ENSG00000249395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000669950 ENSG00000249395 HEK293_OSMI2_6hA HEK293_TMG_6hB CASC9 lncRNA lncRNA 4.773406 4.213907 4.004819 0.6303493 0.1180203 -0.07324293 1.4377808 0.7656722 2.2611984 0.1590157 0.17644960 1.549935 0.31148333 0.179466667 0.56536667 0.3859000 2.717127e-06 1.827889e-06 TRUE FALSE
ENST00000675539 ENSG00000249395 HEK293_OSMI2_6hA HEK293_TMG_6hB CASC9 lncRNA retained_intron 4.773406 4.213907 4.004819 0.6303493 0.1180203 -0.07324293 0.1940672 0.1828567 0.0000000 0.1828567 0.00000000 -4.269457 0.04080833 0.058600000 0.00000000 -0.0586000 8.970853e-01 1.827889e-06   FALSE
ENST00000675897 ENSG00000249395 HEK293_OSMI2_6hA HEK293_TMG_6hB CASC9 lncRNA lncRNA 4.773406 4.213907 4.004819 0.6303493 0.1180203 -0.07324293 0.2002041 0.0161613 0.5958938 0.0161613 0.07551908 4.533559 0.04429583 0.003033333 0.15013333 0.1471000 1.827889e-06 1.827889e-06   FALSE
ENST00000676364 ENSG00000249395 HEK293_OSMI2_6hA HEK293_TMG_6hB CASC9 lncRNA lncRNA 4.773406 4.213907 4.004819 0.6303493 0.1180203 -0.07324293 0.9154566 1.0327293 0.2297181 0.4166296 0.06733319 -2.120954 0.18741667 0.227233333 0.05733333 -0.1699000 9.523194e-02 1.827889e-06   FALSE
MSTRG.31669.15 ENSG00000249395 HEK293_OSMI2_6hA HEK293_TMG_6hB CASC9 lncRNA   4.773406 4.213907 4.004819 0.6303493 0.1180203 -0.07324293 1.7037100 2.0824439 0.7737893 0.3331347 0.21918422 -1.416651 0.34830000 0.497366667 0.19030000 -0.3070667 4.185402e-02 1.827889e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000249395 E001 0.0000000       8 75120409 75120412 4 -      
ENSG00000249395 E002 5.3519541 0.005684288 1.742479e-07 6.103815e-06 8 75120413 75120707 295 - 0.308 1.116 3.544
ENSG00000249395 E003 0.1308682 0.032649190 3.959099e-01   8 75120708 75120798 91 - 0.000 0.147 10.876
ENSG00000249395 E004 3.5543144 0.009650900 6.244636e-03 4.092948e-02 8 75121638 75121756 119 - 0.406 0.894 2.139
ENSG00000249395 E005 0.0000000       8 75223115 75223121 7 -      
ENSG00000249395 E006 0.0000000       8 75223122 75223126 5 -      
ENSG00000249395 E007 0.0000000       8 75223127 75223134 8 -      
ENSG00000249395 E008 9.5424860 0.008958194 4.029835e-02 1.554795e-01 8 75223135 75223317 183 - 1.055 0.917 -0.512
ENSG00000249395 E009 6.9361858 0.083740032 1.680104e-01 3.879394e-01 8 75223318 75223342 25 - 0.933 0.798 -0.521
ENSG00000249395 E010 10.9683298 0.003977256 2.880108e-03 2.268803e-02 8 75223343 75223425 83 - 1.136 0.917 -0.803
ENSG00000249395 E011 8.1576461 0.063331694 3.476419e-02 1.409886e-01 8 75223426 75223452 27 - 1.036 0.768 -1.020
ENSG00000249395 E012 13.1525596 0.017589521 1.141029e-04 1.667581e-03 8 75223453 75223543 91 - 1.244 0.896 -1.268
ENSG00000249395 E013 14.0069549 0.048604123 3.511507e-04 4.251637e-03 8 75223544 75223671 128 - 1.287 0.873 -1.506
ENSG00000249395 E014 36.4106615 0.001694574 1.045169e-12 1.066669e-10 8 75223672 75224358 687 - 1.667 1.357 -1.065
ENSG00000249395 E015 0.0000000       8 75232218 75232249 32 -      
ENSG00000249395 E016 0.0000000       8 75243804 75243835 32 -      
ENSG00000249395 E017 0.1308682 0.032649190 3.959099e-01   8 75271314 75271433 120 - 0.000 0.147 10.876
ENSG00000249395 E018 0.0000000       8 75276987 75277090 104 -      
ENSG00000249395 E019 0.6783511 0.022485727 2.218139e-02   8 75278357 75278481 125 - 0.000 0.417 12.765
ENSG00000249395 E020 0.1723744 0.047647738 3.925642e-01   8 75278482 75278637 156 - 0.000 0.147 10.849
ENSG00000249395 E021 0.0000000       8 75278713 75278924 212 -      
ENSG00000249395 E022 16.3402532 0.028905097 1.557355e-09 8.751647e-08 8 75313420 75313735 316 - 0.752 1.533 2.829
ENSG00000249395 E023 24.1307758 0.258329617 3.884917e-02 1.517430e-01 8 75324221 75324333 113 - 1.130 1.621 1.708
ENSG00000249395 E024 18.8833577 0.064117602 2.457555e-02 1.109234e-01 8 75324334 75324564 231 - 1.104 1.489 1.349
ENSG00000249395 E025 10.3942883 0.008894568 6.573673e-02 2.156011e-01 8 75324565 75324785 221 - 0.928 1.210 1.026
ENSG00000249395 E026 0.0000000       8 75344104 75344185 82 -      
ENSG00000249395 E027 0.0000000       8 75351873 75352026 154 -      
ENSG00000249395 E028 0.0000000       8 75352166 75352327 162 -