ENSG00000249115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000203166 ENSG00000249115 HEK293_OSMI2_6hA HEK293_TMG_6hB HAUS5 protein_coding protein_coding 20.20115 26.33844 16.58212 3.02842 0.9699151 -0.6672196 7.593634 12.185908 3.584049 3.0393711 0.3473715 -1.76271515 0.37247917 0.49113333 0.21740000 -0.27373333 0.42221038 0.01201234 FALSE TRUE
ENST00000430749 ENSG00000249115 HEK293_OSMI2_6hA HEK293_TMG_6hB HAUS5 protein_coding retained_intron 20.20115 26.33844 16.58212 3.02842 0.9699151 -0.6672196 1.673697 2.216784 2.098940 0.8424359 0.4429127 -0.07844353 0.07942083 0.07846667 0.12583333 0.04736667 0.73191785 0.01201234   FALSE
ENST00000585968 ENSG00000249115 HEK293_OSMI2_6hA HEK293_TMG_6hB HAUS5 protein_coding retained_intron 20.20115 26.33844 16.58212 3.02842 0.9699151 -0.6672196 6.316477 7.817786 5.709090 2.7333039 0.7066799 -0.45281878 0.30798750 0.28343333 0.34846667 0.06503333 0.85285419 0.01201234 TRUE TRUE
ENST00000588570 ENSG00000249115 HEK293_OSMI2_6hA HEK293_TMG_6hB HAUS5 protein_coding retained_intron 20.20115 26.33844 16.58212 3.02842 0.9699151 -0.6672196 1.178352 1.081874 2.110641 0.4149008 0.0802269 0.95769465 0.06242083 0.03920000 0.12780000 0.08860000 0.01201234 0.01201234   FALSE
ENST00000592291 ENSG00000249115 HEK293_OSMI2_6hA HEK293_TMG_6hB HAUS5 protein_coding nonsense_mediated_decay 20.20115 26.33844 16.58212 3.02842 0.9699151 -0.6672196 1.698018 1.088918 1.642266 0.8450517 0.9169944 0.58836189 0.09121250 0.03613333 0.09343333 0.05730000 0.89082672 0.01201234 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000249115 E001 1.284836 3.0041478252 8.573062e-01   19 35612735 35612743 9 + 0.001 0.358 9.776
ENSG00000249115 E002 9.158887 0.0036843088 1.000000e+00 1.000000e+00 19 35612744 35612751 8 + 0.906 0.935 0.111
ENSG00000249115 E003 11.225108 0.0029966935 1.000000e+00 1.000000e+00 19 35612752 35612762 11 + 0.970 1.011 0.150
ENSG00000249115 E004 23.773003 0.0100020274 6.849252e-01 8.258755e-01 19 35612763 35612770 8 + 1.275 1.314 0.134
ENSG00000249115 E005 62.136156 0.0025862078 1.285607e-01 3.295830e-01 19 35612771 35612799 29 + 1.642 1.729 0.294
ENSG00000249115 E006 107.454119 0.0006474701 5.002241e-03 3.464077e-02 19 35612800 35612892 93 + 1.846 1.964 0.397
ENSG00000249115 E007 6.160277 0.0546209057 1.044161e-01 2.896007e-01 19 35613669 35613729 61 + 0.966 0.708 -1.006
ENSG00000249115 E008 117.743735 0.0004473877 7.959331e-01 8.939772e-01 19 35613730 35613792 63 + 1.982 1.983 0.006
ENSG00000249115 E009 14.502634 0.0024264152 2.004045e-07 6.903303e-06 19 35613793 35613867 75 + 1.446 0.967 -1.702
ENSG00000249115 E010 112.351338 0.0004560094 5.746300e-01 7.534039e-01 19 35613868 35613900 33 + 1.987 1.955 -0.107
ENSG00000249115 E011 14.258232 0.3847156431 2.057479e-01 4.367536e-01 19 35613901 35614034 134 + 1.278 1.030 -0.888
ENSG00000249115 E012 108.679609 0.0026676288 3.889004e-01 6.196228e-01 19 35614035 35614059 25 + 1.988 1.936 -0.174
ENSG00000249115 E013 10.164305 0.0587955275 1.970877e-02 9.492082e-02 19 35614060 35614231 172 + 1.222 0.868 -1.298
ENSG00000249115 E014 184.828464 0.0003965147 9.955165e-02 2.809452e-01 19 35615042 35615147 106 + 2.226 2.164 -0.206
ENSG00000249115 E015 214.520141 0.0002516332 6.728937e-01 8.181689e-01 19 35615227 35615386 160 + 2.259 2.238 -0.072
ENSG00000249115 E016 127.150344 0.0004882787 3.320928e-01 5.709585e-01 19 35617124 35617193 70 + 1.996 2.026 0.101
ENSG00000249115 E017 142.790233 0.0003386670 8.068228e-01 9.002423e-01 19 35617287 35617369 83 + 2.068 2.068 0.001
ENSG00000249115 E018 132.203446 0.0003764342 6.600749e-01 8.100293e-01 19 35617855 35617912 58 + 2.026 2.034 0.027
ENSG00000249115 E019 186.332784 0.0003971614 3.651294e-01 6.000617e-01 19 35618071 35618195 125 + 2.162 2.183 0.071
ENSG00000249115 E020 130.821364 0.0003479528 4.429275e-01 6.607049e-01 19 35618402 35618465 64 + 2.012 2.033 0.070
ENSG00000249115 E021 191.839103 0.0002532559 2.644661e-01 5.036946e-01 19 35618569 35618699 131 + 2.171 2.198 0.089
ENSG00000249115 E022 184.430887 0.0003496035 1.555277e-01 3.701943e-01 19 35618887 35619049 163 + 2.148 2.186 0.128
ENSG00000249115 E023 122.172994 0.0023577946 1.210685e-01 3.175654e-01 19 35619424 35619504 81 + 1.947 2.012 0.219
ENSG00000249115 E024 169.906071 0.0031479574 4.355580e-01 6.554114e-01 19 35619613 35619758 146 + 2.118 2.146 0.094
ENSG00000249115 E025 76.997039 0.0881293057 4.206707e-01 6.441826e-01 19 35619759 35619943 185 + 1.842 1.784 -0.194
ENSG00000249115 E026 46.121399 0.0905183110 5.015821e-01 7.019472e-01 19 35619944 35620011 68 + 1.619 1.569 -0.169
ENSG00000249115 E027 94.289297 0.0004994408 3.620208e-02 1.447734e-01 19 35620012 35620057 46 + 1.814 1.905 0.307
ENSG00000249115 E028 112.310400 0.0004164012 9.583488e-01 9.810573e-01 19 35620058 35620123 66 + 1.970 1.965 -0.017
ENSG00000249115 E029 8.169077 0.0627933088 8.079166e-03 4.968416e-02 19 35620124 35620194 71 + 1.174 0.767 -1.526
ENSG00000249115 E030 187.096244 0.0033147912 5.380053e-01 7.276481e-01 19 35620195 35620327 133 + 2.162 2.188 0.087
ENSG00000249115 E031 189.913578 0.0041835369 8.160478e-01 9.058749e-01 19 35622601 35622733 133 + 2.183 2.192 0.029
ENSG00000249115 E032 186.033468 0.0029808428 6.409906e-01 7.975131e-01 19 35622876 35623057 182 + 2.170 2.182 0.043
ENSG00000249115 E033 632.801584 0.0018385969 1.576360e-02 8.096505e-02 19 35623058 35625355 2298 + 2.755 2.695 -0.201