ENSG00000237943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000445427 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA lncRNA 6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 1.1375658 1.7953619 0.0000000 0.4128291 0.0000000 -7.4961443 0.17921250 0.25853333 0.00000000 -0.25853333 4.958039e-13 4.958039e-13 TRUE FALSE
ENST00000449648 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA lncRNA 6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 0.5492437 0.5109331 0.4399180 0.1967272 0.1133678 -0.2114360 0.08099583 0.07020000 0.05863333 -0.01156667 9.566098e-01 4.958039e-13   FALSE
ENST00000455810 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA lncRNA 6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 3.1512922 3.7876588 3.3179957 0.4736262 0.1515078 -0.1904567 0.46616250 0.55640000 0.44356667 -0.11283333 5.125262e-01 4.958039e-13   FALSE
ENST00000663449 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA lncRNA 6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 0.5157435 0.0000000 1.5357153 0.0000000 0.7836698 7.2721308 0.07039167 0.00000000 0.20726667 0.20726667 3.172613e-01 4.958039e-13   FALSE
ENST00000667809 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA lncRNA 6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 0.3390237 0.0000000 0.9359298 0.0000000 0.9359298 6.5636612 0.04499167 0.00000000 0.12256667 0.12256667 8.989095e-01 4.958039e-13   FALSE
MSTRG.3504.2 ENSG00000237943 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKCQ-AS1 lncRNA   6.731269 6.84388 7.480473 0.7615542 0.08308295 0.128136 0.2104050 0.3231052 0.0000000 0.1617580 0.0000000 -5.0579062 0.03518750 0.05243333 0.00000000 -0.05243333 2.659093e-01 4.958039e-13 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000237943 E001 2.0239070 0.0106749208 2.982706e-04 0.0037124898 10 6580419 6580424 6 + 0.000 0.657 12.377
ENSG00000237943 E002 11.2169735 0.0089067540 2.177561e-05 0.0004106150 10 6580425 6580499 75 + 0.748 1.237 1.822
ENSG00000237943 E003 10.4252501 0.0036734394 4.247482e-05 0.0007242171 10 6580500 6580505 6 + 0.748 1.205 1.711
ENSG00000237943 E004 17.9715818 0.0122025098 8.074266e-03 0.0496630252 10 6580506 6580555 50 + 1.115 1.369 0.896
ENSG00000237943 E005 14.2963220 0.0082174684 1.831502e-02 0.0900762160 10 6580556 6580561 6 + 1.038 1.271 0.834
ENSG00000237943 E006 92.7337530 0.0004769094 7.680263e-02 0.2383867208 10 6580562 6580927 366 + 1.935 1.998 0.211
ENSG00000237943 E007 6.2626067 0.0438820733 4.916343e-01 0.6950859207 10 6581669 6582137 469 + 0.908 0.802 -0.407
ENSG00000237943 E008 15.8943942 0.0473332129 8.710015e-01 0.9364991901 10 6582138 6582201 64 + 1.218 1.226 0.031
ENSG00000237943 E009 1.6726071 0.0469725434 5.162793e-03 0.0354676785 10 6583622 6583622 1 + 0.623 0.112 -3.436
ENSG00000237943 E010 3.4830317 0.0074783657 5.030141e-03 0.0347956655 10 6583623 6583675 53 + 0.823 0.394 -1.936
ENSG00000237943 E011 78.0241150 0.0009695693 8.358719e-01 0.9171030998 10 6583676 6583804 129 + 1.890 1.899 0.030
ENSG00000237943 E012 30.0110372 0.0014151700 5.437541e-01 0.7317460084 10 6583805 6583810 6 + 1.515 1.479 -0.124
ENSG00000237943 E013 35.1178702 0.0012990001 6.268599e-01 0.7884247436 10 6583811 6583830 20 + 1.576 1.550 -0.091
ENSG00000237943 E014 47.2109714 0.0010189988 7.075834e-01 0.8402954718 10 6583831 6583860 30 + 1.671 1.691 0.067
ENSG00000237943 E015 55.4274950 0.0007887699 9.069099e-01 0.9555420873 10 6583861 6583914 54 + 1.751 1.747 -0.015
ENSG00000237943 E016 35.2029669 0.0010969986 4.926077e-01 0.6957335723 10 6583915 6583918 4 + 1.580 1.543 -0.129
ENSG00000237943 E017 61.2496829 0.0009033492 7.655585e-02 0.2378664890 10 6583919 6584117 199 + 1.835 1.760 -0.254
ENSG00000237943 E018 45.4356595 0.0063226914 7.348335e-01 0.8571619391 10 6584118 6584195 78 + 1.680 1.662 -0.061
ENSG00000237943 E019 39.9262538 0.0018004434 2.151864e-04 0.0028436391 10 6584196 6585303 1108 + 1.715 1.512 -0.691
ENSG00000237943 E020 3.4019153 0.0111020284 2.998849e-01 0.5403130410 10 6585558 6585712 155 + 0.719 0.563 -0.676
ENSG00000237943 E021 0.6129023 0.0191202390 2.347991e-01   10 6585798 6585846 49 + 0.314 0.112 -1.847
ENSG00000237943 E022 3.0729835 0.0080854984 2.856008e-01 0.5262073554 10 6586224 6586762 539 + 0.689 0.526 -0.720
ENSG00000237943 E023 1.3461915 0.0241974303 3.468731e-01   10 6586763 6586880 118 + 0.442 0.275 -0.999
ENSG00000237943 E024 0.4952057 0.2249542106 5.392425e-01   10 6586881 6586920 40 + 0.232 0.113 -1.255
ENSG00000237943 E025 1.7309736 0.0113798658 5.551864e-01 0.7399187950 10 6588266 6588396 131 + 0.382 0.486 0.545
ENSG00000237943 E026 1.6007256 0.0121989077 7.721087e-01 0.8798586314 10 6590950 6591134 185 + 0.442 0.393 -0.261
ENSG00000237943 E027 0.0000000       10 6591135 6591179 45 +      
ENSG00000237943 E028 0.3453689 0.0290009534 8.973390e-01   10 6596846 6596894 49 + 0.131 0.112 -0.255
ENSG00000237943 E029 0.3393995 0.0274424043 1.565915e-01   10 6607287 6607320 34 + 0.232 0.000 -13.415
ENSG00000237943 E030 0.4702677 0.0217681645 4.648533e-01   10 6607321 6607415 95 + 0.232 0.112 -1.263
ENSG00000237943 E031 0.7201176 0.0529500843 2.463918e-01   10 6608348 6608375 28 + 0.315 0.113 -1.845
ENSG00000237943 E032 0.8509857 0.0217602523 5.180943e-01   10 6608376 6608408 33 + 0.314 0.201 -0.847
ENSG00000237943 E033 0.5173834 0.0535871829 6.354799e-02   10 6613631 6613689 59 + 0.315 0.000 -13.843
ENSG00000237943 E034 0.3393995 0.0274424043 1.565915e-01   10 6613690 6613903 214 + 0.232 0.000 -13.415
ENSG00000237943 E035 0.1779838 0.0347135539 4.138969e-01   10 6613934 6613987 54 + 0.131 0.000 -12.440
ENSG00000237943 E036 0.2027342 0.0362549100 5.684425e-01   10 6615370 6615518 149 + 0.000 0.112 11.378
ENSG00000237943 E037 0.3453689 0.0290009534 8.973390e-01   10 6615519 6615637 119 + 0.131 0.112 -0.255
ENSG00000237943 E038 0.8405746 0.0196678197 5.247241e-01   10 6615763 6615924 162 + 0.314 0.202 -0.841
ENSG00000237943 E039 0.0000000       10 6615925 6615959 35 +      
ENSG00000237943 E040 0.0000000       10 6616006 6616921 916 +