ENSG00000251580

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000513179 ENSG00000251580 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC02482 lncRNA lncRNA 4.816834 3.864533 3.216193 0.1976329 0.2892201 -0.2641897 1.55465318 0.8426499 1.49347415 0.1192694 0.42100978 0.8182747 0.32832083 0.2221667 0.45120000 0.22903333 0.3652954360 0.0004531523   FALSE
ENST00000515205 ENSG00000251580 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC02482 lncRNA lncRNA 4.816834 3.864533 3.216193 0.1976329 0.2892201 -0.2641897 2.59378222 1.5566955 1.21649123 0.3931673 0.03777554 -0.3531879 0.51651250 0.3949000 0.38213333 -0.01276667 1.0000000000 0.0004531523   FALSE
MSTRG.24531.1 ENSG00000251580 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC02482 lncRNA   4.816834 3.864533 3.216193 0.1976329 0.2892201 -0.2641897 0.25770452 1.1154128 0.04867608 0.1342991 0.04867608 -4.2615380 0.05991250 0.2905667 0.01286667 -0.27770000 0.0004531523 0.0004531523   FALSE
MSTRG.24531.5 ENSG00000251580 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC02482 lncRNA   4.816834 3.864533 3.216193 0.1976329 0.2892201 -0.2641897 0.03178725 0.0000000 0.25429801 0.0000000 0.25429801 4.7240937 0.01117083 0.0000000 0.08936667 0.08936667 0.8547962121 0.0004531523   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000251580 E001 2.1134566 0.009927996 0.051127188 0.18236867 4 6617408 6617435 28 - 0.175 0.547 2.351
ENSG00000251580 E002 0.0000000       4 6648695 6648990 296 -      
ENSG00000251580 E003 0.1308682 0.037605316 1.000000000   4 6652007 6652174 168 - 0.000 0.083 7.696
ENSG00000251580 E004 3.8283917 0.026601243 0.022137069 0.10305610 4 6658107 6659451 1345 - 0.299 0.721 2.108
ENSG00000251580 E005 4.2775404 0.030686434 0.040319787 0.15553043 4 6659452 6659570 119 - 0.395 0.768 1.710
ENSG00000251580 E006 5.8736863 0.004951784 0.001377728 0.01274518 4 6661940 6662036 97 - 0.395 0.900 2.226
ENSG00000251580 E007 2.2920760 0.285378601 0.223251403 0.45725409 4 6669563 6669811 249 - 0.658 0.391 -1.281
ENSG00000251580 E008 1.8069714 0.142224603 0.327724905 0.56681237 4 6669812 6669898 87 - 0.540 0.358 -0.947
ENSG00000251580 E009 1.1777613 0.020243771 0.024937474   4 6669899 6670098 200 - 0.541 0.153 -2.553
ENSG00000251580 E010 2.9693819 0.009106621 0.414384157 0.63936497 4 6670099 6670714 616 - 0.650 0.521 -0.579
ENSG00000251580 E011 0.9338807 0.019142722 0.317179403   4 6670715 6670722 8 - 0.395 0.213 -1.230
ENSG00000251580 E012 0.7311465 0.042163856 0.185176277   4 6670723 6670724 2 - 0.394 0.152 -1.815
ENSG00000251580 E013 0.7311465 0.042163856 0.185176277   4 6670725 6670727 3 - 0.394 0.152 -1.815
ENSG00000251580 E014 17.9239714 0.004188470 0.014560801 0.07647550 4 6670728 6670993 266 - 1.366 1.185 -0.636
ENSG00000251580 E015 6.7219888 0.006508777 0.826759925 0.91190569 4 6670994 6670999 6 - 0.840 0.864 0.091
ENSG00000251580 E016 1.2607059 0.014476496 0.769082223   4 6671430 6671502 73 - 0.299 0.354 0.350
ENSG00000251580 E017 24.9801478 0.009676551 0.496461165 0.69853619 4 6673684 6673965 282 - 1.346 1.389 0.149