ENSG00000245694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000501177 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 1.5567242 1.0293796 1.7251463 0.41528567 0.1288706 0.73933467 0.05992083 0.06443333 0.05950000 -0.004933333 1.000000e+00 5.280781e-05    
ENST00000557792 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 0.9059278 0.2223928 2.8336060 0.03867142 0.3473625 3.61308416 0.03526667 0.01493333 0.09853333 0.083600000 5.280781e-05 5.280781e-05 FALSE  
ENST00000558031 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 10.4464220 7.2326388 7.1678494 1.33472576 0.7234892 -0.01296377 0.41225833 0.46750000 0.24593333 -0.221566667 1.420410e-01 5.280781e-05    
ENST00000558952 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 1.2873388 0.5963930 2.7444235 0.05855363 0.4220835 2.18342536 0.04595000 0.03953333 0.09353333 0.054000000 5.935882e-02 5.280781e-05 TRUE  
ENST00000655114 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 3.3869649 2.0360474 6.1688870 1.04695718 1.7993843 1.59450744 0.13467083 0.13373333 0.20666667 0.072933333 8.546693e-01 5.280781e-05    
ENST00000688921 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 1.8668259 0.7130537 1.7133678 0.43515717 0.2614783 1.25305604 0.07190000 0.04826667 0.05856667 0.010300000 8.737898e-01 5.280781e-05    
ENST00000691307 ENSG00000245694 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 25.74758 15.33878 29.24922 1.193609 1.554634 0.9307672 2.1389236 1.2554263 0.5399049 0.23738493 0.2747476 -1.20236949 0.07992917 0.08100000 0.01896667 -0.062033333 4.183925e-01 5.280781e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000245694 E001 0.0000000       16 54845189 54845421 233 -      
ENSG00000245694 E002 0.0000000       16 54847175 54847246 72 -      
ENSG00000245694 E003 0.0000000       16 54847247 54847398 152 -      
ENSG00000245694 E004 0.0000000       16 54847399 54847573 175 -      
ENSG00000245694 E005 0.0000000       16 54847976 54848140 165 -      
ENSG00000245694 E006 0.0000000       16 54848141 54848287 147 -      
ENSG00000245694 E007 0.0000000       16 54848288 54848319 32 -      
ENSG00000245694 E008 0.0000000       16 54848527 54848607 81 -      
ENSG00000245694 E009 0.0000000       16 54848691 54848760 70 -      
ENSG00000245694 E010 0.0000000       16 54849356 54849497 142 -      
ENSG00000245694 E011 0.0000000       16 54851640 54851642 3 -      
ENSG00000245694 E012 19.6059389 0.0057393413 3.839234e-01 6.155206e-01 16 54851643 54852902 1260 - 1.362 1.200 -0.569
ENSG00000245694 E013 9.8236700 0.0520738867 9.396629e-01 9.720450e-01 16 54852903 54853437 535 - 1.057 0.973 -0.309
ENSG00000245694 E014 4.5260981 0.0447093459 7.300943e-01 8.542920e-01 16 54853438 54853568 131 - 0.752 0.732 -0.079
ENSG00000245694 E015 0.0000000       16 54874055 54874170 116 -      
ENSG00000245694 E016 0.0000000       16 54876259 54876394 136 -      
ENSG00000245694 E017 7.0036077 0.0362036173 6.852158e-01 8.260246e-01 16 54891402 54891665 264 - 0.901 0.875 -0.096
ENSG00000245694 E018 3.4452796 0.1370563866 7.351965e-01 8.573734e-01 16 54893322 54893483 162 - 0.657 0.629 -0.121
ENSG00000245694 E019 6.3948710 0.0123853887 7.377866e-01 8.591254e-01 16 54916492 54917955 1464 - 0.916 0.793 -0.474
ENSG00000245694 E020 0.1426347 0.0318529872 9.760865e-01   16 54917956 54917967 12 - 0.100 0.000 -9.160
ENSG00000245694 E021 0.1426347 0.0318529872 9.760865e-01   16 54917968 54917969 2 - 0.100 0.000 -9.160
ENSG00000245694 E022 16.8499942 0.0147013587 1.940810e-02 9.387208e-02 16 54917970 54918688 719 - 1.356 1.024 -1.180
ENSG00000245694 E023 3.7166576 0.0194567860 2.080281e-02 9.868144e-02 16 54918689 54918862 174 - 0.808 0.343 -2.174
ENSG00000245694 E024 0.6058878 0.1153383618 1.671968e-01   16 54918863 54918869 7 - 0.307 0.000 -11.152
ENSG00000245694 E025 2.4634282 0.2443634774 4.008370e-01 6.289681e-01 16 54918870 54918916 47 - 0.609 0.354 -1.279
ENSG00000245694 E026 2.6296455 0.0432722605 4.778322e-01 6.856616e-01 16 54918917 54918925 9 - 0.613 0.418 -0.940
ENSG00000245694 E027 2.9750144 0.1735664179 6.810556e-01 8.233474e-01 16 54918926 54918930 5 - 0.637 0.488 -0.686
ENSG00000245694 E028 3.6472085 0.0442413772 5.548294e-01 7.396620e-01 16 54918931 54918932 2 - 0.640 0.667 0.115
ENSG00000245694 E029 10.8615942 0.0029003738 9.294426e-01 9.667467e-01 16 54918933 54918941 9 - 1.102 1.010 -0.335
ENSG00000245694 E030 33.9897951 0.0013633776 3.827654e-01 6.145169e-01 16 54918942 54918966 25 - 1.543 1.510 -0.115
ENSG00000245694 E031 86.5354162 0.0010027739 1.809677e-02 8.934378e-02 16 54918967 54919046 80 - 1.928 1.934 0.018
ENSG00000245694 E032 72.5478211 0.0009506816 3.031266e-02 1.283001e-01 16 54919047 54919052 6 - 1.851 1.856 0.016
ENSG00000245694 E033 160.1282766 0.0003343714 1.031137e-07 3.811730e-06 16 54919053 54919156 104 - 2.173 2.233 0.199
ENSG00000245694 E034 179.8950862 0.0008806702 7.037544e-07 2.093793e-05 16 54919157 54919209 53 - 2.228 2.279 0.171
ENSG00000245694 E035 141.1118274 0.0136292713 1.278094e-10 8.855560e-09 16 54919210 54920297 1088 - 2.284 1.770 -1.725
ENSG00000245694 E036 165.5785859 0.0023311617 6.367372e-05 1.024468e-03 16 54920298 54920327 30 - 2.195 2.241 0.156
ENSG00000245694 E037 136.3256218 0.0004062771 5.226430e-07 1.609663e-05 16 54920328 54920338 11 - 2.104 2.168 0.213
ENSG00000245694 E038 179.6102597 0.0003922237 9.570941e-08 3.569095e-06 16 54920339 54920410 72 - 2.227 2.280 0.176
ENSG00000245694 E039 328.5476616 0.0312631217 1.220894e-10 8.497371e-09 16 54920411 54923584 3174 - 2.664 2.053 -2.037
ENSG00000245694 E040 203.0928052 0.0041015893 3.809595e-05 6.611046e-04 16 54923585 54923650 66 - 2.276 2.337 0.203
ENSG00000245694 E041 73.5740540 0.1187702909 3.835931e-02 1.505116e-01 16 54923651 54924600 950 - 1.977 1.600 -1.274
ENSG00000245694 E042 16.3636822 0.2681067586 2.193319e-01 4.526052e-01 16 54924601 54924687 87 - 1.333 1.006 -1.168
ENSG00000245694 E043 8.4929268 0.0198822017 5.251553e-02 1.855167e-01 16 54924688 54924858 171 - 1.076 0.733 -1.305
ENSG00000245694 E044 15.0240312 0.0730263180 1.203246e-01 3.163602e-01 16 54924859 54925100 242 - 1.299 0.958 -1.228
ENSG00000245694 E045 166.9287837 0.0015518931 3.583506e-06 8.650486e-05 16 54925101 54925213 113 - 2.194 2.251 0.189
ENSG00000245694 E046 2.6202795 0.0086431445 4.299691e-01 6.510512e-01 16 54925214 54925236 23 - 0.614 0.416 -0.951
ENSG00000245694 E047 9.6758556 0.0349243912 1.314717e-02 7.104151e-02 16 54926881 54928004 1124 - 1.148 0.699 -1.707
ENSG00000245694 E048 2.2522556 0.1554020200 3.162863e-01 5.563373e-01 16 54928005 54928304 300 - 0.610 0.337 -1.393
ENSG00000245694 E049 17.4067614 0.0037070449 8.165253e-01 9.061843e-01 16 54928494 54928769 276 - 1.277 1.211 -0.230
ENSG00000245694 E050 47.9060875 0.0009035472 7.106705e-13 7.491508e-11 16 54928770 54929189 420 - 1.543 1.823 0.948