ENSG00000236333

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435350 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.077369240 0.206570903 0.00000000 0.021352906 0.00000000 -4.4367675 0.17190000 0.521333333 0.00000000 -0.52133333 8.361257e-05 8.361257e-05 TRUE FALSE
ENST00000549957 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA retained_intron 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.028998028 0.009285214 0.08887107 0.005262448 0.02324361 2.3580533 0.06428750 0.023733333 0.19706667 0.17333333 3.323314e-01 8.361257e-05 FALSE FALSE
ENST00000655489 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.079334352 0.073058421 0.08444837 0.021918000 0.02840474 0.1853995 0.17496667 0.186800000 0.15946667 -0.02733333 9.884979e-01 8.361257e-05   FALSE
ENST00000662127 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.093379142 0.039213175 0.14860196 0.039213175 0.08184493 1.6882941 0.18210417 0.097966667 0.25976667 0.16180000 7.188806e-01 8.361257e-05 TRUE FALSE
ENST00000663532 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.025876830 0.000000000 0.02191855 0.000000000 0.02191855 1.6743951 0.06901667 0.000000000 0.03503333 0.03503333 8.469509e-01 8.361257e-05 TRUE FALSE
ENST00000665830 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.017243075 0.002962342 0.04308527 0.002962342 0.01094005 2.0339852 0.03800417 0.006966667 0.09503333 0.08806667 3.632405e-01 8.361257e-05 FALSE FALSE
ENST00000667144 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.024594842 0.048447319 0.00000000 0.048447319 0.00000000 -2.5471368 0.05751250 0.113766667 0.00000000 -0.11376667 8.116678e-01 8.361257e-05   FALSE
ENST00000667465 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.007232935 0.002932876 0.03251785 0.002932876 0.02231350 1.7170254 0.01679583 0.006900000 0.07923333 0.07233333 9.057925e-01 8.361257e-05 TRUE FALSE
ENST00000668786 ENSG00000236333 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 0.4568699 0.4002674 0.5029554 0.01475718 0.06961079 0.3222689 0.035473771 0.017797180 0.08351238 0.014277579 0.01666302 1.7502189 0.07380833 0.042566667 0.17440000 0.13183333 5.722436e-01 8.361257e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000236333 E001 1.1883600 0.148583398 0.102211591   12 72249964 72253507 3544 - 0.464 0.125 -2.525
ENSG00000236333 E002 0.0000000       12 72253508 72253512 5 -      
ENSG00000236333 E003 0.0000000       12 72253513 72253530 18 -      
ENSG00000236333 E004 0.0000000       12 72253531 72253532 2 -      
ENSG00000236333 E005 0.0000000       12 72253533 72253535 3 -      
ENSG00000236333 E006 0.1426347 0.031805422 0.541164731   12 72253536 72253537 2 - 0.119 0.000 -11.637
ENSG00000236333 E007 0.1426347 0.031805422 0.541164731   12 72253538 72253545 8 - 0.119 0.000 -11.637
ENSG00000236333 E008 0.1426347 0.031805422 0.541164731   12 72253546 72253548 3 - 0.119 0.000 -11.637
ENSG00000236333 E009 0.3206185 0.027442404 0.232692182   12 72253549 72253550 2 - 0.212 0.000 -12.521
ENSG00000236333 E010 0.5233527 0.023568964 0.636550730   12 72253551 72253559 9 - 0.212 0.124 -0.923
ENSG00000236333 E011 0.9880109 0.015238029 0.894971490   12 72253560 72253589 30 - 0.289 0.300 0.075
ENSG00000236333 E012 5.0238070 0.005610368 0.393460336 0.62312197 12 72253590 72254082 493 - 0.733 0.821 0.355
ENSG00000236333 E013 4.4952431 0.007039073 0.215578238 0.44814836 12 72254083 72254522 440 - 0.823 0.635 -0.771
ENSG00000236333 E014 2.4037535 0.009740700 0.027716099 0.12046249 12 72254523 72254614 92 - 0.679 0.299 -1.926
ENSG00000236333 E015 4.4308849 0.025941458 0.501112476 0.70158590 12 72254615 72255403 789 - 0.782 0.667 -0.472
ENSG00000236333 E016 3.5934306 0.009621388 0.499287239 0.70032579 12 72255404 72255677 274 - 0.617 0.697 0.339
ENSG00000236333 E017 1.5079670 0.039646941 0.624216199 0.78677602 12 72255678 72255774 97 - 0.354 0.425 0.404
ENSG00000236333 E018 2.7369960 0.025054451 0.012425503 0.06814585 12 72255775 72258240 2466 - 0.734 0.299 -2.157
ENSG00000236333 E019 0.0000000       12 72259386 72259540 155 -      
ENSG00000236333 E020 2.3693844 0.030662367 0.131221785 0.33372985 12 72259577 72261197 1621 - 0.647 0.367 -1.373
ENSG00000236333 E021 1.4701153 0.019037029 0.277746988 0.51784407 12 72261198 72261428 231 - 0.504 0.299 -1.147
ENSG00000236333 E022 2.6006229 0.033488958 0.390652902 0.62089664 12 72261429 72262110 682 - 0.505 0.631 0.576
ENSG00000236333 E023 3.0713336 0.026325975 0.069750036 0.22429768 12 72262111 72264481 2371 - 0.733 0.424 -1.411
ENSG00000236333 E024 4.0341805 0.006549320 0.011823832 0.06573126 12 72264482 72264616 135 - 0.505 0.842 1.435
ENSG00000236333 E025 2.1310202 0.010381912 0.112217664 0.30281559 12 72264617 72264621 5 - 0.354 0.600 1.245
ENSG00000236333 E026 1.7986736 0.029572622 0.007278986 0.04596960 12 72269450 72271822 2373 - 0.618 0.124 -3.249
ENSG00000236333 E027 6.9933961 0.006660580 0.002305569 0.01908735 12 72271823 72272122 300 - 0.706 1.039 1.283
ENSG00000236333 E028 2.2723697 0.011419730 0.135661166 0.34081966 12 72272123 72272158 36 - 0.410 0.634 1.071
ENSG00000236333 E029 1.6650768 0.014020732 0.091422852 0.26632298 12 72272159 72272162 4 - 0.288 0.561 1.486
ENSG00000236333 E030 2.4866828 0.032346336 0.097711963 0.27777476 12 72272163 72272236 74 - 0.409 0.665 1.211
ENSG00000236333 E031 2.0715408 0.009911333 0.635456179 0.79388430 12 72272237 72272357 121 - 0.460 0.521 0.297
ENSG00000236333 E032 0.7804750 0.019387492 0.210017793   12 72272358 72272501 144 - 0.353 0.124 -1.923
ENSG00000236333 E033 0.1426347 0.031805422 0.541164731   12 72272502 72272554 53 - 0.119 0.000 -11.637
ENSG00000236333 E034 0.1426347 0.031805422 0.541164731   12 72272555 72272580 26 - 0.119 0.000 -11.637
ENSG00000236333 E035 0.1426347 0.031805422 0.541164731   12 72272581 72272661 81 - 0.119 0.000 -11.637
ENSG00000236333 E036 0.3150090 0.026212375 0.934549210   12 72272765 72272921 157 - 0.119 0.124 0.077
ENSG00000236333 E037 0.0000000       12 72272922 72272954 33 -      
ENSG00000236333 E038 0.0000000       12 72272955 72272956 2 -      
ENSG00000236333 E039 0.0000000       12 72272957 72273093 137 -      
ENSG00000236333 E040 0.0000000       12 72273094 72273097 4 -      
ENSG00000236333 E041 0.0000000       12 72273098 72273482 385 -      
ENSG00000236333 E042 0.0000000       12 72273483 72273501 19 -      
ENSG00000236333 E043 0.0000000       12 72273502 72273507 6 -      
ENSG00000236333 E044 0.0000000       12 72273508 72273844 337 -      
ENSG00000236333 E045 0.0000000       12 72273845 72273884 40 -      
ENSG00000236333 E046 0.0000000       12 72273885 72273945 61 -      
ENSG00000236333 E047 0.0000000       12 72274820 72274907 88 -      
ENSG00000236333 E048 0.1779838 0.034964787 0.539193739   12 72276821 72276954 134 - 0.119 0.000 -11.640