ENSG00000239523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000463408 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.5118041 0.78059713 0.00000000 0.24116692 0.00000000 -6.3048708 0.10297917 0.14180000 0.00000000 -0.14180000 0.0004617024 0.0004617024   FALSE
ENST00000470449 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.6750773 1.60426143 0.20009936 0.23068711 0.20009936 -2.9417306 0.14075417 0.30046667 0.08180000 -0.21866667 0.2910321430 0.0004617024   FALSE
ENST00000662316 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.2806229 0.17676047 0.58035018 0.09118696 0.17739805 1.6603818 0.07186250 0.02990000 0.24366667 0.21376667 0.0948679557 0.0004617024   FALSE
ENST00000664237 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.2454956 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05062083 0.00000000 0.00000000 0.00000000   0.0004617024   FALSE
ENST00000664745 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.3227429 0.26495897 0.22545524 0.06540395 0.07657952 -0.2237635 0.07095000 0.05220000 0.09146667 0.03926667 0.7189208627 0.0004617024   FALSE
ENST00000685086 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.2536784 0.40939118 0.10308955 0.24604009 0.10308955 -1.8908309 0.05185417 0.07846667 0.05163333 -0.02683333 0.7524730217 0.0004617024   FALSE
ENST00000686121 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.2996791 0.06595658 0.09195589 0.03516719 0.09195589 0.4246983 0.06174583 0.01436667 0.03160000 0.01723333 1.0000000000 0.0004617024   FALSE
ENST00000691647 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.4317218 0.53190272 0.26345582 0.26653075 0.26345582 -0.9867261 0.08802500 0.10120000 0.09053333 -0.01066667 0.8435766517 0.0004617024   FALSE
ENST00000692354 ENSG00000239523 HEK293_OSMI2_6hA HEK293_TMG_6hB MYLK-AS1 lncRNA lncRNA 4.725372 5.360798 2.451032 0.691237 0.2639315 -1.125873 0.9301395 0.84665182 0.74815224 0.26524546 0.14184439 -0.1762214 0.19965000 0.16343333 0.31300000 0.14956667 0.5865350704 0.0004617024   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000239523 E001 0.5421338 0.036391282 0.183182071   3 123585300 123585313 14 + 0.299 0.083 -2.227
ENSG00000239523 E002 4.3635671 0.006024914 0.001444507 0.01322215 3 123585314 123585470 157 + 0.949 0.521 -1.767
ENSG00000239523 E003 2.9622654 0.037707098 0.005416687 0.03677894 3 123585471 123585478 8 + 0.839 0.394 -1.998
ENSG00000239523 E004 3.7910735 0.007763175 0.003791665 0.02797549 3 123585479 123585512 34 + 0.898 0.493 -1.712
ENSG00000239523 E005 2.4639527 0.037035490 0.420979632 0.64445500 3 123585513 123585525 13 + 0.597 0.464 -0.625
ENSG00000239523 E006 2.4993019 0.017183505 0.388110290 0.61902308 3 123585526 123585529 4 + 0.598 0.463 -0.636
ENSG00000239523 E007 2.1842929 0.011112228 0.485332738 0.69074154 3 123585530 123585530 1 + 0.540 0.430 -0.546
ENSG00000239523 E008 2.1842929 0.011112228 0.485332738 0.69074154 3 123585531 123585535 5 + 0.540 0.430 -0.546
ENSG00000239523 E009 2.1842929 0.011112228 0.485332738 0.69074154 3 123585536 123585538 3 + 0.540 0.430 -0.546
ENSG00000239523 E010 2.1842929 0.011112228 0.485332738 0.69074154 3 123585539 123585541 3 + 0.540 0.430 -0.546
ENSG00000239523 E011 2.1842929 0.011112228 0.485332738 0.69074154 3 123585542 123585543 2 + 0.540 0.430 -0.546
ENSG00000239523 E012 2.5071243 0.013995908 0.166145163 0.38537027 3 123585544 123585545 2 + 0.649 0.430 -1.031
ENSG00000239523 E013 3.3774386 0.089743421 0.219187593 0.45242758 3 123585546 123585553 8 + 0.736 0.528 -0.905
ENSG00000239523 E014 0.5008152 0.113964509 0.016484076   3 123585554 123585555 2 + 0.396 0.000 -12.680
ENSG00000239523 E015 0.7625515 0.299522323 0.213780781   3 123585556 123585563 8 + 0.398 0.148 -1.880
ENSG00000239523 E016 8.8697240 0.003482938 0.079676901 0.24417082 3 123585564 123585641 78 + 0.774 1.004 0.879
ENSG00000239523 E017 10.6320326 0.004069618 0.198962597 0.42842285 3 123585642 123585646 5 + 0.898 1.056 0.586
ENSG00000239523 E018 26.6865702 0.001789924 0.217957558 0.45100226 3 123585647 123585794 148 + 1.327 1.424 0.338
ENSG00000239523 E019 10.1962133 0.042123240 0.369900094 0.60389310 3 123585795 123585801 7 + 0.923 1.047 0.458
ENSG00000239523 E020 5.2998644 0.077688975 0.001084789 0.01056380 3 123585802 123588596 2795 + 1.055 0.548 -2.031
ENSG00000239523 E021 6.2372613 0.005971943 0.105410784 0.29134798 3 123611235 123611355 121 + 0.949 0.752 -0.764
ENSG00000239523 E022 2.1346611 0.045788515 0.099900646 0.28156138 3 123612239 123612593 355 + 0.648 0.356 -1.441
ENSG00000239523 E023 3.1893517 0.008344832 0.342426665 0.58016526 3 123629491 123629493 3 + 0.473 0.641 0.773
ENSG00000239523 E024 29.1326891 0.047515872 0.013065069 0.07071260 3 123629494 123629681 188 + 1.229 1.506 0.963
ENSG00000239523 E025 2.3449008 0.012107009 0.958084931 0.98095933 3 123629682 123629822 141 + 0.474 0.493 0.096
ENSG00000239523 E026 18.9210931 0.050472560 0.101737993 0.28490899 3 123630496 123630569 74 + 1.086 1.315 0.811
ENSG00000239523 E027 17.0979551 0.004857368 0.056641905 0.19518482 3 123630570 123630830 261 + 1.074 1.267 0.689
ENSG00000239523 E028 0.1426347 0.032649190 0.192213925   3 123644504 123644568 65 + 0.174 0.000 -11.486