ENSG00000245293

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000658105 ENSG00000245293 HEK293_OSMI2_6hA HEK293_TMG_6hB CYP2U1-AS1 lncRNA lncRNA 0.9169914 0.281008 0.662179 0.05455797 0.03537272 1.207786 0.2099829 0.21407525 0.1573414 0.01903394 0.02518860 -0.4211892 0.3623250 0.79203333 0.2378333 -0.5542 0.01237321 0.01237321   FALSE
ENST00000686573 ENSG00000245293 HEK293_OSMI2_6hA HEK293_TMG_6hB CYP2U1-AS1 lncRNA lncRNA 0.9169914 0.281008 0.662179 0.05455797 0.03537272 1.207786 0.5073475 0.00000000 0.0000000 0.00000000 0.00000000 0.0000000 0.3535875 0.00000000 0.0000000 0.0000   0.01237321   FALSE
ENST00000687236 ENSG00000245293 HEK293_OSMI2_6hA HEK293_TMG_6hB CYP2U1-AS1 lncRNA lncRNA 0.9169914 0.281008 0.662179 0.05455797 0.03537272 1.207786 0.1585326 0.03615825 0.4175697 0.03615825 0.01313848 3.2114991 0.2196208 0.09313333 0.6322333 0.5391 0.02738076 0.01237321   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000245293 E001 0.1614157 0.034767197 0.275925761   4 107863473 107863478 6 - 0.161 0.000 -11.403
ENSG00000245293 E002 0.1614157 0.034767197 0.275925761   4 107863479 107863667 189 - 0.161 0.000 -13.459
ENSG00000245293 E003 0.1614157 0.034767197 0.275925761   4 107863668 107864446 779 - 0.161 0.000 -13.459
ENSG00000245293 E004 0.1308682 0.037325432 0.872125042   4 107866908 107867645 738 - 0.000 0.090 10.790
ENSG00000245293 E005 0.0000000       4 107873330 107873444 115 -      
ENSG00000245293 E006 0.0000000       4 107873980 107874088 109 -      
ENSG00000245293 E007 0.0000000       4 107874845 107874892 48 -      
ENSG00000245293 E008 0.0000000       4 107886667 107886716 50 -      
ENSG00000245293 E009 0.5775531 0.022009888 0.120258928   4 107886717 107886826 110 - 0.371 0.090 -2.543
ENSG00000245293 E010 0.4632531 0.031032063 0.027056101   4 107887082 107887230 149 - 0.371 0.000 -14.582
ENSG00000245293 E011 1.0893270 0.015201234 0.059819720   4 107893067 107893163 97 - 0.512 0.165 -2.281
ENSG00000245293 E012 0.0000000       4 107893164 107893495 332 -      
ENSG00000245293 E013 1.3279580 0.019322319 0.443255564   4 107893496 107893637 142 - 0.447 0.285 -0.952
ENSG00000245293 E014 0.4054685 0.454788161 0.547841225   4 107907226 107907397 172 - 0.000 0.173 11.528
ENSG00000245293 E015 0.5421338 0.026626845 0.288518900   4 107907398 107907769 372 - 0.279 0.091 -1.957
ENSG00000245293 E016 8.5693997 0.109984695 0.121043373 0.31753505 4 107907770 107910340 2571 - 1.102 0.870 -0.860
ENSG00000245293 E017 0.9225915 0.093192923 0.082141141   4 107910341 107910391 51 - 0.000 0.338 12.623
ENSG00000245293 E018 6.0136695 0.013569685 0.001345585 0.01250199 4 107910392 107910549 158 - 0.511 0.914 1.684
ENSG00000245293 E019 0.1723744 0.036897989 0.872016337   4 107910550 107914990 4441 - 0.000 0.091 10.794
ENSG00000245293 E020 0.0000000       4 107921939 107922010 72 -      
ENSG00000245293 E021 0.3088520 0.032267850 0.674717927   4 107931971 107932264 294 - 0.161 0.090 -0.963
ENSG00000245293 E022 0.0000000       4 107978720 107978982 263 -      
ENSG00000245293 E023 7.6097811 0.009019753 0.091747256 0.26692697 4 107989568 107989692 125 - 0.805 0.949 0.552