ENSG00000245958

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000500559 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.0989550 0.32172458 0.0000000 0.07417913 0.00000000 -5.0519140 0.01703750 0.06300000 0.00000000 -0.0630000000 7.018267e-06 7.018267e-06   FALSE
ENST00000503038 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene retained_intron 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.6297551 0.73243125 0.6336478 0.02832529 0.08184262 -0.2059860 0.08532500 0.13963333 0.05830000 -0.0813333333 2.908206e-02 7.018267e-06   FALSE
ENST00000511823 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.1366164 0.00000000 0.5746448 0.00000000 0.57464477 5.8694884 0.01128333 0.00000000 0.05053333 0.0505333333 9.539625e-01 7.018267e-06   FALSE
ENST00000686002 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.9827757 0.80694790 0.8802942 0.10022840 0.51212835 0.1240381 0.13391667 0.15513333 0.08876667 -0.0663666667 7.652805e-01 7.018267e-06   FALSE
ENST00000688315 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 1.0242582 0.87729402 1.7637127 0.17971103 0.28638336 0.9992882 0.12791667 0.16890000 0.16813333 -0.0007666667 1.000000e+00 7.018267e-06   FALSE
ENST00000688857 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.7307346 0.02943231 1.7123200 0.02943231 0.39542697 5.4488312 0.08059583 0.00520000 0.15620000 0.1510000000 3.950603e-05 7.018267e-06   FALSE
ENST00000692067 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.4597879 0.11946453 0.7390424 0.08146729 0.37652401 2.5324905 0.05668750 0.02253333 0.06996667 0.0474333333 8.692227e-01 7.018267e-06   FALSE
ENST00000693650 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 1.0623071 0.52642612 1.0986705 0.07679919 0.11244191 1.0473792 0.14422917 0.09860000 0.10090000 0.0023000000 1.000000e+00 7.018267e-06   FALSE
MSTRG.25407.14 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.5975377 0.38415550 1.0935046 0.11798962 0.31721246 1.4852558 0.07355417 0.07060000 0.09813333 0.0275333333 8.443483e-01 7.018267e-06   FALSE
MSTRG.25407.32 ENSG00000245958 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   7.879203 5.282499 10.8375 0.3054264 0.7626182 1.035341 0.4557946 0.28694217 0.2653397 0.04838529 0.26533966 -0.1089695 0.05495833 0.05580000 0.02246667 -0.0333333333 4.450515e-01 7.018267e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000245958 E001 0.1779838 0.045696119 0.7709048951   4 119454762 119454784 23 + 0.094 0.000 -10.209
ENSG00000245958 E002 0.5173834 0.126562580 0.2107057544   4 119454785 119454790 6 + 0.239 0.000 -13.087
ENSG00000245958 E003 0.8026527 0.017267182 0.0598454063   4 119454791 119454793 3 + 0.345 0.000 -13.768
ENSG00000245958 E004 0.8026527 0.017267182 0.0598454063   4 119454794 119454795 2 + 0.345 0.000 -13.768
ENSG00000245958 E005 0.8026527 0.017267182 0.0598454063   4 119454796 119454800 5 + 0.345 0.000 -13.768
ENSG00000245958 E006 1.3086294 0.013377599 0.9862634280   4 119454801 119454809 9 + 0.345 0.360 0.090
ENSG00000245958 E007 1.4512641 0.012943900 0.7852388259 0.887673326 4 119454810 119454813 4 + 0.390 0.360 -0.173
ENSG00000245958 E008 1.4512641 0.012943900 0.7852388259 0.887673326 4 119454814 119454814 1 + 0.390 0.360 -0.173
ENSG00000245958 E009 1.9686474 0.011267681 0.3529453982 0.589995633 4 119454815 119454825 11 + 0.503 0.360 -0.759
ENSG00000245958 E010 2.4560308 0.010826696 0.7211221713 0.848864470 4 119454826 119454829 4 + 0.534 0.498 -0.173
ENSG00000245958 E011 4.6660401 0.005814721 0.0517697212 0.183922708 4 119454830 119454838 9 + 0.818 0.554 -1.111
ENSG00000245958 E012 6.2304365 0.004755257 0.1135185967 0.305008601 4 119454839 119454845 7 + 0.905 0.724 -0.711
ENSG00000245958 E013 6.2304365 0.004755257 0.1135185967 0.305008601 4 119454846 119454847 2 + 0.905 0.724 -0.711
ENSG00000245958 E014 6.3730711 0.004595097 0.0911172572 0.265699611 4 119454848 119454849 2 + 0.917 0.724 -0.759
ENSG00000245958 E015 7.4915903 0.005014253 0.0797997010 0.244410421 4 119454850 119454853 4 + 0.977 0.789 -0.721
ENSG00000245958 E016 9.1280404 0.016985606 0.0886583639 0.261297606 4 119454854 119454859 6 + 1.050 0.870 -0.669
ENSG00000245958 E017 9.6290278 0.003920226 0.2130140477 0.445294105 4 119454860 119454863 4 + 1.049 0.941 -0.398
ENSG00000245958 E018 14.2624611 0.003055511 0.6578328222 0.808551560 4 119454864 119454895 32 + 1.178 1.168 -0.034
ENSG00000245958 E019 34.7163242 0.001742258 0.8369662557 0.917753273 4 119454896 119455133 238 + 1.525 1.569 0.150
ENSG00000245958 E020 0.6675801 0.355898127 0.6910856006   4 119457968 119457970 3 + 0.172 0.272 0.843
ENSG00000245958 E021 6.8397563 0.055042780 0.0456582461 0.169145968 4 119457971 119458077 107 + 0.969 0.647 -1.271
ENSG00000245958 E022 5.2968000 0.019054631 0.0082564107 0.050505310 4 119458078 119458170 93 + 0.892 0.498 -1.661
ENSG00000245958 E023 1.4011997 0.020089369 0.0791774497 0.243184404 4 119458171 119458238 68 + 0.468 0.155 -2.176
ENSG00000245958 E024 27.8649870 0.001766191 0.2143034837 0.446723382 4 119460183 119460242 60 + 1.467 1.413 -0.186
ENSG00000245958 E025 0.1426347 0.031980679 0.7721849280   4 119460243 119460244 2 + 0.094 0.000 -11.525
ENSG00000245958 E026 0.4702677 0.021647221 0.8930862819   4 119460437 119460730 294 + 0.172 0.155 -0.177
ENSG00000245958 E027 21.0148368 0.001713483 0.1141958770 0.306121236 4 119460731 119460742 12 + 1.362 1.270 -0.324
ENSG00000245958 E028 21.1675066 0.001876911 0.0697590259 0.224318092 4 119460743 119460820 78 + 1.371 1.260 -0.391
ENSG00000245958 E029 7.2355519 0.004668910 0.9172153574 0.960806963 4 119460821 119460827 7 + 0.904 0.919 0.055
ENSG00000245958 E030 26.8693296 0.001568367 0.3022037065 0.542833264 4 119461717 119461851 135 + 1.445 1.406 -0.135
ENSG00000245958 E031 3.8432511 0.006837430 0.3809123392 0.612961597 4 119461852 119462191 340 + 0.709 0.603 -0.455
ENSG00000245958 E032 38.3909936 0.001050748 0.0745560020 0.233910176 4 119462896 119462979 84 + 1.605 1.533 -0.246
ENSG00000245958 E033 30.0673293 0.014231831 0.0701877573 0.225138571 4 119479826 119480935 1110 + 1.395 1.581 0.638
ENSG00000245958 E034 13.1670896 0.055103891 0.4828700808 0.689037791 4 119488294 119488545 252 + 1.152 1.102 -0.182
ENSG00000245958 E035 1.2559042 0.013356840 0.1636041808   4 119488643 119488644 2 + 0.237 0.498 1.564
ENSG00000245958 E036 6.4960077 0.054364717 0.5115907114 0.709200266 4 119488645 119488717 73 + 0.803 0.943 0.538
ENSG00000245958 E037 38.6138639 0.036803493 0.6903618863 0.829302520 4 119493333 119493437 105 + 1.564 1.618 0.183
ENSG00000245958 E038 0.1723744 0.031539041 0.3007656167   4 119494426 119494432 7 + 0.000 0.155 12.864
ENSG00000245958 E039 34.5369531 0.660930619 0.3916470729 0.621746227 4 119494433 119494523 91 + 1.466 1.634 0.574
ENSG00000245958 E040 0.3032425 0.024441170 0.0976973280   4 119497662 119497810 149 + 0.000 0.269 13.846
ENSG00000245958 E041 29.4971960 0.594590543 0.3703745964 0.604278352 4 119497811 119497903 93 + 1.400 1.568 0.580
ENSG00000245958 E042 4.1594254 0.499067152 0.9766587142 0.990076910 4 119497904 119498292 389 + 0.691 0.727 0.149
ENSG00000245958 E043 23.3659493 0.002405460 0.9534787851 0.978670576 4 119499561 119499836 276 + 1.367 1.391 0.086
ENSG00000245958 E044 7.0733472 0.061546756 0.7873265354 0.888967661 4 119499837 119499871 35 + 0.901 0.876 -0.097
ENSG00000245958 E045 17.3859732 0.033896459 0.1414996672 0.349729268 4 119499872 119500279 408 + 1.290 1.148 -0.503
ENSG00000245958 E046 9.1892557 0.034218083 0.0989049096 0.279873504 4 119512351 119512372 22 + 0.902 1.139 0.870
ENSG00000245958 E047 15.4336113 0.037917743 0.4819527428 0.688363075 4 119512373 119512464 92 + 1.166 1.274 0.380
ENSG00000245958 E048 15.4281877 0.004977838 0.3836342292 0.615260324 4 119512813 119512920 108 + 1.163 1.270 0.377
ENSG00000245958 E049 10.2583654 0.016721859 0.8831937897 0.942938452 4 119512921 119512970 50 + 1.038 1.052 0.049
ENSG00000245958 E050 2.5201082 0.049096679 0.0381191784 0.149936612 4 119516973 119517105 133 + 0.345 0.727 1.841
ENSG00000245958 E051 0.6081007 0.019387492 0.1077435119   4 119519489 119519651 163 + 0.294 0.000 -13.460
ENSG00000245958 E052 8.4045792 0.028973520 0.6795244692 0.822427281 4 119528740 119528789 50 + 0.966 0.942 -0.090
ENSG00000245958 E053 3.4738540 0.080210601 0.7244520959 0.850796854 4 119528790 119528867 78 + 0.645 0.604 -0.181
ENSG00000245958 E054 1.1190667 0.014773233 0.7892599636   4 119543753 119543845 93 + 0.294 0.360 0.411
ENSG00000245958 E055 0.3032425 0.024441170 0.0976973280   4 119547707 119547728 22 + 0.000 0.269 13.846
ENSG00000245958 E056 39.1648392 0.033062915 0.0004032554 0.004762312 4 119548206 119550378 2173 + 1.402 1.789 1.319
ENSG00000245958 E057 11.5999021 0.003133774 0.4512493272 0.666520383 4 119550379 119550443 65 + 1.039 1.143 0.376
ENSG00000245958 E058 10.8962849 0.003225699 0.0798753409 0.244562697 4 119551888 119552025 138 + 0.977 1.181 0.740