ENSG00000249069

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000512618 ENSG00000249069 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01033 lncRNA lncRNA 4.385412 3.011575 2.122899 0.9732799 0.5132125 -0.5024848 0.969251 1.2399039 0.000000 0.3791919 0.00000000 -6.9656733 0.1955500 0.4363333 0.0000000 -0.4363333 1.773228e-10 1.773228e-10   FALSE
ENST00000657274 ENSG00000249069 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01033 lncRNA lncRNA 4.385412 3.011575 2.122899 0.9732799 0.5132125 -0.5024848 1.347770 0.9276804 1.001335 0.3514783 0.04454351 0.1090934 0.3639708 0.2865667 0.5671667 0.2806000 6.896192e-01 1.773228e-10   FALSE
MSTRG.26184.16 ENSG00000249069 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01033 lncRNA   4.385412 3.011575 2.122899 0.9732799 0.5132125 -0.5024848 1.818882 0.6748439 1.019933 0.2720898 0.52149168 0.5887032 0.3737208 0.2080667 0.3861333 0.1780667 8.996145e-01 1.773228e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000249069 E001 0.0000000       5 54313564 54313567 4 +      
ENSG00000249069 E002 0.0000000       5 54313568 54313593 26 +      
ENSG00000249069 E003 0.0000000       5 54313594 54313595 2 +      
ENSG00000249069 E004 0.0000000       5 54313596 54313602 7 +      
ENSG00000249069 E005 0.0000000       5 54313603 54313618 16 +      
ENSG00000249069 E006 0.0000000       5 54313619 54313623 5 +      
ENSG00000249069 E007 0.0000000       5 54313624 54313625 2 +      
ENSG00000249069 E008 0.0000000       5 54313626 54313656 31 +      
ENSG00000249069 E009 0.0000000       5 54313657 54313658 2 +      
ENSG00000249069 E010 0.0000000       5 54313659 54313750 92 +      
ENSG00000249069 E011 0.2027342 0.036824890 0.76294585   5 54317552 54317788 237 + 0.000 0.099 8.767
ENSG00000249069 E012 0.0000000       5 54320912 54320913 2 +      
ENSG00000249069 E013 0.1426347 0.034449258 0.30947961   5 54320914 54320998 85 + 0.149 0.000 -12.448
ENSG00000249069 E014 0.0000000       5 54322881 54322923 43 +      
ENSG00000249069 E015 0.0000000       5 54340193 54340309 117 +      
ENSG00000249069 E016 1.9129582 0.011824425 0.42237032 0.6454150 5 54390785 54390837 53 + 0.538 0.402 -0.687
ENSG00000249069 E017 1.9129582 0.011824425 0.42237032 0.6454150 5 54390838 54390840 3 + 0.538 0.402 -0.687
ENSG00000249069 E018 2.5913093 0.009038382 0.92671722 0.9654366 5 54390841 54390850 10 + 0.539 0.549 0.050
ENSG00000249069 E019 13.0715322 0.003003116 0.59377938 0.7662189 5 54390851 54390933 83 + 1.110 1.153 0.154
ENSG00000249069 E020 0.8265952 0.019387492 0.94430526   5 54395349 54395350 2 + 0.260 0.246 -0.103
ENSG00000249069 E021 1.5768124 0.104884777 0.33726294 0.5756398 5 54395351 54395417 67 + 0.260 0.450 1.148
ENSG00000249069 E022 11.3424570 0.005004688 0.24165184 0.4784504 5 54396997 54397134 138 + 1.001 1.112 0.407
ENSG00000249069 E023 0.1614157 0.033486653 0.30950548   5 54400437 54400532 96 + 0.149 0.000 -12.450
ENSG00000249069 E024 0.0000000       5 54400533 54400598 66 +      
ENSG00000249069 E025 3.4183141 0.007558046 0.01364683 0.0729568 5 54401643 54401865 223 + 0.348 0.746 1.896
ENSG00000249069 E026 1.0592568 0.426195743 0.87856811   5 54401866 54402756 891 + 0.263 0.314 0.350
ENSG00000249069 E027 1.1320506 0.021534893 0.57695024   5 54402757 54403522 766 + 0.260 0.356 0.632
ENSG00000249069 E028 1.1024985 0.134432384 0.45235997   5 54403523 54403788 266 + 0.421 0.246 -1.104
ENSG00000249069 E029 10.6523435 0.004655810 0.04014086 0.1550656 5 54408455 54408521 67 + 1.173 0.983 -0.689
ENSG00000249069 E030 6.3136442 0.005731987 0.58501907 0.7603273 5 54415022 54415238 217 + 0.901 0.835 -0.254