ENSG00000248092

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000513560 ENSG00000248092 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.078057 2.333453 3.680889 0.3157251 0.06730135 0.6553325 1.323822 0.5520259 2.338795 0.04482086 0.0429061 2.0632121 0.3940125 0.2398 0.6355333 0.3957333 8.436127e-08 8.436127e-08   FALSE
ENST00000606697 ENSG00000248092 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 3.078057 2.333453 3.680889 0.3157251 0.06730135 0.6553325 1.382433 1.5586930 1.023398 0.25643622 0.1253970 -0.6021668 0.4987333 0.6630 0.2788667 -0.3841333 6.214676e-05 8.436127e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000248092 E001 2.8939699 0.008049555 6.434495e-01 0.799149897 5 43571594 43571828 235 - 0.582 0.487 -0.447
ENSG00000248092 E002 9.0377601 0.003555954 4.679466e-01 0.678685271 5 43571829 43571997 169 - 0.994 0.887 -0.399
ENSG00000248092 E003 37.9353075 0.001154453 3.535530e-01 0.590476520 5 43571998 43572779 782 - 1.573 1.498 -0.258
ENSG00000248092 E004 10.2891726 0.003525275 8.678951e-01 0.934826932 5 43572780 43572911 132 - 1.028 0.990 -0.139
ENSG00000248092 E005 101.9081046 0.038294616 7.640298e-02 0.237532633 5 43572912 43575563 2652 - 2.003 1.870 -0.447
ENSG00000248092 E006 12.5534278 0.002496666 8.787415e-01 0.940652197 5 43575564 43575777 214 - 1.096 1.092 -0.015
ENSG00000248092 E007 12.2547514 0.019598337 7.665408e-01 0.876531047 5 43575778 43575935 158 - 1.108 1.051 -0.204
ENSG00000248092 E008 4.9693463 0.006744510 8.741871e-06 0.000186809 5 43577642 43578268 627 - 0.479 1.055 2.361
ENSG00000248092 E009 4.5854059 0.008919575 4.909486e-02 0.177432464 5 43578269 43578579 311 - 0.626 0.887 1.055
ENSG00000248092 E010 4.2075733 0.006676410 9.785201e-02 0.278043053 5 43578580 43579129 550 - 0.604 0.825 0.913
ENSG00000248092 E011 0.7448680 0.316901666 4.141291e-01   5 43579130 43579200 71 - 0.148 0.317 1.401
ENSG00000248092 E012 10.3402482 0.096776420 1.121867e-01 0.302757562 5 43583467 43583566 100 - 0.949 1.158 0.762
ENSG00000248092 E013 0.2027342 0.055926801 1.735699e-01   5 43588234 43588640 407 - 0.000 0.182 11.461
ENSG00000248092 E014 0.3032425 0.024441170 4.237726e-02   5 43588641 43588766 126 - 0.000 0.308 12.470
ENSG00000248092 E015 16.4243004 0.565407435 4.058988e-01 0.632980525 5 43602778 43603230 453 - 1.161 1.288 0.448