ENSG00000247828

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000496733 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA lncRNA 7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.4155779 0.1951683 0.8230925 0.13987136 0.09285198 2.02166908 0.05138750 0.04000000 0.08386667 0.04386667 6.025686e-01 1.173148e-05    
ENST00000666808 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA lncRNA 7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.1841769 0.2586580 0.0000000 0.05783348 0.00000000 -4.74769880 0.02736250 0.05303333 0.00000000 -0.05303333 1.173148e-05 1.173148e-05    
ENST00000668128 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA lncRNA 7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.5872795 0.4233583 0.6386689 0.18776225 0.07539025 0.58192194 0.07693750 0.08663333 0.06540000 -0.02123333 9.547299e-01 1.173148e-05    
MSTRG.26548.11 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA   7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.5509350 0.4114268 0.9025353 0.06578333 0.20694317 1.11459841 0.07464583 0.08440000 0.09210000 0.00770000 9.793706e-01 1.173148e-05    
MSTRG.26548.26 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA   7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.8211728 0.7663360 0.8655646 0.15809951 0.15487766 0.17353232 0.11338750 0.15753333 0.08886667 -0.06866667 5.586172e-01 1.173148e-05    
MSTRG.26548.28 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA   7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 2.3227875 1.4720825 3.1256313 0.24689971 0.55077448 1.08113017 0.31607500 0.30220000 0.31830000 0.01610000 9.833980e-01 1.173148e-05    
MSTRG.26548.62 ENSG00000247828 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM161B-DT lncRNA   7.432355 4.872053 9.788686 0.02577394 0.1433008 1.0051 0.4160350 0.3232507 0.3397592 0.04771155 0.18961053 0.06975403 0.05685417 0.06636667 0.03513333 -0.03123333 7.258384e-01 1.173148e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000247828 E001 0.0000000       5 88268868 88268870 3 +      
ENSG00000247828 E002 0.3336024 0.027442404 1.339422e-01   5 88268871 88268890 20 + 0.000 0.231 13.353
ENSG00000247828 E003 0.4644705 0.025153631 4.916986e-02   5 88268891 88268894 4 + 0.000 0.311 13.959
ENSG00000247828 E004 0.7497398 0.044467440 4.463226e-01   5 88268895 88268898 4 + 0.202 0.311 0.821
ENSG00000247828 E005 2.2384485 0.250234285 7.795042e-01 0.884456691 5 88268899 88268914 16 + 0.519 0.529 0.043
ENSG00000247828 E006 2.3998642 0.210202428 9.128877e-01 0.958556913 5 88268915 88268916 2 + 0.557 0.530 -0.129
ENSG00000247828 E007 2.3998642 0.210202428 9.128877e-01 0.958556913 5 88268917 88268917 1 + 0.557 0.530 -0.129
ENSG00000247828 E008 3.0596219 0.025539498 5.165219e-01 0.712669515 5 88268918 88268922 5 + 0.597 0.652 0.240
ENSG00000247828 E009 2.9169872 0.011663234 3.921804e-01 0.622144075 5 88268923 88268928 6 + 0.565 0.653 0.389
ENSG00000247828 E010 3.2092711 0.014978754 3.874453e-01 0.618447717 5 88268929 88268930 2 + 0.598 0.685 0.373
ENSG00000247828 E011 3.5546400 0.016020469 3.731228e-01 0.606622310 5 88268931 88268932 2 + 0.629 0.715 0.364
ENSG00000247828 E012 8.0828157 0.146288009 4.849587e-01 0.690533282 5 88268933 88268976 44 + 0.944 0.978 0.125
ENSG00000247828 E013 9.0245187 0.195299955 5.346378e-01 0.725415123 5 88268977 88268986 10 + 0.996 1.010 0.051
ENSG00000247828 E014 9.5046999 0.204544751 4.576232e-01 0.671523322 5 88268987 88268994 8 + 1.005 1.041 0.133
ENSG00000247828 E015 9.1890707 0.166034541 4.006616e-01 0.628819154 5 88268995 88268995 1 + 0.982 1.039 0.210
ENSG00000247828 E016 10.8509616 0.245407197 5.158631e-01 0.712163961 5 88268996 88269009 14 + 1.072 1.079 0.024
ENSG00000247828 E017 10.9414210 0.262560092 4.752096e-01 0.683683928 5 88269010 88269014 5 + 1.062 1.095 0.121
ENSG00000247828 E018 10.3231695 0.292991434 5.726922e-01 0.752169804 5 88269015 88269015 1 + 1.051 1.058 0.024
ENSG00000247828 E019 10.8181876 0.312684476 5.448623e-01 0.732546491 5 88269016 88269018 3 + 1.062 1.084 0.080
ENSG00000247828 E020 11.3353106 0.260043182 4.220020e-01 0.645151868 5 88269019 88269023 5 + 1.063 1.122 0.212
ENSG00000247828 E021 11.3353106 0.260043182 4.220020e-01 0.645151868 5 88269024 88269027 4 + 1.063 1.122 0.212
ENSG00000247828 E022 0.7491197 0.017562111 9.287098e-02   5 88269028 88269032 5 + 0.113 0.380 2.234
ENSG00000247828 E023 0.7491197 0.017562111 9.287098e-02   5 88269033 88269033 1 + 0.113 0.380 2.234
ENSG00000247828 E024 1.5709132 0.012198908 2.781806e-01 0.518305434 5 88269034 88269035 2 + 0.340 0.491 0.823
ENSG00000247828 E025 3.0361909 0.009127618 1.604397e-03 0.014360589 5 88269036 88269037 2 + 0.340 0.796 2.143
ENSG00000247828 E026 3.0361909 0.009127618 1.604397e-03 0.014360589 5 88269038 88269038 1 + 0.340 0.796 2.143
ENSG00000247828 E027 4.3924158 0.023062347 3.764575e-04 0.004501242 5 88269039 88269041 3 + 0.444 0.938 2.111
ENSG00000247828 E028 6.6744635 0.078330046 5.238143e-02 0.185200948 5 88269042 88269046 5 + 0.753 1.006 0.971
ENSG00000247828 E029 9.4007727 0.123021673 5.644596e-02 0.194695295 5 88269047 88269049 3 + 0.882 1.138 0.946
ENSG00000247828 E030 12.7598806 0.186274991 1.168561e-01 0.310580474 5 88269050 88269063 14 + 1.030 1.242 0.760
ENSG00000247828 E031 16.5665131 0.076440263 6.708537e-02 0.218597350 5 88269064 88269072 9 + 1.148 1.338 0.668
ENSG00000247828 E032 17.3453725 0.067667564 3.374116e-02 0.138176107 5 88269073 88269075 3 + 1.149 1.370 0.780
ENSG00000247828 E033 17.5177469 0.064059704 2.767004e-02 0.120299324 5 88269076 88269077 2 + 1.149 1.377 0.803
ENSG00000247828 E034 29.3057364 0.002401594 3.572585e-03 0.026774367 5 88269078 88269119 42 + 1.419 1.552 0.459
ENSG00000247828 E035 4.9653882 0.098241633 4.984913e-01 0.699759844 5 88269468 88269617 150 + 0.847 0.680 -0.670
ENSG00000247828 E036 4.0921210 0.130090786 1.323813e-01 0.335563213 5 88269618 88269687 70 + 0.829 0.490 -1.456
ENSG00000247828 E037 16.3809438 0.011346915 6.957074e-02 0.223905972 5 88269688 88270499 812 + 1.326 1.101 -0.798
ENSG00000247828 E038 0.9335208 0.016389616 1.776830e-01   5 88270500 88270525 26 + 0.396 0.130 -2.088
ENSG00000247828 E039 59.4874991 0.007456128 4.603556e-02 0.170128112 5 88270526 88270585 60 + 1.757 1.816 0.202
ENSG00000247828 E040 6.0949389 0.004468975 8.800422e-02 0.260024028 5 88270586 88270741 156 + 0.955 0.686 -1.058
ENSG00000247828 E041 51.6918045 0.079981808 1.963122e-05 0.000376534 5 88270742 88275910 5169 + 1.915 1.266 -2.219
ENSG00000247828 E042 86.2369972 0.110480142 1.495659e-02 0.077925244 5 88275911 88281072 5162 + 2.071 1.712 -1.206
ENSG00000247828 E043 4.7836984 0.005352658 4.330673e-01 0.653520459 5 88281073 88281143 71 + 0.737 0.796 0.236
ENSG00000247828 E044 5.0909731 0.009262689 3.443204e-01 0.581923796 5 88281144 88281197 54 + 0.860 0.685 -0.700
ENSG00000247828 E045 17.7976660 0.073209553 9.289179e-01 0.966494603 5 88281198 88281850 653 + 1.283 1.257 -0.093
ENSG00000247828 E046 7.7851863 0.127985850 6.094843e-01 0.776564678 5 88281851 88282041 191 + 0.981 0.891 -0.337
ENSG00000247828 E047 28.9686881 0.001617404 2.071670e-03 0.017545246 5 88282042 88282106 65 + 1.409 1.552 0.490
ENSG00000247828 E048 8.1691182 0.004054343 9.617529e-01 0.982889664 5 88282107 88282602 496 + 0.983 0.939 -0.164
ENSG00000247828 E049 5.0529649 0.007039438 2.416827e-01 0.478478653 5 88282603 88282714 112 + 0.860 0.653 -0.835
ENSG00000247828 E050 13.1403199 0.003122130 7.105299e-02 0.226833963 5 88282715 88282719 5 + 1.100 1.214 0.408
ENSG00000247828 E051 17.3359544 0.003866344 2.552115e-01 0.493810774 5 88282720 88282756 37 + 1.247 1.290 0.153
ENSG00000247828 E052 33.2397547 0.001490881 2.182836e-01 0.451376034 5 88282757 88282866 110 + 1.528 1.548 0.069
ENSG00000247828 E053 3.0500092 0.330266935 8.020370e-01 0.897529561 5 88282867 88283009 143 + 0.604 0.594 -0.046
ENSG00000247828 E054 7.4575581 0.004076871 9.806584e-01 0.992096966 5 88283010 88283086 77 + 0.955 0.903 -0.197
ENSG00000247828 E055 22.5752051 0.007977944 1.902798e-01 0.417298000 5 88283087 88285740 2654 + 1.439 1.283 -0.542
ENSG00000247828 E056 4.8103018 0.005669193 6.743499e-01 0.819112297 5 88285741 88285743 3 + 0.760 0.771 0.042
ENSG00000247828 E057 21.2967849 0.001947845 6.841196e-01 0.825365274 5 88285744 88285851 108 + 1.383 1.299 -0.293
ENSG00000247828 E058 27.9757197 0.066332699 4.415647e-01 0.659788357 5 88285852 88287435 1584 + 1.509 1.395 -0.393
ENSG00000247828 E059 17.3059005 0.003912072 2.078628e-01 0.439235243 5 88287436 88287438 3 + 1.239 1.291 0.184
ENSG00000247828 E060 31.9954151 0.010857606 2.253782e-01 0.459785727 5 88287439 88287622 184 + 1.499 1.543 0.151
ENSG00000247828 E061 9.3095362 0.032955514 8.034657e-01 0.898298773 5 88287623 88290200 2578 + 1.036 0.962 -0.273
ENSG00000247828 E062 1.7351780 0.259179469 7.349285e-01 0.857207111 5 88291384 88291476 93 + 0.491 0.374 -0.619
ENSG00000247828 E063 3.2841739 0.007925302 6.725396e-01 0.817917938 5 88291477 88291804 328 + 0.687 0.579 -0.466
ENSG00000247828 E064 3.3020272 0.007603732 4.902507e-01 0.694164839 5 88291805 88292567 763 + 0.687 0.538 -0.656
ENSG00000247828 E065 1.3251976 0.040944109 7.687045e-01   5 88292568 88292643 76 + 0.396 0.312 -0.502
ENSG00000247828 E066 6.3700683 0.134621031 1.417140e-02 0.075024950 5 88292644 88296332 3689 + 1.043 0.487 -2.276
ENSG00000247828 E067 0.5008152 0.066790121 1.457220e-01   5 88319650 88319834 185 + 0.278 0.000 -13.529
ENSG00000247828 E068 0.1723744 0.032609843 3.724188e-01   5 88321694 88323471 1778 + 0.000 0.130 12.378
ENSG00000247828 E069 0.3040503 0.024441170 2.928689e-01   5 88346894 88348601 1708 + 0.203 0.000 -12.939
ENSG00000247828 E070 0.0000000       5 88392181 88392194 14 +      
ENSG00000247828 E071 0.0000000       5 88392195 88392342 148 +      
ENSG00000247828 E072 0.0000000       5 88408981 88409291 311 +      
ENSG00000247828 E073 0.7282998 0.631583379 8.218048e-01   5 88409292 88410072 781 + 0.204 0.243 0.328
ENSG00000247828 E074 17.1299186 0.051052501 3.036438e-01 0.544217624 5 88410073 88410194 122 + 1.331 1.146 -0.651
ENSG00000247828 E075 0.6953672 0.397934058 1.418696e-01   5 88417187 88417491 305 + 0.348 0.000 -13.985
ENSG00000247828 E076 0.1426347 0.030727040 6.304309e-01   5 88424428 88424548 121 + 0.113 0.000 -11.938
ENSG00000247828 E077 0.1426347 0.030727040 6.304309e-01   5 88426641 88426801 161 + 0.113 0.000 -11.938
ENSG00000247828 E078 0.1779838 0.044734443 6.279979e-01   5 88426802 88427376 575 + 0.113 0.000 -11.942
ENSG00000247828 E079 53.8626758 0.060889131 6.275509e-01 0.788922412 5 88436273 88436537 265 + 1.777 1.686 -0.308
ENSG00000247828 E080 15.1908756 0.062355218 6.392083e-01 0.796369125 5 88436538 88439337 2800 + 1.250 1.141 -0.385
ENSG00000247828 E081 0.1779838 0.044734443 6.279979e-01   5 88446528 88446568 41 + 0.113 0.000 -11.942