ENSG00000245937

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000501702 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.1286442 0.00000000 0.3552548 0.00000000 0.3552548 5.19083138 0.01650833 0.00000000 0.06570000 0.06570000 8.113613e-01 1.266244e-13   FALSE
ENST00000660180 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.9325951 1.48030200 0.1267950 0.52523498 0.1267950 -3.44551706 0.06690000 0.09186667 0.01756667 -0.07430000 3.054537e-01 1.266244e-13   FALSE
ENST00000661296 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.6168202 0.67643236 0.2252783 0.02825079 0.2252783 -1.54474948 0.05189583 0.04546667 0.03040000 -0.01506667 5.928131e-01 1.266244e-13   FALSE
ENST00000668265 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.1909851 0.02352861 0.4096710 0.02352861 0.4096710 3.64579411 0.01892083 0.00140000 0.05673333 0.05533333 8.887167e-01 1.266244e-13   FALSE
ENST00000668567 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.6597071 0.37039086 0.3840311 0.05309470 0.3840311 0.05082683 0.06029167 0.02573333 0.05183333 0.02610000 7.923910e-01 1.266244e-13   FALSE
ENST00000687795 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 3.0831869 7.29325037 0.4227686 0.39852939 0.4227686 -4.07687102 0.22400417 0.48913333 0.07820000 -0.41093333 1.213439e-01 1.266244e-13   FALSE
ENST00000689029 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA lncRNA 12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 0.7727772 0.00000000 0.8878140 0.00000000 0.4872271 6.48834468 0.06780417 0.00000000 0.12103333 0.12103333 1.513910e-01 1.266244e-13   FALSE
MSTRG.26862.4 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA   12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 2.0891444 0.61187963 2.0827419 0.30699417 0.4223296 1.75068715 0.18830000 0.03583333 0.30500000 0.26916667 1.251631e-01 1.266244e-13   FALSE
MSTRG.26862.6 ENSG00000245937 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A2-DT lncRNA   12.43745 15.22858 6.677788 1.840786 0.6376839 -1.188128 1.3030124 2.68823397 0.0000000 0.54473772 0.0000000 -8.07587164 0.08588333 0.17256667 0.00000000 -0.17256667 1.266244e-13 1.266244e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000245937 E001 0.7035494 0.0386629514 5.302294e-02   5 127939152 127939249 98 - 0.417 0.077 -3.055
ENSG00000245937 E002 1.7914714 0.0107107064 1.145298e-05 2.355267e-04 5 127939250 127939721 472 - 0.804 0.077 -4.792
ENSG00000245937 E003 19.3929026 0.0017708637 8.686809e-09 4.140387e-07 5 127939722 127940901 1180 - 1.549 1.087 -1.614
ENSG00000245937 E004 13.2834230 0.0035865954 5.208664e-08 2.069125e-06 5 127940902 127940983 82 - 1.427 0.911 -1.848
ENSG00000245937 E005 30.6347384 0.0265379191 6.260346e-04 6.804165e-03 5 127940984 127941220 237 - 1.683 1.322 -1.241
ENSG00000245937 E006 19.3616815 0.0023288143 2.240493e-01 4.582345e-01 5 127956804 127956921 118 - 1.341 1.223 -0.415
ENSG00000245937 E007 0.1308682 0.0309374869 1.000000e+00   5 127965883 127965884 2 - 0.000 0.077 11.302
ENSG00000245937 E008 0.1308682 0.0309374869 1.000000e+00   5 127965885 127965887 3 - 0.000 0.077 11.302
ENSG00000245937 E009 20.6404279 0.0065132412 1.581328e-01 3.739725e-01 5 127965888 127966162 275 - 1.191 1.306 0.405
ENSG00000245937 E010 88.0654931 0.0029488244 4.995999e-02 1.795859e-01 5 127966163 127966548 386 - 1.840 1.917 0.261
ENSG00000245937 E011 88.1740586 0.0036750455 7.754176e-02 2.399242e-01 5 127966549 127966672 124 - 1.844 1.915 0.240
ENSG00000245937 E012 73.4658606 0.0006909855 4.136916e-04 4.864533e-03 5 127966673 127966734 62 - 1.703 1.855 0.515
ENSG00000245937 E013 53.1398671 0.0010417925 2.718045e-04 3.445962e-03 5 127966735 127966767 33 - 1.522 1.717 0.667
ENSG00000245937 E014 59.3912350 0.0057338178 4.018220e-04 4.750008e-03 5 127966768 127966816 49 - 1.555 1.767 0.718
ENSG00000245937 E015 61.9324890 0.0008559260 1.372393e-05 2.757826e-04 5 127966817 127966849 33 - 1.568 1.787 0.744
ENSG00000245937 E016 70.6411109 0.0031532237 1.314256e-05 2.660518e-04 5 127966850 127966928 79 - 1.616 1.846 0.778
ENSG00000245937 E017 0.1723744 0.0372784229 1.000000e+00   5 128002529 128002694 166 - 0.000 0.077 11.279
ENSG00000245937 E018 0.1723744 0.0372784229 1.000000e+00   5 128002695 128002738 44 - 0.000 0.077 11.279
ENSG00000245937 E019 0.3751086 0.0265680397 6.306671e-01   5 128002739 128002822 84 - 0.000 0.143 12.284
ENSG00000245937 E020 0.2027342 0.0359619934 1.000000e+00   5 128002823 128003643 821 - 0.000 0.077 11.286
ENSG00000245937 E021 0.2027342 0.0359619934 1.000000e+00   5 128003644 128003986 343 - 0.000 0.077 11.286
ENSG00000245937 E022 0.0000000       5 128003987 128003988 2 -      
ENSG00000245937 E023 0.0000000       5 128021528 128021587 60 -      
ENSG00000245937 E024 46.8986264 0.0059405686 6.800519e-40 1.110466e-36 5 128021588 128024026 2439 - 2.058 1.231 -2.821
ENSG00000245937 E025 6.3140461 0.1063003906 1.339728e-03 1.245847e-02 5 128024027 128024134 108 - 1.162 0.570 -2.314
ENSG00000245937 E026 7.7520370 0.0095641139 1.615276e-04 2.236717e-03 5 128024135 128024298 164 - 1.175 0.706 -1.774
ENSG00000245937 E027 0.0000000       5 128055402 128057007 1606 -      
ENSG00000245937 E028 0.1614157 0.0327055232 1.774017e-01   5 128057008 128057013 6 - 0.187 0.000 -14.387
ENSG00000245937 E029 0.1614157 0.0327055232 1.774017e-01   5 128057014 128057014 1 - 0.187 0.000 -14.387
ENSG00000245937 E030 0.1614157 0.0327055232 1.774017e-01   5 128057015 128057023 9 - 0.187 0.000 -14.387
ENSG00000245937 E031 0.4654660 0.0237266336 1.065748e-02   5 128057024 128057156 133 - 0.417 0.000 -15.958
ENSG00000245937 E032 8.2191371 0.0035384790 4.563924e-07 1.428944e-05 5 128057157 128059948 2792 - 1.260 0.688 -2.150
ENSG00000245937 E033 3.8385285 0.0628395898 3.011305e-01 5.415993e-01 5 128059949 128060644 696 - 0.769 0.572 -0.835
ENSG00000245937 E034 88.1680467 0.0005944960 8.053205e-02 2.459172e-01 5 128061144 128061244 101 - 1.850 1.907 0.192
ENSG00000245937 E035 0.9520415 0.1092357371 7.703765e-01   5 128061245 128062369 1125 - 0.316 0.249 -0.466
ENSG00000245937 E036 0.1723744 0.0372784229 1.000000e+00   5 128062370 128062373 4 - 0.000 0.077 11.279
ENSG00000245937 E037 0.1723744 0.0372784229 1.000000e+00   5 128062374 128062500 127 - 0.000 0.077 11.279
ENSG00000245937 E038 1.1417919 0.2154991419 1.641901e-01   5 128062501 128064067 1567 - 0.497 0.201 -1.859
ENSG00000245937 E039 2.3107396 0.0107583825 1.162036e-01 3.095104e-01 5 128064737 128064850 114 - 0.678 0.406 -1.282
ENSG00000245937 E040 4.3753001 0.0102183587 8.040118e-01 8.986237e-01 5 128076947 128077093 147 - 0.677 0.704 0.110
ENSG00000245937 E041 27.1902808 0.0015647487 5.942601e-01 7.665084e-01 5 128081973 128082191 219 - 1.436 1.381 -0.191
ENSG00000245937 E042 7.5519576 0.0039600243 3.518159e-01 5.888981e-01 5 128082192 128082194 3 - 0.804 0.912 0.416
ENSG00000245937 E043 89.3428146 0.0034377218 2.123410e-02 1.001038e-01 5 128082735 128082969 235 - 1.824 1.923 0.334
ENSG00000245937 E044 48.5671558 0.0151252583 3.326396e-02 1.367566e-01 5 128082970 128083172 203 - 1.515 1.677 0.552