ENSG00000243660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315429 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding protein_coding 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.16413434 0.02607985 0.09379825 0.02607985 0.04755833 1.524517 0.09485417 0.01746667 0.0679000 0.05043333 7.731296e-01 3.815511e-05 FALSE FALSE
ENST00000437590 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding protein_coding 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.28991241 0.12545662 0.44712815 0.06970301 0.22412493 1.754768 0.20117500 0.12273333 0.3353667 0.21263333 8.548076e-01 3.815511e-05 FALSE TRUE
ENST00000451167 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding protein_coding 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.06393343 0.00000000 0.17012755 0.00000000 0.17012755 4.170947 0.02952083 0.00000000 0.1066667 0.10666667 9.006728e-01 3.815511e-05   FALSE
ENST00000490208 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding processed_transcript 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.75622264 0.80013324 0.39054384 0.14432581 0.07981118 -1.016199 0.50214167 0.69376667 0.2520667 -0.44170000 3.815511e-05 3.815511e-05   FALSE
ENST00000652684 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding protein_coding 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.05281242 0.08444728 0.00000000 0.08444728 0.00000000 -3.239509 0.03725000 0.07846667 0.0000000 -0.07846667 8.555308e-01 3.815511e-05 FALSE TRUE
ENST00000689627 ENSG00000243660 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF487 protein_coding protein_coding 1.540091 1.146137 1.519434 0.1840869 0.1905557 0.4036858 0.13008847 0.05601211 0.29431934 0.05601211 0.29431934 2.204783 0.07810833 0.03750000 0.1630333 0.12553333 1.000000e+00 3.815511e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000243660 E001 0.4644705 0.024441170 0.0528208163   10 43436841 43436847 7 + 0.000 0.319 10.522
ENSG00000243660 E002 0.9594886 0.018550436 0.0488737688   10 43436848 43436872 25 + 0.110 0.448 2.649
ENSG00000243660 E003 1.9288384 0.014973023 0.0029330878 0.022997635 10 43436873 43436935 63 + 0.197 0.695 2.781
ENSG00000243660 E004 0.3807181 0.028637862 0.8539886485   10 43436936 43437110 175 + 0.110 0.134 0.330
ENSG00000243660 E005 0.3559677 0.515902672 0.4273766594   10 43437111 43437125 15 + 0.202 0.000 -11.772
ENSG00000243660 E006 1.4108030 0.190057010 0.5186060470 0.714113434 10 43437126 43437147 22 + 0.441 0.312 -0.746
ENSG00000243660 E007 1.8622896 0.018624849 0.4405098645 0.659124970 10 43437148 43437155 8 + 0.520 0.387 -0.682
ENSG00000243660 E008 0.8912068 0.098659531 0.8558653606   10 43437156 43437157 2 + 0.271 0.315 0.296
ENSG00000243660 E009 1.5813244 0.013797619 0.3122933632 0.552604883 10 43437158 43437262 105 + 0.333 0.501 0.912
ENSG00000243660 E010 1.2370530 0.143260923 0.1704233506   10 43451920 43454064 2145 + 0.199 0.453 1.659
ENSG00000243660 E011 8.3038108 0.004226834 0.0003536326 0.004273878 10 43454065 43454532 468 + 0.770 1.135 1.368
ENSG00000243660 E012 1.4454669 0.022375971 0.4851987559 0.690709933 10 43454533 43454664 132 + 0.332 0.449 0.654
ENSG00000243660 E013 0.0000000       10 43475696 43475720 25 +      
ENSG00000243660 E014 2.3344602 0.037996725 0.4505939474 0.666138733 10 43475721 43475830 110 + 0.588 0.448 -0.671
ENSG00000243660 E015 1.7193450 0.112021574 0.7046903896 0.838519300 10 43475831 43475847 17 + 0.477 0.389 -0.465
ENSG00000243660 E016 1.9443271 0.228421103 0.5944030456 0.766597875 10 43476107 43476202 96 + 0.547 0.385 -0.823
ENSG00000243660 E017 4.5516724 0.006203865 0.1478543500 0.359215526 10 43481429 43481678 250 + 0.830 0.628 -0.825
ENSG00000243660 E018 3.0236550 0.008278740 0.7644396465 0.875271742 10 43481679 43481731 53 + 0.589 0.628 0.175
ENSG00000243660 E019 20.5300210 0.012074890 0.0018956881 0.016374384 10 43481732 43483181 1450 + 1.421 1.188 -0.813