836527 190 - 2.744 2.713 -0.102
ENSG00000253729 E041 532.8561224 1.096219e-04 6.191672e-02 2.071195e-01 8 47837212 47837419 208 - 2.737 2.715 -0.072
ENSG00000253729 E042 400.2065613 4.552975e-04 2.156098e-05 4.072009e-04 8 47839148 47839246 99 - 2.639 2.560 -0.264
ENSG00000253729 E043 51.2413795 8.450099e-04 6.325596e-03 4.132773e-02 8 47839247 47839249 3 - 1.774 1.643 -0.444
ENSG00000253729 E044 569.2095219 1.041508e-03 8.759975e-07 2.530439e-05 8 47840016 47840189 174 - 2.801 2.699 -0.340
ENSG00000253729 E045 536.8963444 1.355775e-04 5.430701e-16 9.430041e-14 8 47849154 47849303 150 - 2.783 2.659 -0.414
ENSG00000253729 E046 433.2032761 1.510352e-04 5.816937e-11 4.323193e-09 8 47849379 47849503 125 - 2.684 2.574 -0.368
ENSG00000253729 E047 350.4613187 1.863334e-04 1.141551e-09 6.596176e-08 8 47852673 47852784 112 - 2.595 2.482 -0.378
ENSG00000253729 E048 387.3667951 4.169947e-04 9.461892e-10 5.552339e-08 8 47854083 47854214 132 - 2.641 2.522 -0.398
ENSG00000253729 E049 362.6060284 1.678540e-04 9.840893e-18 2.156400e-15 8 47855222 47855373 152 - 2.627 2.465 -0.539
ENSG00000253729 E050 332.4246862 6.903600e-03 1.450912e-03 1.327147e-02 8 47857156 47857299 144 - 2.588 2.427 -0.538
ENSG00000253729 E051 304.0828972 9.422651e-04 3.474920e-13 3.892620e-11 8 47858516 47858635 120 - 2.560 2.376 -0.613
ENSG00000253729 E052 338.5296090 1.064422e-02 1.758038e-03 1.542191e-02 8 47858849 47858980 132 - 2.606 2.419 -0.622
ENSG00000253729 E053 149.4051908 5.260100e-03 5.910838e-05 9.612145e-04 8 47858981 47858986 6 - 2.254 2.063 -0.638
ENSG00000253729 E054 351.0425760 4.941765e-03 5.929780e-06 1.335915e-04 8 47859611 47859759 149 - 2.622 2.435 -0.624
ENSG00000253729 E055 256.8930700 6.131260e-03 9.212909e-06 1.955216e-04 8 47860899 47860971 73 - 2.494 2.285 -0.697
ENSG00000253729 E056 247.6158387 1.530097e-02 5.104084e-03 3.517569e-02 8 47862062 47862127 66 - 2.476 2.273 -0.679
ENSG00000253729 E057 0.1614157 3.700542e-02 6.159625e-01   8 47862369 47862372 4 - 0.112 0.000 -9.574
ENSG00000253729 E058 410.1271532 5.920017e-03 3.056193e-08 1.283095e-06 8 47862373 47862541 169 - 2.709 2.464 -0.815
ENSG00000253729 E059 503.2909015 8.817981e-03 2.260136e-08 9.798904e-07 8 47863399 47863577 179 - 2.812 2.521 -0.970
ENSG00000253729 E060 456.0468597 1.427386e-02 3.890785e-05 6.727191e-04 8 47864556 47864763 208 - 2.763 2.492 -0.903
ENSG00000253729 E061 0.8580705 9.440725e-02 8.980021e-01   8 47864764 47864792 29 - 0.274 0.311 0.253
ENSG00000253729 E062 345.1491654 5.904074e-03 1.101280e-07 4.043732e-06 8 47877724 47877851 128 - 2.631 2.398 -0.779
ENSG00000253729 E063 404.0446176 3.210604e-03 1.910496e-13 2.245302e-11 8 47879491 47879658 168 - 2.705 2.455 -0.831
ENSG00000253729 E064 302.3020389 3.845978e-03 2.727474e-11 2.175612e-09 8 47881416 47881520 105 - 2.581 2.326 -0.848
ENSG00000253729 E065 405.2840749 1.770805e-03 3.092544e-29 2.334156e-26 8 47881912 47882097 186 - 2.727 2.411 -1.053
ENSG00000253729 E066 383.1278193 1.128699e-02 2.781146e-07 9.230066e-06 8 47885944 47886147 204 - 2.697 2.394 -1.011
ENSG00000253729 E067 303.2834796 1.112158e-02 5.860271e-06 1.323064e-04 8 47887547 47887705 159 - 2.587 2.314 -0.913
ENSG00000253729 E068 275.2103590 9.263035e-03 5.488870e-08 2.170282e-06 8 47888518 47888650 133 - 2.554 2.255 -0.995
ENSG00000253729 E069 368.0455372 9.740462e-03 2.994683e-08 1.259762e-06 8 47889014 47889222 209 - 2.681 2.376 -1.014
ENSG00000253729 E070 365.4441755 1.735852e-02 5.003389e-05 8.321325e-04 8 47890257 47890480 224 - 2.675 2.379 -0.985
ENSG00000253729 E071 350.3679863 2.155395e-02 6.606469e-04 7.103073e-03 8 47893139 47893387 249 - 2.651 2.373 -0.926
ENSG00000253729 E072 244.2154457 1.017855e-02 1.008500e-08 4.735045e-07 8 47897161 47897294 134 - 2.510 2.184 -1.089
ENSG00000253729 E073 211.0059583 1.979533e-02 2.068661e-06 5.374942e-05 8 47898470 47898569 100 - 2.456 2.096 -1.205
ENSG00000253729 E074 223.5981506 9.863705e-03 2.175439e-09 1.189114e-07 8 47900373 47900467 95 - 2.475 2.137 -1.127
ENSG00000253729 E075 369.4114550 3.980102e-03 1.610599e-19 4.422831e-17 8 47902569 47902795 227 - 2.693 2.354 -1.130
ENSG00000253729 E076 243.1758720 6.075105e-03 5.972369e-17 1.182104e-14 8 47904869 47904976 108 - 2.526 2.134 -1.309
ENSG00000253729 E077 289.3942919 2.266987e-02 4.506619e-06 1.052286e-04 8 47912410 47912562 153 - 2.597 2.218 -1.265
ENSG00000253729 E078 303.6063967 1.152645e-02 3.304154e-11 2.584622e-09 8 47913901 47914064 164 - 2.624 2.218 -1.354
ENSG00000253729 E079 257.4873421 1.139474e-02 1.191684e-12 1.199617e-10 8 47915328 47915418 91 - 2.561 2.123 -1.463
ENSG00000253729 E080 274.6148100 1.988079e-02 3.387844e-09 1.763205e-07 8 47918277 47918383 107 - 2.595 2.129 -1.556
ENSG00000253729 E081 0.3337900 9.746954e-02 8.753649e-01   8 47926833 47927193 361 - 0.112 0.132 0.279
ENSG00000253729 E082 331.8894156 2.787485e-02 1.392609e-07 5.006286e-06 8 47927194 47927353 160 - 2.681 2.199 -1.608
ENSG00000253729 E083 294.0061156 1.386075e-02 6.819765e-12 6.054119e-10 8 47927771 47927890 120 - 2.622 2.170 -1.506
ENSG00000253729 E084 207.3041519 4.128387e-03 5.181623e-21 1.718669e-18 8 47929092 47929178 87 - 2.459 2.060 -1.333
ENSG00000253729 E085 231.5746661 3.850548e-03 4.997561e-25 2.548651e-22 8 47929853 47930012 160 - 2.511 2.095 -1.391
ENSG00000253729 E086 202.1651891 6.144838e-03 7.091231e-18 1.592929e-15 8 47930672 47930787 116 - 2.453 2.033 -1.404
ENSG00000253729 E087 214.8644270 2.384852e-03 4.308629e-35 5.189392e-32 8 47933020 47933172 153 - 2.487 2.037 -1.505
ENSG00000253729 E088 219.2800319 2.173771e-02 2.976815e-07 9.793329e-06 8 47933965 47934090 126 - 2.488 2.067 -1.408
ENSG00000253729 E089 175.0472867 5.345132e-02 2.464779e-04 3.180912e-03 8 47935009 47935058 50 - 2.399 1.941 -1.535
ENSG00000253729 E090 265.6931718 2.377425e-02 5.928830e-08 2.324219e-06 8 47935732 47935900 169 - 2.580 2.120 -1.536
ENSG00000253729 E091 219.4918625 2.511319e-02 1.308250e-07 4.732938e-06 8 47936353 47936453 101 - 2.499 2.029 -1.572
ENSG00000253729 E092 158.0304464 2.498726e-02 1.367698e-06 3.731152e-05 8 47936454 47936517 64 - 2.350 1.915 -1.455
ENSG00000253729 E093 194.1718595 3.627422e-02 1.763722e-04 2.407335e-03 8 47939551 47939697 147 - 2.431 2.026 -1.354
ENSG00000253729 E094 0.0000000       8 47939698 47939950 253 -      
ENSG00000253729 E095 170.3805283 1.636859e+00 9.393749e-01 9.719268e-01 8 47943209 47943366 158 - 2.363 1.999 -1.217
ENSG00000253729 E096 87.7889535 4.294619e-01 5.421213e-01 7.305850e-01 8 47943853 47943883 31 - 2.086 1.692 -1.326
ENSG00000253729 E097 141.6687874 8.679644e-02 1.342348e-02 7.209641e-02 8 47943974 47944029 56 - 2.300 1.875 -1.426
ENSG00000253729 E098 183.6849619 3.545333e-02 3.598364e-05 6.299844e-04 8 47953620 47953719 100 - 2.416 1.977 -1.468
ENSG00000253729 E099 162.2718066 9.227139e-03 2.249253e-18 5.425779e-16 8 47953807 47953919 113 - 2.380 1.866 -1.721
ENSG00000253729 E100 80.9164081 6.918314e-03 6.272352e-22 2.315630e-19 8 47954338 47954349 12 - 2.096 1.499 -2.016
ENSG00000253729 E101 130.8688235 1.275109e-03 1.739416e-43 3.787088e-40 8 47954350 47954446 97 - 2.292 1.758 -1.791
ENSG00000253729 E102 115.1931070 3.494027e-04 3.365967e-48 9.688451e-45 8 47955874 47955948 75 - 2.237 1.692 -1.830
ENSG00000253729 E103 112.7392997 4.017827e-04 2.484510e-43 5.340847e-40 8 47957171 47957263 93 - 2.223 1.705 -1.741
ENSG00000253729 E104 98.3185561 3.424750e-02 6.710241e-06 1.485207e-04 8 47957355 47957431 77 - 2.154 1.685 -1.577
ENSG00000253729 E105 0.1779838 4.460683e-02 6.162145e-01   8 47959115 47959309 195 - 0.112 0.000 -9.575
ENSG00000253729 E106 76.1044413 7.415758e-02 3.263847e-03 2.497743e-02 8 47959973 47960178 206 - 2.034 1.609 -1.436