ENSG00000243176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460796 ENSG00000243176 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA retained_intron 0.6550493 0.6823215 0.4985116 0.2624688 0.0836586 -0.4451616 0.08564938 0.00000000 0.07882525 0.00000000 0.07882525 3.150970 0.11136667 0.0000000 0.1255333 0.1255333 0.79472944 0.03429819   FALSE
ENST00000475102 ENSG00000243176 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.6550493 0.6823215 0.4985116 0.2624688 0.0836586 -0.4451616 0.02777697 0.14931993 0.00000000 0.14931993 0.00000000 -3.993855 0.02333333 0.1287000 0.0000000 -0.1287000 0.86677827 0.03429819   FALSE
ENST00000487238 ENSG00000243176 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.6550493 0.6823215 0.4985116 0.2624688 0.0836586 -0.4451616 0.05410500 0.06456217 0.00000000 0.06456217 0.00000000 -2.898444 0.06608333 0.1022667 0.0000000 -0.1022667 0.87941875 0.03429819   FALSE
ENST00000667900 ENSG00000243176 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.6550493 0.6823215 0.4985116 0.2624688 0.0836586 -0.4451616 0.38687928 0.41041259 0.21451080 0.11611318 0.02023572 -0.905021 0.63632500 0.6625333 0.4606667 -0.2018667 0.68281577 0.03429819   FALSE
ENST00000691958 ENSG00000243176 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.6550493 0.6823215 0.4985116 0.2624688 0.0836586 -0.4451616 0.05764991 0.02425786 0.19826117 0.02425786 0.06669005 2.603887 0.09828333 0.0209000 0.4006333 0.3797333 0.03429819 0.03429819   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000243176 E001 3.7019907 0.140316610 0.59597845 0.76773178 3 157174201 157174555 355 + 0.567 0.690 0.536
ENSG00000243176 E002 9.5295008 0.149748641 0.58989214 0.76364586 3 157174749 157175220 472 + 0.869 1.046 0.662
ENSG00000243176 E003 2.3824002 0.016833226 0.94920346 0.97670405 3 157175221 157175222 2 + 0.451 0.488 0.186
ENSG00000243176 E004 4.1619468 0.045719474 0.61723773 0.78191489 3 157175223 157175267 45 + 0.573 0.699 0.549
ENSG00000243176 E005 2.6552828 0.010147421 0.65601339 0.80736779 3 157175268 157175268 1 + 0.451 0.547 0.470
ENSG00000243176 E006 4.4966646 0.006384146 0.57241098 0.75196329 3 157175269 157175346 78 + 0.622 0.729 0.451
ENSG00000243176 E007 3.8415338 0.008968662 0.86287286 0.93193424 3 157175347 157175389 43 + 0.622 0.669 0.202
ENSG00000243176 E008 4.1986692 0.008363578 0.67261947 0.81797599 3 157175390 157175617 228 + 0.707 0.669 -0.158
ENSG00000243176 E009 15.5068717 0.003043736 0.00237098 0.01950903 3 157175618 157176992 1375 + 1.304 1.103 -0.711
ENSG00000243176 E010 3.9158011 0.007652924 0.27054667 0.51051355 3 157176993 157177930 938 + 0.515 0.710 0.857
ENSG00000243176 E011 0.0000000       3 157213544 157213775 232 +      
ENSG00000243176 E012 0.1426347 0.033483363 0.23270072   3 157230279 157230297 19 + 0.163 0.000 -13.594
ENSG00000243176 E013 1.0018026 0.018148124 0.36111043   3 157239590 157239799 210 + 0.374 0.227 -0.991
ENSG00000243176 E014 0.0000000       3 157239800 157239964 165 +      
ENSG00000243176 E015 0.5474829 0.163846695 0.29211278   3 157282468 157283764 1297 + 0.000 0.230 12.891
ENSG00000243176 E016 0.0000000       3 157284978 157285291 314 +      
ENSG00000243176 E017 0.1779838 0.034018058 0.23247510   3 157285292 157286271 980 + 0.163 0.000 -13.596
ENSG00000243176 E018 0.3751086 0.027442404 0.48699123   3 157286272 157286341 70 + 0.000 0.164 12.474
ENSG00000243176 E019 0.3751086 0.027442404 0.48699123   3 157315811 157315895 85 + 0.000 0.164 12.474
ENSG00000243176 E020 0.3032425 0.029999636 0.48337337   3 157315896 157316145 250 + 0.000 0.163 12.469
ENSG00000243176 E021 0.1723744 0.040686229 1.00000000   3 157316146 157317885 1740 + 0.000 0.090 11.606
ENSG00000243176 E022 0.1308682 0.033420205 1.00000000   3 157381114 157381265 152 + 0.000 0.089 11.607