ENSG00000237854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000690974 ENSG00000237854 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 11.24585 11.29611 9.751003 1.808434 0.3367156 -0.2120013 1.3011494 1.5397230 0.775392 0.5411048 0.1332366 -0.9805256 0.11837083 0.12580000 0.07926667 -0.04653333 0.745553883 0.003326631   FALSE
ENST00000692407 ENSG00000237854 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene processed_transcript 11.24585 11.29611 9.751003 1.808434 0.3367156 -0.2120013 4.4613924 3.5888323 5.393853 0.6425500 0.4531251 0.5864596 0.39680833 0.31753333 0.55190000 0.23436667 0.003326631 0.003326631   FALSE
MSTRG.14980.1 ENSG00000237854 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   11.24585 11.29611 9.751003 1.808434 0.3367156 -0.2120013 3.5248268 4.3250942 2.585830 0.5137989 0.1989983 -0.7398675 0.31407083 0.38936667 0.26723333 -0.12213333 0.248800988 0.003326631   FALSE
MSTRG.14980.3 ENSG00000237854 HEK293_OSMI2_6hA HEK293_TMG_6hB   transcribed_unprocessed_pseudogene   11.24585 11.29611 9.751003 1.808434 0.3367156 -0.2120013 0.8844915 0.6135607 0.468488 0.1241029 0.1429200 -0.3820472 0.07570417 0.05416667 0.04826667 -0.00590000 0.958373116 0.003326631   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000237854 E001 17.128949 0.060377023 2.226199e-02 1.034756e-01 17 68101565 68101666 102 + 1.041 1.331 1.032
ENSG00000237854 E002 14.431368 0.062408554 5.979724e-02 2.023261e-01 17 68101667 68101671 5 + 1.008 1.255 0.885
ENSG00000237854 E003 39.509588 0.001970717 9.022696e-08 3.384717e-06 17 68101672 68101873 202 + 1.370 1.686 1.082
ENSG00000237854 E004 15.699082 0.002468275 3.353428e-03 2.549875e-02 17 68101874 68101877 4 + 1.032 1.287 0.915
ENSG00000237854 E005 21.557103 0.001755861 5.436022e-03 3.689311e-02 17 68101878 68101907 30 + 1.200 1.403 0.710
ENSG00000237854 E006 28.787786 0.019052268 6.893013e-01 8.286310e-01 17 68101908 68101959 52 + 1.437 1.468 0.108
ENSG00000237854 E007 1.171964 0.014804716 7.828601e-01   17 68101960 68101961 2 + 0.356 0.297 -0.372
ENSG00000237854 E008 36.179383 0.025774365 4.940399e-01 6.967193e-01 17 68102943 68103058 116 + 1.593 1.526 -0.230
ENSG00000237854 E009 2.756166 0.156377390 9.997374e-01 1.000000e+00 17 68106422 68106553 132 + 0.552 0.548 -0.016
ENSG00000237854 E010 57.081257 0.006910708 3.559817e-01 5.924993e-01 17 68114422 68114525 104 + 1.784 1.719 -0.222
ENSG00000237854 E011 0.000000       17 68114526 68114527 2 +      
ENSG00000237854 E012 2.968717 0.008595870 6.921537e-01 8.304153e-01 17 68115061 68115178 118 + 0.643 0.568 -0.331
ENSG00000237854 E013 3.090031 0.008386311 8.201047e-01 9.081300e-01 17 68115179 68115518 340 + 0.599 0.621 0.100
ENSG00000237854 E014 55.345686 0.002745887 3.647325e-03 2.718215e-02 17 68125390 68125480 91 + 1.830 1.667 -0.552
ENSG00000237854 E015 4.010238 0.006984330 8.042949e-01 8.987989e-01 17 68125558 68125584 27 + 0.720 0.670 -0.207
ENSG00000237854 E016 208.229542 0.004282433 1.534732e-03 1.384651e-02 17 68125585 68126573 989 + 2.369 2.263 -0.354
ENSG00000237854 E017 10.142479 0.003660969 7.119893e-02 2.271461e-01 17 68160990 68161227 238 + 0.914 1.097 0.674