ENSG00000240694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000522362 ENSG00000240694 HEK293_OSMI2_6hA HEK293_TMG_6hB PNMA2 protein_coding protein_coding 5.349827 2.437289 5.409351 0.1437986 0.2958054 1.146935 5.0994382 2.41747 5.0564482 0.1245799 0.19875093 1.061521 0.95903333 0.9927 0.93650000 -0.05620000 0.184498229 0.007835696 FALSE  
ENST00000523244 ENSG00000240694 HEK293_OSMI2_6hA HEK293_TMG_6hB PNMA2 protein_coding processed_transcript 5.349827 2.437289 5.409351 0.1437986 0.2958054 1.146935 0.0957376 0.00000 0.3297012 0.0000000 0.09715071 5.086194 0.01398333 0.0000 0.05946667 0.05946667 0.007835696 0.007835696    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000240694 E001 63.1078767 0.022126619 0.13206708 0.33505672 8 26504701 26505390 690 - 1.744 1.861 0.397
ENSG00000240694 E002 157.9809775 0.001499566 0.12678087 0.32666702 8 26505391 26506872 1482 - 2.167 2.219 0.176
ENSG00000240694 E003 199.2145536 0.006612221 0.90237284 0.95306026 8 26506873 26508812 1940 - 2.275 2.299 0.077
ENSG00000240694 E004 20.5410114 0.001798862 0.03399436 0.13885911 8 26508813 26508858 46 - 1.369 1.207 -0.567
ENSG00000240694 E005 12.8006553 0.002444024 0.00413015 0.02989289 8 26508859 26508864 6 - 1.209 0.921 -1.047
ENSG00000240694 E006 14.2378698 0.003077523 0.01444898 0.07606228 8 26508865 26508888 24 - 1.234 1.003 -0.831
ENSG00000240694 E007 18.8126609 0.001741739 0.21446963 0.44689966 8 26508889 26508960 72 - 1.312 1.219 -0.327
ENSG00000240694 E008 15.7209618 0.002429773 0.30297811 0.54355790 8 26508961 26509011 51 - 1.175 1.272 0.343
ENSG00000240694 E009 12.0882833 0.002601818 0.21054652 0.44248198 8 26509012 26509018 7 - 1.055 1.183 0.460
ENSG00000240694 E010 33.0882155 0.001389951 0.69585375 0.83283627 8 26509019 26509171 153 - 1.522 1.507 -0.054
ENSG00000240694 E011 22.6856251 0.002164858 0.93541589 0.96987077 8 26509172 26509243 72 - 1.360 1.362 0.007
ENSG00000240694 E012 0.3040503 0.024441170 0.40360320   8 26509244 26509547 304 - 0.171 0.000 -10.157
ENSG00000240694 E013 22.5073646 0.001669434 0.08434247 0.25343331 8 26509548 26509600 53 - 1.395 1.272 -0.429
ENSG00000240694 E014 19.0471601 0.001767411 0.46798225 0.67872674 8 26509601 26509672 72 - 1.302 1.252 -0.176
ENSG00000240694 E015 11.6113789 0.002592457 0.83575426 0.91702232 8 26509673 26509677 5 - 1.073 1.103 0.106
ENSG00000240694 E016 0.6544085 0.018994230 0.63713927   8 26511649 26511770 122 - 0.236 0.156 -0.742
ENSG00000240694 E017 1.1176617 0.015378759 0.19969247   8 26512828 26512934 107 - 0.388 0.156 -1.742
ENSG00000240694 E018 0.7860845 0.016930637 0.06873621   8 26512935 26513015 81 - 0.343 0.000 -11.468
ENSG00000240694 E019 11.9132164 0.002631255 0.97348330 0.98866523 8 26513816 26514092 277 - 1.091 1.103 0.043