ENSG00000236144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000444728 ENSG00000236144 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM147-AS1 lncRNA lncRNA 20.16342 26.44121 14.11984 1.442024 1.883837 -0.9045884 1.157182 1.890297 0.1467975 0.6636460 0.1467975 -3.5992499 0.05572083 0.07086667 0.00920000 -0.06166667 0.21081472 0.03387274   FALSE
ENST00000588286 ENSG00000236144 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM147-AS1 lncRNA lncRNA 20.16342 26.44121 14.11984 1.442024 1.883837 -0.9045884 5.591700 6.862858 4.3731099 0.6961070 1.2637884 -0.6489553 0.28180417 0.25900000 0.29520000 0.03620000 0.93345679 0.03387274 FALSE FALSE
ENST00000589137 ENSG00000236144 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM147-AS1 lncRNA lncRNA 20.16342 26.44121 14.11984 1.442024 1.883837 -0.9045884 4.780006 5.438042 0.5471139 0.5309787 0.5471139 -3.2896936 0.21273750 0.20470000 0.03413333 -0.17056667 0.16852899 0.03387274   FALSE
ENST00000590717 ENSG00000236144 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM147-AS1 lncRNA lncRNA 20.16342 26.44121 14.11984 1.442024 1.883837 -0.9045884 5.145903 6.536026 5.4467655 0.1057158 0.4773510 -0.2625732 0.27465417 0.24890000 0.39166667 0.14276667 0.03387274 0.03387274   FALSE
ENST00000670097 ENSG00000236144 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM147-AS1 lncRNA lncRNA 20.16342 26.44121 14.11984 1.442024 1.883837 -0.9045884 2.135346 3.937155 1.9324679 0.3763383 0.4559437 -1.0229224 0.10411250 0.14983333 0.14343333 -0.00640000 0.96717208 0.03387274 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000236144 E001 1.689207 2.0100654248 9.174234e-01 9.609210e-01 19 35540738 35540738 1 - 0.188 0.441 1.704
ENSG00000236144 E002 53.683268 0.0029983971 4.141478e-02 1.584050e-01 19 35540739 35540859 121 - 1.593 1.707 0.387
ENSG00000236144 E003 55.592402 0.0008434873 1.212071e-01 3.177829e-01 19 35540860 35540914 55 - 1.642 1.712 0.238
ENSG00000236144 E004 35.873010 0.0013124657 2.950598e-01 5.355780e-01 19 35540915 35540916 2 - 1.465 1.522 0.195
ENSG00000236144 E005 67.152740 0.0011350582 3.204634e-01 5.600994e-01 19 35540917 35540970 54 - 1.750 1.784 0.117
ENSG00000236144 E006 117.638487 0.0020087064 7.902885e-03 4.887086e-02 19 35540971 35541137 167 - 1.934 2.036 0.344
ENSG00000236144 E007 64.378872 0.0007001083 1.124877e-03 1.085582e-02 19 35541138 35541183 46 - 1.631 1.790 0.540
ENSG00000236144 E008 57.380568 0.0007892399 3.762519e-05 6.547415e-04 19 35541184 35541202 19 - 1.520 1.748 0.774
ENSG00000236144 E009 73.461322 0.0084904287 2.376636e-03 1.954894e-02 19 35541203 35541282 80 - 1.649 1.848 0.673
ENSG00000236144 E010 64.449522 0.0170828919 3.474879e-02 1.409464e-01 19 35541283 35541314 32 - 1.613 1.788 0.592
ENSG00000236144 E011 199.127860 0.0003455944 1.148499e-02 6.432864e-02 19 35541315 35541581 267 - 2.199 2.256 0.190
ENSG00000236144 E012 71.262736 0.0050372423 1.000000e+00 1.000000e+00 19 35541582 35541584 3 - 1.812 1.800 -0.038
ENSG00000236144 E013 37.578193 0.0123597212 4.011395e-01 6.292336e-01 19 35541585 35541626 42 - 1.590 1.510 -0.273
ENSG00000236144 E014 55.418653 0.0011230133 3.425558e-01 5.802530e-01 19 35541627 35541750 124 - 1.741 1.673 -0.229
ENSG00000236144 E015 193.078827 0.0003088324 1.812958e-01 4.056660e-01 19 35541751 35541928 178 - 2.211 2.233 0.072
ENSG00000236144 E016 159.673362 0.0003691347 3.675698e-01 6.020564e-01 19 35541929 35542074 146 - 2.138 2.149 0.039
ENSG00000236144 E017 233.667260 0.0066078244 2.758935e-01 5.159802e-01 19 35542075 35542910 836 - 2.349 2.292 -0.188
ENSG00000236144 E018 193.893214 0.0002981078 9.741304e-02 2.772550e-01 19 35542911 35543097 187 - 2.279 2.214 -0.219
ENSG00000236144 E019 162.213295 0.0008623010 9.126749e-01 9.584424e-01 19 35543098 35543273 176 - 2.163 2.148 -0.048
ENSG00000236144 E020 384.657851 0.0001820095 1.293056e-01 3.306511e-01 19 35543274 35544111 838 - 2.563 2.515 -0.161
ENSG00000236144 E021 505.858049 0.0032005556 4.098026e-06 9.696796e-05 19 35544112 35545318 1207 - 2.746 2.601 -0.482
ENSG00000236144 E022 51.002122 0.0014923761 9.397679e-01 9.721083e-01 19 35545319 35545389 71 - 1.679 1.657 -0.075
ENSG00000236144 E023 48.520767 0.0076270505 5.844108e-01 7.599404e-01 19 35545390 35545563 174 - 1.616 1.644 0.094
ENSG00000236144 E024 10.683934 0.0033517753 1.725861e-03 1.520300e-02 19 35545937 35546029 93 - 0.642 1.082 1.709