ENSG00000246090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000499178 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.002545755 0.02036604 0.00000000 0.02036604 0.00000000 -1.6024586 0.006316667 0.05053333 0.00000000 -0.05053333 0.76908832 0.00832936   FALSE
ENST00000500358 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.032332856 0.03702413 0.02110724 0.03050051 0.02110724 -0.5961509 0.083970833 0.10426667 0.04343333 -0.06083333 0.94038959 0.00832936   FALSE
ENST00000506160 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.013551248 0.02915422 0.07925576 0.02915422 0.03979440 1.1887775 0.028766667 0.07523333 0.15490000 0.07966667 0.89776968 0.00832936   FALSE
ENST00000661393 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.058368569 0.02543822 0.06162924 0.01620321 0.04868104 1.0152426 0.137450000 0.06493333 0.11516667 0.05023333 0.97818495 0.00832936   FALSE
ENST00000670724 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.056192966 0.04354581 0.03871157 0.04354581 0.02177182 -0.1365094 0.131241667 0.10803333 0.07270000 -0.03533333 0.97636976 0.00832936   FALSE
ENST00000671105 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.040594834 0.13512616 0.00000000 0.01523745 0.00000000 -3.8592357 0.112508333 0.44376667 0.00000000 -0.44376667 0.00832936 0.00832936   FALSE
ENST00000685116 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.097647007 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.238579167 0.00000000 0.00000000 0.00000000   0.00832936   FALSE
ENST00000687735 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.077042129 0.00000000 0.29547519 0.00000000 0.09738509 4.9329833 0.153087500 0.00000000 0.57726667 0.57726667 0.02444031 0.00832936   FALSE
ENST00000691990 ENSG00000246090 HEK293_OSMI2_6hA HEK293_TMG_6hB lncRNA lncRNA 0.425431 0.337515 0.5157707 0.05798262 0.01526437 0.5973583 0.019666638 0.01827926 0.00000000 0.01827926 0.00000000 -1.4997443 0.051562500 0.08236667 0.00000000 -0.08236667 0.85642984 0.00832936   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000246090 E001 0.0000000       4 99088805 99088832 28 +      
ENSG00000246090 E002 0.0000000       4 99088833 99088834 2 +      
ENSG00000246090 E003 0.1779838 0.104841808 0.549865428   4 99088835 99088838 4 + 0.118 0.000 -10.312
ENSG00000246090 E004 0.1779838 0.104841808 0.549865428   4 99088839 99088856 18 + 0.118 0.000 -12.629
ENSG00000246090 E005 0.1779838 0.104841808 0.549865428   4 99088857 99088859 3 + 0.118 0.000 -12.629
ENSG00000246090 E006 0.8981014 0.480538351 0.405456071   4 99088860 99088950 91 + 0.360 0.129 -1.908
ENSG00000246090 E007 2.4341134 0.010091916 0.016096114 0.08215588 4 99088951 99089072 122 + 0.676 0.301 -1.903
ENSG00000246090 E008 3.4106157 0.008328598 0.027055381 0.11847621 4 99089073 99089284 212 + 0.777 0.477 -1.318
ENSG00000246090 E009 0.1723744 0.036133843 0.453189186   4 99102363 99102380 18 + 0.000 0.125 11.927
ENSG00000246090 E010 1.7207501 0.016550585 0.730724748 0.85463088 4 99102381 99102665 285 + 0.408 0.477 0.361
ENSG00000246090 E011 0.9400874 0.017271634 0.006627207   4 99102666 99102767 102 + 0.000 0.477 13.903
ENSG00000246090 E012 1.7643541 0.028961149 0.830124343 0.91383927 4 99102768 99103120 353 + 0.458 0.426 -0.169
ENSG00000246090 E013 0.9293164 0.019540442 0.394532742   4 99133555 99133805 251 + 0.211 0.368 1.094
ENSG00000246090 E014 0.1614157 0.040774689 0.544149722   4 99154545 99154553 9 + 0.118 0.000 -12.646
ENSG00000246090 E015 6.1319057 0.008538936 0.045648327 0.16913505 4 99154554 99157490 2937 + 0.730 0.969 0.929
ENSG00000246090 E016 1.1848460 0.017267182 0.498620379   4 99157491 99157579 89 + 0.408 0.301 -0.640
ENSG00000246090 E017 0.0000000       4 99161784 99161809 26 +      
ENSG00000246090 E018 0.0000000       4 99161810 99161904 95 +      
ENSG00000246090 E019 0.1308682 0.033630160 0.453616703   4 99188645 99188855 211 + 0.000 0.125 11.924
ENSG00000246090 E020 1.0234303 0.022877530 0.729822417   4 99204357 99204427 71 + 0.351 0.301 -0.318
ENSG00000246090 E021 0.4043710 0.047884867 0.558352458   4 99204428 99204431 4 + 0.118 0.221 1.090
ENSG00000246090 E022 0.0000000       4 99252835 99253132 298 +      
ENSG00000246090 E023 0.0000000       4 99253920 99253928 9 +      
ENSG00000246090 E024 0.0000000       4 99253929 99254063 135 +      
ENSG00000246090 E025 0.0000000       4 99254374 99254439 66 +      
ENSG00000246090 E026 0.3447487 0.189222592 0.224305927   4 99263502 99263810 309 + 0.000 0.224 12.668
ENSG00000246090 E027 0.0000000       4 99267057 99267105 49 +      
ENSG00000246090 E028 0.0000000       4 99267564 99267670 107 +      
ENSG00000246090 E029 0.0000000       4 99267671 99267764 94 +      
ENSG00000246090 E030 0.0000000       4 99267765 99267836 72 +      
ENSG00000246090 E031 0.0000000       4 99274125 99274255 131 +      
ENSG00000246090 E032 0.0000000       4 99274962 99275051 90 +      
ENSG00000246090 E033 0.1426347 0.044428371 0.544058025   4 99278453 99278509 57 + 0.118 0.000 -12.644
ENSG00000246090 E034 0.0000000       4 99281182 99281241 60 +      
ENSG00000246090 E035 0.8993890 0.024354128 0.392140453   4 99286795 99287033 239 + 0.210 0.367 1.093
ENSG00000246090 E036 0.9408952 0.017397871 0.387885199   4 99288666 99288785 120 + 0.210 0.368 1.097
ENSG00000246090 E037 0.0000000       4 99290936 99290936 1 +      
ENSG00000246090 E038 0.0000000       4 99290937 99290948 12 +      
ENSG00000246090 E039 0.3337900 0.028561147 1.000000000   4 99290949 99291005 57 + 0.118 0.125 0.098
ENSG00000246090 E040 0.3337900 0.028561147 1.000000000   4 99300299 99300370 72 + 0.118 0.125 0.098
ENSG00000246090 E041 0.1779838 0.104841808 0.549865428   4 99300469 99300655 187 + 0.118 0.000 -12.629
ENSG00000246090 E042 0.5115862 0.028031862 0.542948839   4 99300951 99301356 406 + 0.118 0.222 1.096