ENSG00000240344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000364629 ENSG00000240344 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIL3 protein_coding snRNA 25.25976 11.34961 37.17649 1.66389 3.367322 1.710866 2.014146 3.5223745 2.151033 2.3407811 2.1510328 -0.7089173 0.09110417 0.26393333 0.05010000 -0.213833333 0.54651879 0.02566065   FALSE
ENST00000392283 ENSG00000240344 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIL3 protein_coding protein_coding 25.25976 11.34961 37.17649 1.66389 3.367322 1.710866 5.146468 1.5679936 6.746970 0.4417336 0.5472336 2.0982852 0.21177917 0.14476667 0.18710000 0.042333333 0.83398712 0.02566065 FALSE TRUE
ENST00000465823 ENSG00000240344 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIL3 protein_coding processed_transcript 25.25976 11.34961 37.17649 1.66389 3.367322 1.710866 1.860684 0.8786756 3.063806 0.2594009 0.6415623 1.7902973 0.07296250 0.08893333 0.08106667 -0.007866667 0.99187727 0.02566065   FALSE
MSTRG.19744.5 ENSG00000240344 HEK293_OSMI2_6hA HEK293_TMG_6hB PPIL3 protein_coding   25.25976 11.34961 37.17649 1.66389 3.367322 1.710866 10.851684 2.4797788 19.607621 0.4571882 1.6851490 2.9780606 0.38735833 0.23106667 0.52850000 0.297433333 0.02566065 0.02566065 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000240344 E001 0.1614157 0.0330491479 1.000000000   2 200870907 200870955 49 - 0.066 0.001 -6.537
ENSG00000240344 E002 24.8882904 0.0250318425 0.047382119 0.17345999 2 200870956 200871151 196 - 1.273 1.480 0.717
ENSG00000240344 E003 36.6670355 0.0085578713 0.028302286 0.12217227 2 200871152 200871212 61 - 1.446 1.614 0.575
ENSG00000240344 E004 38.7469888 0.0010230990 0.118908437 0.31406428 2 200871213 200871229 17 - 1.487 1.592 0.362
ENSG00000240344 E005 52.1645262 0.0008368263 0.543932774 0.73187624 2 200871230 200871266 37 - 1.630 1.670 0.136
ENSG00000240344 E006 103.6254606 0.0005392752 0.286211380 0.52687995 2 200871267 200871373 107 - 1.923 1.972 0.164
ENSG00000240344 E007 149.7837468 0.0003418342 0.708520926 0.84084438 2 200871374 200871521 148 - 2.095 2.087 -0.025
ENSG00000240344 E008 77.1937805 0.0004890864 0.236483547 0.47251526 2 200876919 200876941 23 - 1.818 1.765 -0.179
ENSG00000240344 E009 77.0635804 0.0005419980 0.618086192 0.78249940 2 200876942 200876963 22 - 1.811 1.792 -0.064
ENSG00000240344 E010 106.8542522 0.0003843093 0.506208410 0.70510459 2 200876964 200877037 74 - 1.951 1.929 -0.075
ENSG00000240344 E011 2.4142643 0.0836876800 0.016062296 0.08203751 2 200877497 200877604 108 - 0.331 0.786 2.162
ENSG00000240344 E012 61.1868066 0.0008180445 0.011520310 0.06447448 2 200881421 200881421 1 - 1.734 1.592 -0.482
ENSG00000240344 E013 112.5424617 0.0004827282 0.030653717 0.12930540 2 200881422 200881488 67 - 1.983 1.898 -0.285
ENSG00000240344 E014 5.8803680 0.0052209026 0.170094664 0.39058340 2 200881489 200881714 226 - 0.707 0.903 0.772
ENSG00000240344 E015 3.1590302 0.0729509260 0.207146549 0.43838388 2 200881715 200881821 107 - 0.494 0.736 1.068
ENSG00000240344 E016 78.6801010 0.0005017563 0.040049363 0.15484957 2 200882342 200882382 41 - 1.832 1.735 -0.328
ENSG00000240344 E017 73.5199297 0.0005367964 0.122430016 0.31964199 2 200882383 200882435 53 - 1.799 1.725 -0.249
ENSG00000240344 E018 4.8904811 0.0687571856 0.005148040 0.03539640 2 200884902 200885261 360 - 0.539 1.025 1.961
ENSG00000240344 E019 11.4311688 0.0125605588 0.131071587 0.33351768 2 200885262 200885296 35 - 0.971 1.155 0.667
ENSG00000240344 E020 10.0080358 0.0031631283 0.083741684 0.25225741 2 200885297 200885318 22 - 0.914 1.116 0.743
ENSG00000240344 E021 11.0778236 0.0031814739 0.002172513 0.01822119 2 200885319 200885343 25 - 0.914 1.243 1.194
ENSG00000240344 E022 8.0963995 0.0215131586 0.001208419 0.01149548 2 200885344 200885367 24 - 0.759 1.189 1.607
ENSG00000240344 E023 0.9694175 0.0215133506 0.473267009   2 200885368 200885697 330 - 0.219 0.356 0.958
ENSG00000240344 E024 106.7310870 0.0004073461 0.463342693 0.67537355 2 200885698 200885772 75 - 1.950 1.925 -0.083
ENSG00000240344 E025 0.1614157 0.0330491479 1.000000000   2 200886914 200886982 69 - 0.066 0.000 -8.407
ENSG00000240344 E026 93.3661617 0.0005530657 0.590347112 0.76395431 2 200887613 200887683 71 - 1.892 1.873 -0.063
ENSG00000240344 E027 50.4532795 0.0010613694 0.232495207 0.46805801 2 200887684 200887685 2 - 1.639 1.571 -0.234
ENSG00000240344 E028 3.9637081 0.0066407333 0.193256482 0.42115023 2 200887686 200887687 2 - 0.578 0.784 0.869
ENSG00000240344 E029 5.5014899 0.0238620385 0.004988784 0.03456449 2 200888294 200888579 286 - 0.630 1.044 1.623
ENSG00000240344 E030 4.8378670 0.0054758334 0.927888967 0.96600484 2 200888949 200888955 7 - 0.693 0.682 -0.045
ENSG00000240344 E031 56.6134385 0.0018146545 0.537721449 0.72746694 2 200888956 200889243 288 - 1.663 1.704 0.136
ENSG00000240344 E032 14.0451619 0.0023646842 0.042496740 0.16122881 2 200889244 200889303 60 - 1.139 0.902 -0.870