ENSG00000243970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000645296 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 0.46819779 0.2826021 0.8995091 0.2031335 0.08972647 1.6361481 0.052791667 0.02056667 0.14173333 0.12116667 0.04593881 0.008025622 TRUE FALSE
ENST00000647627 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 1.09222399 1.3095810 0.8619133 0.6327180 0.17842127 -0.5978233 0.120558333 0.10456667 0.13490000 0.03033333 0.86155705 0.008025622   FALSE
ENST00000649325 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 0.94240085 1.2658507 0.4467608 0.3479524 0.22490213 -1.4819488 0.105350000 0.10963333 0.07026667 -0.03936667 0.80174221 0.008025622 TRUE FALSE
ENST00000687069 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 0.05938565 0.4750852 0.0000000 0.2884361 0.00000000 -5.6001663 0.006583333 0.05266667 0.00000000 -0.05266667 0.49096660 0.008025622 FALSE FALSE
ENST00000688421 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 0.58016134 0.4175751 0.7189869 0.4175751 0.15022559 0.7697149 0.070520833 0.02683333 0.11410000 0.08726667 0.29258402 0.008025622 FALSE FALSE
ENST00000692918 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 0.58060658 0.6304040 0.1649483 0.4583987 0.16494826 -1.8720541 0.073687500 0.06786667 0.02586667 -0.04200000 0.80681015 0.008025622 FALSE FALSE
MSTRG.907.29 ENSG00000243970 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIEL transcribed_unprocessed_pseudogene   8.727698 11.27516 6.360047 2.147575 0.1322364 -0.8250506 2.17740257 3.3633122 2.0913322 0.5170087 0.33058058 -0.6828616 0.247362500 0.30203333 0.32936667 0.02733333 0.95427877 0.008025622   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000243970 E001 0.3751086 0.024441170 5.759945e-01   1 39522280 39522282 3 - 0.000 0.152 11.897
ENSG00000243970 E002 0.3751086 0.024441170 5.759945e-01   1 39522283 39522286 4 - 0.000 0.152 11.897
ENSG00000243970 E003 0.3751086 0.024441170 5.759945e-01   1 39522287 39522287 1 - 0.000 0.152 11.897
ENSG00000243970 E004 0.5474829 0.021713489 3.385811e-01   1 39522288 39522299 12 - 0.000 0.212 12.483
ENSG00000243970 E005 0.8703143 0.050464127 6.164086e-01   1 39522300 39522313 14 - 0.300 0.213 -0.652
ENSG00000243970 E006 0.8703143 0.050464127 6.164086e-01   1 39522314 39522325 12 - 0.300 0.213 -0.652
ENSG00000243970 E007 1.8223558 0.019415274 6.044325e-01 7.731799e-01 1 39522326 39522350 25 - 0.475 0.393 -0.433
ENSG00000243970 E008 13.5842210 0.003492514 7.959524e-02 2.440527e-01 1 39522351 39522471 121 - 0.975 1.172 0.716
ENSG00000243970 E009 17.4077275 0.007117438 7.797512e-02 2.407502e-01 1 39522472 39522505 34 - 1.093 1.275 0.647
ENSG00000243970 E010 4.5485795 0.058471928 4.140185e-01 6.390270e-01 1 39523558 39523561 4 - 0.598 0.740 0.601
ENSG00000243970 E011 19.1489266 0.148899795 4.415158e-01 6.597574e-01 1 39523562 39523697 136 - 1.201 1.291 0.317
ENSG00000243970 E012 11.5136759 0.458873120 5.873818e-01 7.618775e-01 1 39523807 39523844 38 - 0.972 1.096 0.453
ENSG00000243970 E013 13.2770297 0.297250001 6.629132e-01 8.117058e-01 1 39523845 39523896 52 - 1.056 1.144 0.316
ENSG00000243970 E014 32.1406565 0.304472733 3.585808e-01 5.946223e-01 1 39523897 39524835 939 - 1.352 1.525 0.597
ENSG00000243970 E015 20.5540364 0.005853406 3.262890e-06 7.975155e-05 1 39524836 39525057 222 - 0.900 1.393 1.771
ENSG00000243970 E016 8.9621150 0.034833944 5.081101e-02 1.816109e-01 1 39525058 39525151 94 - 0.737 1.040 1.161
ENSG00000243970 E017 20.8319372 0.222382691 6.045336e-01 7.732132e-01 1 39525152 39525685 534 - 1.262 1.317 0.192
ENSG00000243970 E018 12.6928059 0.074128089 6.176587e-01 7.822359e-01 1 39525699 39525848 150 - 1.031 1.126 0.343
ENSG00000243970 E019 14.7125914 0.217720938 4.239348e-01 6.464885e-01 1 39527617 39527829 213 - 1.034 1.203 0.607
ENSG00000243970 E020 4.6686766 0.020948185 8.990347e-01 9.513705e-01 1 39529016 39529054 39 - 0.696 0.718 0.091
ENSG00000243970 E021 23.5874042 0.273068020 3.651744e-01 6.000949e-01 1 39529055 39529164 110 - 1.269 1.382 0.395
ENSG00000243970 E022 1.2369804 0.248217208 1.507601e-01   1 39531838 39531896 59 - 0.000 0.402 13.753
ENSG00000243970 E023 0.6479912 0.019695761 2.121810e-01   1 39537191 39537343 153 - 0.000 0.264 12.894
ENSG00000243970 E024 0.8092192 0.017458692 1.326025e-01   1 39541657 39541719 63 - 0.000 0.311 13.215
ENSG00000243970 E025 23.3058928 0.033041436 6.853295e-01 8.260855e-01 1 39541720 39541839 120 - 1.391 1.330 -0.214
ENSG00000243970 E026 7.7388425 0.004209800 1.227318e-02 6.754164e-02 1 39541840 39541841 2 - 1.077 0.796 -1.059
ENSG00000243970 E027 25.8811173 0.006480773 2.386461e-01 4.750615e-01 1 39545733 39545857 125 - 1.445 1.359 -0.295
ENSG00000243970 E028 21.2102714 0.059533647 3.013161e-01 5.417896e-01 1 39545858 39546187 330 - 1.351 1.287 -0.223
ENSG00000243970 E029 13.1662868 0.003971587 3.356258e-01 5.740997e-01 1 39547579 39547608 30 - 1.159 1.077 -0.296
ENSG00000243970 E030 12.5025335 0.002684489 4.775983e-01 6.854784e-01 1 39547609 39547629 21 - 1.127 1.068 -0.213
ENSG00000243970 E031 11.1373888 0.003134805 3.990868e-01 6.274742e-01 1 39547630 39547634 5 - 1.094 1.019 -0.274
ENSG00000243970 E032 7.9607034 0.092148865 4.107950e-01 6.366173e-01 1 39547635 39547708 74 - 0.950 0.897 -0.202
ENSG00000243970 E033 5.9875872 0.065275540 3.769639e-01 6.098302e-01 1 39547709 39547749 41 - 0.872 0.772 -0.391
ENSG00000243970 E034 44.9952259 0.032708248 2.015199e-02 9.642102e-02 1 39547750 39548669 920 - 1.726 1.570 -0.532
ENSG00000243970 E035 4.8994034 0.006336926 1.403772e-01 3.480948e-01 1 39548670 39548682 13 - 0.872 0.678 -0.776
ENSG00000243970 E036 8.6763393 0.003830050 3.471413e-01 5.846614e-01 1 39548683 39548746 64 - 1.018 0.921 -0.362
ENSG00000243970 E037 8.5642403 0.031936172 6.649236e-01 8.129833e-01 1 39548747 39548861 115 - 0.952 0.935 -0.064
ENSG00000243970 E038 26.5770236 0.018894524 4.028966e-01 6.306819e-01 1 39548862 39548951 90 - 1.437 1.376 -0.208
ENSG00000243970 E039 0.6536007 0.019387492 8.837075e-01   1 39549790 39549896 107 - 0.175 0.212 0.339
ENSG00000243970 E040 14.5182667 0.076837552 8.722994e-01 9.371991e-01 1 39553118 39553144 27 - 1.150 1.149 -0.004
ENSG00000243970 E041 25.6883670 0.117622006 5.577476e-01 7.416619e-01 1 39554349 39554392 44 - 1.321 1.407 0.301
ENSG00000243970 E042 2.4384671 0.009544740 1.592025e-01 3.755608e-01 1 39556134 39556201 68 - 0.651 0.428 -1.052
ENSG00000243970 E043 14.2310682 0.132730123 6.582495e-01 8.088632e-01 1 39556599 39556738 140 - 1.086 1.159 0.263
ENSG00000243970 E044 3.1827444 0.104518444 1.360564e-01 3.414245e-01 1 39556739 39556740 2 - 0.301 0.650 1.791
ENSG00000243970 E045 14.3701021 0.002862158 2.823944e-01 5.227954e-01 1 39557002 39557143 142 - 1.202 1.113 -0.317
ENSG00000243970 E046 1.2545489 0.303208340 8.481713e-01   1 39558584 39558637 54 - 0.304 0.346 0.265
ENSG00000243970 E047 3.7179989 0.105965123 7.185572e-01 8.473370e-01 1 39558638 39558959 322 - 0.656 0.622 -0.146
ENSG00000243970 E048 2.0519967 0.018449995 3.526579e-01 5.896991e-01 1 39558960 39559215 256 - 0.300 0.492 1.082
ENSG00000243970 E049 38.5577390 0.057389150 7.889923e-01 8.898787e-01 1 39559216 39559365 150 - 1.577 1.545 -0.109
ENSG00000243970 E050 24.5251779 0.012072971 5.470934e-01 7.342254e-01 1 39559366 39559493 128 - 1.387 1.347 -0.141
ENSG00000243970 E051 14.2277753 0.041295495 1.780865e-01 4.012948e-01 1 39559494 39559633 140 - 1.229 1.088 -0.502
ENSG00000243970 E052 5.8077553 0.004866663 5.906471e-01 7.641564e-01 1 39559634 39559698 65 - 0.738 0.824 0.342